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学科主题临床医学
Pure alpha-fetoprotein-producing neuroendocrine carcinoma of the pancreas: a case report
Zhu, Xiang1,2; Yong, Huijuan3; Zhang, Li3; Huang, Yonghui3; Zheng, Jie1,2; Liu, Cuiling1,2; Xiu, Dianrong4; Zhang, Pan3
关键词Alpha-fetoprotein Neuroendocrine Carcinoma Pancreas
刊名BMC GASTROENTEROLOGY
2015-02-12
DOI10.1186/s12876-015-0246-x
15
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]CHORIONIC GONADOTROPIN-BETA ; ISLET-CELL TUMORS ; HEPATOID CARCINOMA ; ENDOCRINE TUMORS ; EPIDEMIOLOGY ; NEOPLASMS ; MARKERS
英文摘要

Background: Alpha-fetoprotein (AFP)-producing pancreatic neuroendocrine tumors (pNETs) are rare, and the few reported cases usually coexisted with other malignant components such as adenocarcinoma or hepatoid carcinoma. We present here the first case of pure AFP-producing pNET.

Case presentation: A 56-year-old male patient underwent resection of the pancreatic tail and body because of elevated serum AFP levels and pancreatic mass. Microscopy showed that the tumor tissue consisted of large and small solid nests of polygonal cells. The tumor cells were positive for chromogranin A, synaptophysin, CD99, cytokeratin 19, pan-cytokeratin and beta-catenin, and also showed diffuse immunoreactivity for AFP and human chorionic gonadotrophin. The mitotic rate was nearly 30 per 10 high-power fields and the Ki-67 index was nearly 25%. The histopathologic findings supported the diagnosis of an AFP-producing pNET. Other malignant components were not found. Serum AFP levels decreased to near-normal after operation and gradually increased to > 1000 ng/ml at 5 months post-surgery. Recurrence and hepatic metastases were revealed by computed tomography. The patient died 21 months after surgery.

Conclusion: This was the first case of pure AFP-producing pNET to be reported in the English literature. Serum AFP levels may provide useful information for monitoring the therapeutic effectiveness, early recurrence or metastases.

语种英语
WOS记录号WOS:000349856600002
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54419
Collection北京大学第三临床医学院_病理科
作者单位1.Peking Univ, Dept Surg, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Pathol, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100191, Peoples R China
4.Peking Univ, Dept Gastroenterol, Hosp 3, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Xiang,Yong, Huijuan,Zhang, Li,et al. Pure alpha-fetoprotein-producing neuroendocrine carcinoma of the pancreas: a case report[J]. BMC GASTROENTEROLOGY,2015,15.
APA Zhu, Xiang.,Yong, Huijuan.,Zhang, Li.,Huang, Yonghui.,Zheng, Jie.,...&Zhang, Pan.(2015).Pure alpha-fetoprotein-producing neuroendocrine carcinoma of the pancreas: a case report.BMC GASTROENTEROLOGY,15.
MLA Zhu, Xiang,et al."Pure alpha-fetoprotein-producing neuroendocrine carcinoma of the pancreas: a case report".BMC GASTROENTEROLOGY 15(2015).
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