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Involvement of insular muscarinic cholinergic receptors in morphine-induced conditioned place preference in rats
Wu, Wei1; Li, Hui2; Liu, Yu1; Huang, Xinjie2; Chen, Lei2; Zhai, Haifeng2
关键词Addiction Memory Drug Reward Relapse Acetylcholine Receptor
刊名PSYCHOPHARMACOLOGY
2014-10-01
DOI10.1007/s00213-014-3550-1
231期:21页:4109-4118
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]TASTE MEMORY FORMATION ; LONG-TERM-MEMORY ; ACETYLCHOLINE-RECEPTORS ; BASOLATERAL AMYGDALA ; CONTEXTUAL MEMORY ; CORTEX ; ADDICTION ; SCOPOLAMINE ; CONSOLIDATION ; DISRUPTS
英文摘要

Drug addiction represents a pathological usurpation of neural processes involved in learning and memory. Retrieval of drug-related memories can result in drug craving and relapse. Recently, the insula was identified as part of the neuronal circuit responsible for the processing of drug memory; however, its precise role remains unclear.

To investigate the involvement of insular muscarinic acetylcholine receptors (mAChRs) in the processing of drug memory.

The morphine-induced conditioned place preference (CPP) was used to assess drug memory. All rats were first trained with morphine to establish the CPP. Sub-groups of these rats were used for contextual cue-induced CPP reinstatement. Other sub-groups of rats underwent extinction of the CPP, and 5 m/kg morphine was used for priming-induced CPP reinstatement. Microinjection of mAChR antagonists or agonists into the insula was performed prior to the CPP tests in order to evaluate their effect on CPP expression.

Insular microinjections of the nonselective mAChR antagonist, scopolamine, and the M-1 antagonist, pirenzepine, significantly inhibited CPP expression in both contextual cue- and priming-induced CPP reinstatement; the M-1 agonist, MCN-A-343, and the M-4 antagonist, tropicamide, enhanced CPP expression. The M-4 agonist, LY2033298, inhibited CPP expression. The M-2 antagonist, methoctramine, and M-3 antagonist, 4-DAMP, had no effect on CPP expression.

Our results demonstrate that insular mAChRs play a role in the processing of drug memory. M-1 and M-4 mAChRs work paradoxically; M-1 activation and M-4 inhibition attenuate the expression of drug memory, while M-1 inhibition and M-4 activation augment the expression of drug memory.

语种英语
WOS记录号WOS:000343721600003
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54439
专题中国药物依赖性研究所
作者单位1.Ningbo Univ, Sch Med, Ningbo 315010, Zhejiang, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wu, Wei,Li, Hui,Liu, Yu,et al. Involvement of insular muscarinic cholinergic receptors in morphine-induced conditioned place preference in rats[J]. PSYCHOPHARMACOLOGY,2014,231(21):4109-4118.
APA Wu, Wei,Li, Hui,Liu, Yu,Huang, Xinjie,Chen, Lei,&Zhai, Haifeng.(2014).Involvement of insular muscarinic cholinergic receptors in morphine-induced conditioned place preference in rats.PSYCHOPHARMACOLOGY,231(21),4109-4118.
MLA Wu, Wei,et al."Involvement of insular muscarinic cholinergic receptors in morphine-induced conditioned place preference in rats".PSYCHOPHARMACOLOGY 231.21(2014):4109-4118.
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