IR@PKUHSC  > 基础医学院  > 神经生物学系
学科主题基础医学
Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation
Liu, Ju Mei1; Pan, Feng1,2; Li, Li1; Liu, Qian Rong1; Chen, Yong1; Xiong, Xin Xin1; Cheng, Kejun3,4; Bin Yu, Shang1; Shi, Zhi5,6; Yu, Albert Cheung-Hoi7,8; Chen, Xiao Qian1
关键词Piplartine Glioma Oxidative stress Apoptosis Cancer therapy Brain tumor
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2013-07-19
DOI10.1016/j.bbrc.2013.06.042
437期:1页:87-93
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]PROTEIN-KINASE ; CANCER-CELLS ; 14-3-3-GAMMA ; NEUROGLOBIN ; ASTROCYTES ; APOPTOSIS ; ROS
英文摘要

Piperlongumine (PL), a natural alkaloid isolated from the long pepper, may have anti-cancer properties. It selectively targets and kills cancer cells but leaves normal cells intact. Here, we reported that PL selectively killed glioblastoma multiforme (GBM) cells via accumulating reactive oxygen species (ROS) to activate JNK and p38. PL at 20 mu M could induce severe cell death in three GBM cell lines (LN229, U87 and 8MG) but not astrocytes in cultures. PL elevated ROS prominently and reduced glutathione levels in LN229 and 1387 cells. Antioxidant N-acetyl-L-cysteine (NAC) completely reversed PL-induced ROS accumulation and prevented cell death in LN229 and U87 cells. In LN229 and 1387 cells, PL-treatment activated JNK and p38 but not Erk and Akt, in a dosage-dependent manner. These activations could be blocked by NAC pre-treatment. JNK and p38 specific inhibitors, SB203580 and SP600125 respectively, significantly blocked the cytotoxic effects of PL in LN229 and 1387 cells. Our data first suggests that PL may have therapeutic potential for one of the most malignant and refractory tumors GBM. (c) 2013 Elsevier Inc. All rights reserved.

语种英语
所属项目编号30570555 ; 81070937 ; 81172397 ; 81201726 ; 31271444
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000322353000015
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54443
专题基础医学院_神经生物学系
作者单位1.Huazhong Univ Sci & Technol, Sch Basic Med, Dept Pathophysiol,Minist Educ, Key Lab Neurol Dis,Hubei Prov Key Lab Neurolog Di, Wuhan 430030, Peoples R China
2.Huazhong Univ Sci & Technol, Union Hosp, Dept Urol, Wuhan 430030, Peoples R China
3.Lishui Inst Agr Sci, Chem Biol Ctr, Lishui, Zhejiang 323300, Peoples R China
4.Vatalis Tech LLC, Houston, TX 77054 USA
5.Jinan Univ, Dept Cell Biol, Guangzhou 510632, Guangdong, Peoples R China
6.Jinan Univ, Coll Life Sci, Inst Biomed, Guangzhou 510632, Guangdong, Peoples R China
7.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
8.Peking Univ, Sch Basic Med Sci, Key Lab Neurosci, Natl Hlth & Family Planning Commiss,Minist Educ, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Liu, Ju Mei,Pan, Feng,Li, Li,et al. Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,437(1):87-93.
APA Liu, Ju Mei.,Pan, Feng.,Li, Li.,Liu, Qian Rong.,Chen, Yong.,...&Chen, Xiao Qian.(2013).Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,437(1),87-93.
MLA Liu, Ju Mei,et al."Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 437.1(2013):87-93.
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