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Identification of M Protein From Filter Paper Using Serum Protein and Immunofixation Electrophoresis
Wu, Yonghua1; Yang, Xu1; Wang, Tiancheng1; Wang, Haining2; Li, Zhenrong1
关键词Serum Protein Electrophoresis Immunofixation Electrophoresis m (Monoclonal) Protein Filter Paper
刊名AMERICAN JOURNAL OF CLINICAL PATHOLOGY
2012-10-01
DOI10.1309/AJCPFY6HLIT6HMQN
138期:4页:604-608
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]BLOOD SPOT SAMPLES ; MULTIPLE-MYELOMA ; MONOCLONAL GAMMOPATHIES ; STORAGE
英文摘要

Serum protein electrophoresis (SPE) and immunofixation electrophoresis (IFE) are standard methods for detection and monitoring of monoclonal (M) proteins. However, these tests are rarely available in the remote areas, especially in developing countries. Transportation of fresh serum (FS) samples is also usually inconvenient. This study investigated M-protein identification using serum blot on filter paper (FP). SPE and IFE were performed on FS and FP specimens using the Sebia Hydrasys automated electrophoresis system. Statistical analyses were conducted to assess sample stability and agreement of FS vs FP. The FP method showed good agreement with the FS method. The r values for correlation of albumin levels-alpha(1), alpha(2), beta, and gamma (%)-between FP and FS samples in SPE were all more than 0.95 (P < .01). IFE displayed no significant difference between those 2 methods in the identification of M protein. The FP method demonstrated an accurate and reproducible alternative to FS for identification of M protein using SPE and IFE.

语种英语
WOS记录号WOS:000309018000015
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54433
专题北京大学第三临床医学院
北京大学第三临床医学院_内分泌科
作者单位1.Peking Univ, Dept Lab Med, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Dept Endocrinol, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wu, Yonghua,Yang, Xu,Wang, Tiancheng,et al. Identification of M Protein From Filter Paper Using Serum Protein and Immunofixation Electrophoresis[J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY,2012,138(4):604-608.
APA Wu, Yonghua,Yang, Xu,Wang, Tiancheng,Wang, Haining,&Li, Zhenrong.(2012).Identification of M Protein From Filter Paper Using Serum Protein and Immunofixation Electrophoresis.AMERICAN JOURNAL OF CLINICAL PATHOLOGY,138(4),604-608.
MLA Wu, Yonghua,et al."Identification of M Protein From Filter Paper Using Serum Protein and Immunofixation Electrophoresis".AMERICAN JOURNAL OF CLINICAL PATHOLOGY 138.4(2012):604-608.
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