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学科主题: 药学
题名:
Synthesis of galactosyl and lactosyl derivatives as potential anti-metastasis compounds
作者: Li, H; Li, Q; Cai, MS; Li, ZJ
关键词: alpha-galactosyl trimannoside ; beta-lactosyl trimannoside ; glycosylation ; synthesis
刊名: CARBOHYDRATE RESEARCH
发表日期: 2000-10-06
卷: 328, 期:4, 页:611-615
收录类别: IC ; SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: MURINE MELANOMA-CELLS
英文摘要:

Based on the known anti-metastasis activities of lactosides and galactosides, a galactosyl and a lactosyl trimannoside were prepared via the conventional Koenigs-Knorr and trichloroacetimidate methods, respectively. Through typical deblocking procedures, a tetrasaccharide alpha-D-Galp-(1-->2)-alpha-D-Manp-(1-->2)-alpha-D-Manp-(1-->6)-alpha-D-ManpOCH(3) and a pentasaccharide beta-D-Galp-(1-->4)-beta-D-Glcp-(1-->2)-alpha-D-Manp-(1-->2)-alpha-D-Manp-(1-->6)-alpha-D-ManpOCH(3) were obtained. (C) 2000 Elsevier Science Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000089779000020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54426
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Beijing Med Univ, Sch Pharmaceut Sci, Dept Bioorgan Chem, Beijing 100083, Peoples R China

Recommended Citation:
Li, H,Li, Q,Cai, MS,et al. Synthesis of galactosyl and lactosyl derivatives as potential anti-metastasis compounds[J]. CARBOHYDRATE RESEARCH,2000,328(4):611-615.
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