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学科主题基础医学
Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance
Huang, Jie2,3; Wang, Haibin1,4; Chen, Yingyu3; Wang, Xiaochen1; Zhang, Hong1,2
关键词Residual body PS Engulfment Phagosome Autophagy C. elegans
刊名DEVELOPMENT
2012-12-15
DOI10.1242/dev.086769
139期:24页:4613-4622
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Developmental Biology
资助者National Basic Research Program of China ; Howard Hughes Medical Institute ; National Basic Research Program of China ; Howard Hughes Medical Institute
研究领域[WOS]Developmental Biology
关键词[WOS]NEMATODE CAENORHABDITIS-ELEGANS ; APOPTOTIC CELLS ; SERTOLI-CELLS ; CRKII/DOCK180/RAC PATHWAY ; PHAGOSOME MATURATION ; ENGULFMENT ; SPERM ; MIGRATION ; RECEPTOR ; PHAGOCYTOSIS
英文摘要

Generation of spermatozoa involves segregation of most of the cytoplasm into residual bodies, which are detached from spermatids and eliminated in mammals. However, the molecular and cellular mechanism underlying the removal of residual bodies remains largely unknown. Here, we demonstrate that during C. elegans spermatogenesis residual bodies are engulfed and degraded by gonadal sheath cells, a process that uses the same set of genes underlying apoptotic cell removal. The two partially redundant engulfment pathways that clear cell corpses also mediate phagocytosis of residual bodies, possibly by recognizing the ′eat me′ signal phosphatidylserine exposed on the surface. The residual body-containing phagosome undergoes a maturation process involving sequential steps including dynamic coating with PtdIns(3) P and association of RAB small GTPases. The genetic hierarchy of residual body removal in hermaphrodites is similar to that of cell corpse clearance, but male residual body removal involves a distinct hierarchy, with differential use of the engulfment genes. Efficient removal of residual bodies regulates the number of spermatids and effective transfer of spermatids during male matings. Our results indicate that a similar molecular mechanism is employed for the removal of residual bodies and apoptotic cell corpses in C. elegans.

语种英语
所属项目编号2011CB910100 ; 2010CB835201
资助者National Basic Research Program of China ; Howard Hughes Medical Institute ; National Basic Research Program of China ; Howard Hughes Medical Institute
WOS记录号WOS:000311413900013
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54424
专题基础医学院_免疫学系
作者单位1.Natl Inst Biol Sci, Beijing 102206, Peoples R China
2.Chinese Acad Sci, Inst Biophys, State Key Lab Biomacromol, Beijing 100101, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100191, Peoples R China
4.China Agr Univ, Coll Life Sci, Beijing 100094, Peoples R China
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GB/T 7714
Huang, Jie,Wang, Haibin,Chen, Yingyu,et al. Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance[J]. DEVELOPMENT,2012,139(24):4613-4622.
APA Huang, Jie,Wang, Haibin,Chen, Yingyu,Wang, Xiaochen,&Zhang, Hong.(2012).Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance.DEVELOPMENT,139(24),4613-4622.
MLA Huang, Jie,et al."Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance".DEVELOPMENT 139.24(2012):4613-4622.
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