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学科主题: 药物依赖
题名:
Role of BDNF and GDNF in drug reward and relapse: A review
作者: Ghitza, Udi E.3; Zhai, Haifeng2; Wu, Ping2; Airavaara, Mikko1; Shaham, Yavin1; Lu, Lin2
关键词: Addiction ; Alcohol ; Cocaine ; Craving ; Drug self-administration ; Extinction ; Heroin ; Incubation ; Mesocorticolimbic dopamine system ; Neuroadaptations ; Relapse ; Reinstatement
刊名: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
发表日期: 2010-11-01
DOI: 10.1016/j.neubiorev.2009.11.009
卷: 35, 期:2, 页:157-171
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: MESOLIMBIC DOPAMINE SYSTEM ; VENTRAL TEGMENTAL AREA ; CONDITIONED-PLACE PREFERENCE ; CORTICOTROPIN-RELEASING-FACTOR ; COCAINE-SEEKING BEHAVIOR ; NEUROTROPHIC FACTOR EXPRESSION ; PRIMING-INDUCED REINSTATEMENT ; LONG-LASTING POTENTIATION ; STRESS-INDUCED RELAPSE ; NECROSIS-FACTOR-ALPHA
英文摘要:

Brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are neurotrophic factors that are critical for the growth, survival, and differentiation of developing neurons. These neurotrophic factors also play important roles in the survival and function of adult neurons, learning and memory, and synaptic plasticity. Since the mid-1990s, investigators have studied the role of BDNF and GDNF in the behavioral effects of abused drugs and in the neuroadaptations induced by repeated exposure to drugs in the mesocorticolimbic dopamine system. Here, we review rodent studies on the role of BDNF and GDNF in drug reward, as assessed in the drug self-administration and the conditioned place preference procedures, and in drug relapse, as assessed in extinction and reinstatement procedures. Our main conclusion is that whether BDNF or GDNF would facilitate or inhibit drug-taking behaviors depends on the drug type, the brain site, the addiction phase (initiation, maintenance, or abstinence/relapse), and the time interval between site-specific BDNF or GDNF injections and the reward- and relapse-related behavioral assessments. Published by Elsevier Ltd.

语种: 英语
所属项目编号: 2009CB522004 ; 30725016
项目资助者: National Basic Research Program of China ; Natural Science Foundation of China ; NIDA, NIH
WOS记录号: WOS:000284344900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54444
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.NIDA, Intramural Res Program, NIH, Baltimore, MD USA
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
3.NIDA, Ctr Clin Trials Network, NIH, Bethesda, MD 20892 USA

Recommended Citation:
Ghitza, Udi E.,Zhai, Haifeng,Wu, Ping,et al. Role of BDNF and GDNF in drug reward and relapse: A review[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2010,35(2):157-171.
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