IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
The Effect of Cardiopulmonary Bypass Duration on Renal Injury after Congenital Heart Surgery in Infants and Young Children
Zheng, Jianyong1; Xiao, Yanyan1; Chong, Mei1; Chen, Yan1; Yao, Yong2; Jin, Mei1; Liu, Yinglong1; Han, Ling1
关键词Renal Injury Cardiopulmonary Bypass Congenital Heart Surgery Infants And Young Children
刊名ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
2013-09-01
22期:5页:693-698
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]PUMP CORONARY REVASCULARIZATION ; GELATINASE-ASSOCIATED LIPOCALIN ; ACUTE KIDNEY INJURY ; PERITONEAL-DIALYSIS ; ON-PUMP ; DISEASE ; FAILURE
英文摘要

Background. Improvements in surgical techniques and perioperative management mean that more complex cardiac procedures are being performed on very young patients.

Objectives. The aim of this study is to evaluate the effects of the duration of cardiopulmonary bypass (CPB) on renal injury after congenital heart surgery in infants and young children.

Material and Methods. 58 children with ages <= 3 years undergoing CPB surgery were divided into three groups according to the duration of their CPB: Group I was < 90 min, n = 15; Group II, 90-149 min, n = 25; and Group III was >= 150 min, n = 18. Urinary neutrophil gelatinase-associated lipocalin, interleukin-18, microalbumin and alpha 1-microglobulin were measured at baseline and 4 h, 6 h, 12 h and 24 h after surgery.

Results. No significant differences were noted among the groups in terms of gender, age, weight and baseline serum creatinine. The incidence of acute kidney injury (based on serum creatinine increase) after surgery were 13.3% (2/15) in Group I, 52.0% (13/25) in Group II and 77.8% (14/18) in Group III. 4 children developed acute renal failure (ARF) requiring peritoneal dialysis; all of them were in Group III. The levels of urinary biomarkers increased significantly, peaked at 4 h and remained elevated up to 24 h after surgery. Group III had significantly higher levels of urinary biomarkers than Groups I and II at 4-12 h after surgery, while the levels were not significantly different at 24 h.

Conclusions. Prolonged CPB duration was related to more severe renal tubular injury and acute renal failure. Measurements of urinary kidney specific biomarkers in infants and children with a CPB duration of more than 150 min might help identify those at high risk for ARF

语种英语
WOS记录号WOS:000328605800011
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54404
专题北京大学第一临床医学院
作者单位1.Capital Med Univ, Beijing Anzhen Hosp, Dept Pediat Cardiol & Cardiac Surg, Beijing 100029, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat Nephrol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Jianyong,Xiao, Yanyan,Chong, Mei,et al. The Effect of Cardiopulmonary Bypass Duration on Renal Injury after Congenital Heart Surgery in Infants and Young Children[J]. ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE,2013,22(5):693-698.
APA Zheng, Jianyong.,Xiao, Yanyan.,Chong, Mei.,Chen, Yan.,Yao, Yong.,...&Han, Ling.(2013).The Effect of Cardiopulmonary Bypass Duration on Renal Injury after Congenital Heart Surgery in Infants and Young Children.ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE,22(5),693-698.
MLA Zheng, Jianyong,et al."The Effect of Cardiopulmonary Bypass Duration on Renal Injury after Congenital Heart Surgery in Infants and Young Children".ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE 22.5(2013):693-698.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zheng, Jianyong]的文章
[Xiao, Yanyan]的文章
[Chong, Mei]的文章
百度学术
百度学术中相似的文章
[Zheng, Jianyong]的文章
[Xiao, Yanyan]的文章
[Chong, Mei]的文章
必应学术
必应学术中相似的文章
[Zheng, Jianyong]的文章
[Xiao, Yanyan]的文章
[Chong, Mei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。