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学科主题: 药物依赖
题名:
Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood
作者: Suo, Lin1; Zhao, Liyan1; Si, Jijian2; Liu, Jianfeng1; Zhu, Weili1; Chai, Baisheng3,4; Zhang, Yan1; Feng, Jiajia1; Ding, Zengbo1; Luo, Yixiao1; Shi, Haishui5; Shi, Jie1; Lu, Lin1
关键词: adolescence ; depression ; mTOR ; predictable chronic mild stress ; resilience
刊名: NEUROPSYCHOPHARMACOLOGY
发表日期: 2013-07-01
DOI: 10.1038/npp.2013.67
卷: 38, 期:8, 页:1387-1400
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: DEPRESSION-LIKE BEHAVIORS ; SIGNALING PATHWAY ; MAMMALIAN TARGET ; NEUROTROPHIC FACTOR ; PREFRONTAL CORTEX ; FEMALE RATS ; ANXIETY ; BRAIN ; ANTIDEPRESSANT ; ACTIVATION
英文摘要:

Stress in adolescence has been widely demonstrated to have a lasting impact in humans and animal models. Developmental risk and protective factors play an important role in the responses to stress in adulthood. Mild-to-moderate stress in adolescence may resist the negative impacts of adverse events in adulthood. However, little research on resilience has been conducted. In this study, we used a predictable chronic mild stress (PCMS) procedure (5 min of daily restraint stress for 28 days) in adolescent rats (postnatal days (PNDs) 28-55) to test the resilience effect of PCMS on depressive-like behavior in the sucrose preference test and forced swim test and anxiety-like behavior in the novelty-suppressed feeding test and elevated plus maze in adulthood. We also investigated the role of mammalian target of rapamycin (mTOR) signaling in the brain during the PCMS procedure in adolescence. Moreover, we investigated the effect of PCMS in adolescence on subsequent responses to chronic unpredictable stress (CUS; PNDs 63-83) in adulthood. The results demonstrated that PCMS during adolescence produced antidepressant-and anxiolytic-like effects and increased mTOR signaling activity in the prefrontal cortex in early adulthood. Either systemic administration or intra-PFC infusion of the mTOR inhibitor rapamycin completely blocked the behavioral effects produced by PCMS in adolescence. PCMS during adolescence resisted depressive-and anxiety-like behavior caused by CUS in adulthood. These findings indicate that PCMS in adolescence can contribute to resilience against depression and anxiety caused by stress in adulthood.

语种: 英语
所属项目编号: 31230033 ; 81221002 ; 91132716 ; 20121323120002
项目资助者: Natural Science Foundation of China ; Specific Foundation for Doctoral Institute Program from the State Education Ministry of China
WOS记录号: WOS:000320368200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54402
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Guiyang Med Univ, Sch Pharm, Guiyang, Peoples R China
2.Guiyang Med Univ, Affiliated Hosp, Guiyang, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
4.Tianjin Mental Hlth Ctr, Tianjin Mental Hlth Inst, Tianjin, Peoples R China
5.Hebei Med Univ, Dept Biochem & Mol Biol, Basic Med Coll, Shijiazhuang, Peoples R China

Recommended Citation:
Suo, Lin,Zhao, Liyan,Si, Jijian,et al. Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood[J]. NEUROPSYCHOPHARMACOLOGY,2013,38(8):1387-1400.
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