IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Blockade of both CD28/B7 and OX40/OX40L co-stimulatory signal pathways prolongs the survival of islet xenografts
Wang, GM; Yang, Y; Jin, YZ; Li, AL; Hao, J; Gao, X; Xie, SS
刊名TRANSPLANTATION PROCEEDINGS
2005-12-01
DOI10.1016/j.transproceed.2005.10.117
37期:10页:4449-4451
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Surgery ; Transplantation
研究领域[WOS]Immunology ; Surgery ; Transplantation
关键词[WOS]REJECTION ; ALLOGRAFT ; OX40
英文摘要

CTLA4Ig, a recombinant fusion protein composed of the extracellular domain of human CTLA4 and the constant region of human IgG1, inhibits the interaction of CD28/B7 pathway by binding the B7 molecule. OX40Ig, a recombinant fusion protein composed of the extracellular domain of human OX40 and the constant region of human IgG1, abrogates the interaction of OX40/OX40L pathway by binding the OX40L on APCs. So blockade of CD28/B7 or OX40/OX40L co-stimulatory pathways alone in mice with CTLA4Ig or OX40Ig can result in finitely prolonging the survival of islet grafts (43.2 +/- 4.81 and 67.7 +/- 7.74 days, respectively). In this study, a novel replication-defective adenovirus containing both of the CTLA4Ig and OX40Ig genes, AdCTLA4Ig-IRES-OX40Ig, was constructed by homologous recombination and injected into the streptozocin-rendered diabetic BalB/c mouse recipients (H-2(d)) through the tail vein, at the same day, the freshly isolated islets from Lewis rats (RT-1) were transplanted under the left kidney capsule of the recipients. The results showed that the mean survival time of the islet xenografts in the AdCTLA4Ig-IRES-OX40Ig-treated diabetic mice was significantly prolonged (100.3 +/- 14.94 days), while those in the untreated or AdEGFP-treated mice were rejected in normal fashion (6.7 +/- 0.94 and 7.0 +/- 1.0 days, respectively). In conclusion, utilizing AdCTLA4Ig-IRES-OX40Ig in vivo which can simultaneously express CTLA4Ig and OX40Ig proteins can improve the survival of Lewis -> BalB/c islet xenografts.

语种英语
WOS记录号WOS:000234412900079
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54408
Collection北京大学基础医学院_免疫学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Wang, GM,Yang, Y,Jin, YZ,et al. Blockade of both CD28/B7 and OX40/OX40L co-stimulatory signal pathways prolongs the survival of islet xenografts[J]. TRANSPLANTATION PROCEEDINGS,2005,37(10):4449-4451.
APA Wang, GM.,Yang, Y.,Jin, YZ.,Li, AL.,Hao, J.,...&Xie, SS.(2005).Blockade of both CD28/B7 and OX40/OX40L co-stimulatory signal pathways prolongs the survival of islet xenografts.TRANSPLANTATION PROCEEDINGS,37(10),4449-4451.
MLA Wang, GM,et al."Blockade of both CD28/B7 and OX40/OX40L co-stimulatory signal pathways prolongs the survival of islet xenografts".TRANSPLANTATION PROCEEDINGS 37.10(2005):4449-4451.
Files in This Item: Download All
File Name/Size DocType Version Access License
1-s2.0-S004113450501(61KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Wang, GM]'s Articles
[Yang, Y]'s Articles
[Jin, YZ]'s Articles
百度学术
百度学术Similar articles in
[Wang, GM]'s Articles
[Yang, Y]'s Articles
[Jin, YZ]'s Articles
必应学术
必应学术Similar articles in
[Wang, GM]'s Articles
[Yang, Y]'s Articles
[Jin, YZ]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 1-s2.0-S0041134505012510-main.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.