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Role of BDNF and GDNF in drug reward and relapse: A review
Ghitza, Udi E.3; Zhai, Haifeng2; Wu, Ping2; Airavaara, Mikko1; Shaham, Yavin1; Lu, Lin2
关键词Addiction Alcohol Cocaine Craving Drug Self-administration Extinction Heroin Incubation Mesocorticolimbic Dopamine System Neuroadaptations Relapse Reinstatement
刊名NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
2010-11-01
DOI10.1016/j.neubiorev.2009.11.009
35期:2页:157-171
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]MESOLIMBIC DOPAMINE SYSTEM ; VENTRAL TEGMENTAL AREA ; CONDITIONED-PLACE PREFERENCE ; CORTICOTROPIN-RELEASING-FACTOR ; COCAINE-SEEKING BEHAVIOR ; NEUROTROPHIC FACTOR EXPRESSION ; PRIMING-INDUCED REINSTATEMENT ; LONG-LASTING POTENTIATION ; STRESS-INDUCED RELAPSE ; NECROSIS-FACTOR-ALPHA
英文摘要

Brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are neurotrophic factors that are critical for the growth, survival, and differentiation of developing neurons. These neurotrophic factors also play important roles in the survival and function of adult neurons, learning and memory, and synaptic plasticity. Since the mid-1990s, investigators have studied the role of BDNF and GDNF in the behavioral effects of abused drugs and in the neuroadaptations induced by repeated exposure to drugs in the mesocorticolimbic dopamine system. Here, we review rodent studies on the role of BDNF and GDNF in drug reward, as assessed in the drug self-administration and the conditioned place preference procedures, and in drug relapse, as assessed in extinction and reinstatement procedures. Our main conclusion is that whether BDNF or GDNF would facilitate or inhibit drug-taking behaviors depends on the drug type, the brain site, the addiction phase (initiation, maintenance, or abstinence/relapse), and the time interval between site-specific BDNF or GDNF injections and the reward- and relapse-related behavioral assessments. Published by Elsevier Ltd.

语种英语
WOS记录号WOS:000284344900004
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被引频次:99[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54444
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位1.NIDA, Intramural Res Program, NIH, Baltimore, MD USA
2.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
3.NIDA, Ctr Clin Trials Network, NIH, Bethesda, MD 20892 USA
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Ghitza, Udi E.,Zhai, Haifeng,Wu, Ping,et al. Role of BDNF and GDNF in drug reward and relapse: A review[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2010,35(2):157-171.
APA Ghitza, Udi E.,Zhai, Haifeng,Wu, Ping,Airavaara, Mikko,Shaham, Yavin,&Lu, Lin.(2010).Role of BDNF and GDNF in drug reward and relapse: A review.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,35(2),157-171.
MLA Ghitza, Udi E.,et al."Role of BDNF and GDNF in drug reward and relapse: A review".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 35.2(2010):157-171.
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