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Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood
Suo, Lin1; Zhao, Liyan1; Si, Jijian2; Liu, Jianfeng1; Zhu, Weili1; Chai, Baisheng3,4; Zhang, Yan1; Feng, Jiajia1; Ding, Zengbo1; Luo, Yixiao1; Shi, Haishui5; Shi, Jie1; Lu, Lin1
关键词Adolescence Depression Mtor Predictable Chronic Mild Stress Resilience
刊名NEUROPSYCHOPHARMACOLOGY
2013-07-01
DOI10.1038/npp.2013.67
38期:8页:1387-1400
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]DEPRESSION-LIKE BEHAVIORS ; SIGNALING PATHWAY ; MAMMALIAN TARGET ; NEUROTROPHIC FACTOR ; PREFRONTAL CORTEX ; FEMALE RATS ; ANXIETY ; BRAIN ; ANTIDEPRESSANT ; ACTIVATION
英文摘要

Stress in adolescence has been widely demonstrated to have a lasting impact in humans and animal models. Developmental risk and protective factors play an important role in the responses to stress in adulthood. Mild-to-moderate stress in adolescence may resist the negative impacts of adverse events in adulthood. However, little research on resilience has been conducted. In this study, we used a predictable chronic mild stress (PCMS) procedure (5 min of daily restraint stress for 28 days) in adolescent rats (postnatal days (PNDs) 28-55) to test the resilience effect of PCMS on depressive-like behavior in the sucrose preference test and forced swim test and anxiety-like behavior in the novelty-suppressed feeding test and elevated plus maze in adulthood. We also investigated the role of mammalian target of rapamycin (mTOR) signaling in the brain during the PCMS procedure in adolescence. Moreover, we investigated the effect of PCMS in adolescence on subsequent responses to chronic unpredictable stress (CUS; PNDs 63-83) in adulthood. The results demonstrated that PCMS during adolescence produced antidepressant-and anxiolytic-like effects and increased mTOR signaling activity in the prefrontal cortex in early adulthood. Either systemic administration or intra-PFC infusion of the mTOR inhibitor rapamycin completely blocked the behavioral effects produced by PCMS in adolescence. PCMS during adolescence resisted depressive-and anxiety-like behavior caused by CUS in adulthood. These findings indicate that PCMS in adolescence can contribute to resilience against depression and anxiety caused by stress in adulthood.

语种英语
WOS记录号WOS:000320368200002
项目编号31230033 ; 81221002 ; 91132716 ; 20121323120002
资助机构Natural Science Foundation of China ; Specific Foundation for Doctoral Institute Program from the State Education Ministry of China
引用统计
被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54402
专题中国药物依赖性研究所
作者单位1.Guiyang Med Univ, Sch Pharm, Guiyang, Peoples R China
2.Guiyang Med Univ, Affiliated Hosp, Guiyang, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
4.Tianjin Mental Hlth Ctr, Tianjin Mental Hlth Inst, Tianjin, Peoples R China
5.Hebei Med Univ, Dept Biochem & Mol Biol, Basic Med Coll, Shijiazhuang, Peoples R China
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GB/T 7714
Suo, Lin,Zhao, Liyan,Si, Jijian,et al. Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood[J]. NEUROPSYCHOPHARMACOLOGY,2013,38(8):1387-1400.
APA Suo, Lin.,Zhao, Liyan.,Si, Jijian.,Liu, Jianfeng.,Zhu, Weili.,...&Lu, Lin.(2013).Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood.NEUROPSYCHOPHARMACOLOGY,38(8),1387-1400.
MLA Suo, Lin,et al."Predictable Chronic Mild Stress in Adolescence Increases Resilience in Adulthood".NEUROPSYCHOPHARMACOLOGY 38.8(2013):1387-1400.
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