IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Sequence Fingerprints of MicroRNA Conservation
Shi, Bing1,2; Gao, Wei1; Wang, Juan2
刊名PLOS ONE
2012-10-24
DOI10.1371/journal.pone.0048256
7期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GC CONTENT EVOLUTION ; SIGNALING NETWORK ; PROTEIN EVOLUTION ; GENES ; SITES ; RNAS ; ROBUSTNESS ; DATABASE ; TARGETS ; ORIGIN
英文摘要

It is known that the conservation of protein-coding genes is associated with their sequences both various species, such as animals and plants. However, the association between microRNA (miRNA) conservation and their sequences in various species remains unexplored. Here we report the association of miRNA conservation with its sequence features, such as base content and cleavage sites, suggesting that miRNA sequences contain the fingerprints for miRNA conservation. More interestingly, different species show different and even opposite patterns between miRNA conservation and sequence features. For example, mammalian miRNAs show a positive/negative correlation between conservation and AU/GC content, whereas plant miRNAs show a negative/positive correlation between conservation and AU/GC content. Further analysis puts forward the hypothesis that the introns of protein-coding genes may be a main driving force for the origin and evolution of mammalian miRNAs. At the 5′ end, conserved miRNAs have a preference for base U, while less-conserved miRNAs have a preference for a non-U base in mammals. This difference does not exist in insects and plants, in which both conserved miRNAs and less-conserved miRNAs have a preference for base U at the 5′ end. We further revealed that the non-U preference at the 5′ end of less-conserved mammalian miRNAs is associated with miRNA function diversity, which may have evolved from the pressure of a highly sophisticated environmental stimulus the mammals encountered during evolution. These results indicated that miRNA sequences contain the fingerprints for conservation, and these fingerprints vary according to species. More importantly, the results suggest that although species share common mechanisms by which miRNAs originate and evolve, mammals may develop a novel mechanism for miRNA origin and evolution. In addition, the fingerprint found in this study can be predictor of miRNA conservation, and the findings are helpful in achieving a clearer understanding of miRNA function and evolution.

语种英语
WOS记录号WOS:000310310200162
项目编号81170225
资助机构NSFC
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54436
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Biomed Informat, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Shi, Bing,Gao, Wei,Wang, Juan. Sequence Fingerprints of MicroRNA Conservation[J]. PLOS ONE,2012,7(10).
APA Shi, Bing,Gao, Wei,&Wang, Juan.(2012).Sequence Fingerprints of MicroRNA Conservation.PLOS ONE,7(10).
MLA Shi, Bing,et al."Sequence Fingerprints of MicroRNA Conservation".PLOS ONE 7.10(2012).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shi, Bing]的文章
[Gao, Wei]的文章
[Wang, Juan]的文章
百度学术
百度学术中相似的文章
[Shi, Bing]的文章
[Gao, Wei]的文章
[Wang, Juan]的文章
必应学术
必应学术中相似的文章
[Shi, Bing]的文章
[Gao, Wei]的文章
[Wang, Juan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。