北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Involvement of insular muscarinic cholinergic receptors in morphine-induced conditioned place preference in rats
作者: Wu, Wei1; Li, Hui2; Liu, Yu1; Huang, Xinjie2; Chen, Lei2; Zhai, Haifeng2
关键词: Addiction memory ; Drug reward ; Relapse ; Acetylcholine receptor
刊名: PSYCHOPHARMACOLOGY
发表日期: 2014-10-01
DOI: 10.1007/s00213-014-3550-1
卷: 231, 期:21, 页:4109-4118
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: TASTE MEMORY FORMATION ; LONG-TERM-MEMORY ; ACETYLCHOLINE-RECEPTORS ; BASOLATERAL AMYGDALA ; CONTEXTUAL MEMORY ; CORTEX ; ADDICTION ; SCOPOLAMINE ; CONSOLIDATION ; DISRUPTS
英文摘要:

Drug addiction represents a pathological usurpation of neural processes involved in learning and memory. Retrieval of drug-related memories can result in drug craving and relapse. Recently, the insula was identified as part of the neuronal circuit responsible for the processing of drug memory; however, its precise role remains unclear.

To investigate the involvement of insular muscarinic acetylcholine receptors (mAChRs) in the processing of drug memory.

The morphine-induced conditioned place preference (CPP) was used to assess drug memory. All rats were first trained with morphine to establish the CPP. Sub-groups of these rats were used for contextual cue-induced CPP reinstatement. Other sub-groups of rats underwent extinction of the CPP, and 5 m/kg morphine was used for priming-induced CPP reinstatement. Microinjection of mAChR antagonists or agonists into the insula was performed prior to the CPP tests in order to evaluate their effect on CPP expression.

Insular microinjections of the nonselective mAChR antagonist, scopolamine, and the M-1 antagonist, pirenzepine, significantly inhibited CPP expression in both contextual cue- and priming-induced CPP reinstatement; the M-1 agonist, MCN-A-343, and the M-4 antagonist, tropicamide, enhanced CPP expression. The M-4 agonist, LY2033298, inhibited CPP expression. The M-2 antagonist, methoctramine, and M-3 antagonist, 4-DAMP, had no effect on CPP expression.

Our results demonstrate that insular mAChRs play a role in the processing of drug memory. M-1 and M-4 mAChRs work paradoxically; M-1 activation and M-4 inhibition attenuate the expression of drug memory, while M-1 inhibition and M-4 activation augment the expression of drug memory.

语种: 英语
所属项目编号: 30873051 ; 81271473 ; 7112087
项目资助者: National Science Foundation ; Beijing Municipal Natural Science Foundation of China
WOS记录号: WOS:000343721600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54439
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Ningbo Univ, Sch Med, Ningbo 315010, Zhejiang, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Wu, Wei,Li, Hui,Liu, Yu,et al. Involvement of insular muscarinic cholinergic receptors in morphine-induced conditioned place preference in rats[J]. PSYCHOPHARMACOLOGY,2014,231(21):4109-4118.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu, Wei]'s Articles
[Li, Hui]'s Articles
[Liu, Yu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu, Wei]‘s Articles
[Li, Hui]‘s Articles
[Liu, Yu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace