IR@PKUHSC  > 北京大学基础医学院  > 细胞生物学系
学科主题基础医学
Correlation of LAPTM4B Polymorphisms With Cervical Carcinoma
Meng, Fanling1; Song, Hongtao2; Luo, Chang3; Yin, Mingzhu1; Xu, Ye1; Liu, Haixia1; Zhou, Rouli4; Lou, Ge1
关键词Cervical Carcinoma Laptm4b Polymorphism Susceptibility
刊名CANCER
2011-06-15
DOI10.1002/cncr.25833
117期:12页:2652-2658
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HEPATOCELLULAR-CARCINOMA ; GENE POLYMORPHISM ; CIGARETTE-SMOKING ; CANCER STATISTICS ; NATURAL-HISTORY ; OVEREXPRESSION ; SUSCEPTIBILITY ; PROGRESSION ; EXPRESSION ; MARKER
英文摘要

BACKGROUND: Lysosome-associated protein transmembrane 4 beta (LAPTM4B), a novel oncoprotein, is overexpressed in several carcinomas. Previous studies revealed that LAPTM4B polymorphisms contribute to the risk of certain types of cancers. The purpose of this study was to investigate the association between different LAPTM4B alleles and the risk of cervical carcinoma. METHODS: A case-control analysis was performed in 317 patients with cervical cancer and 416 control subjects. Genomic DNA was extracted from peripheral blood lymphocytes in all participants. LAPTM4B genotypes were determined using polymerase chain reaction. Odds ratios and 95% confidence intervals (CIs) were computed using an unconditional logistic regression model. RESULTS: There was a significant difference (P<.001) in LAPTM4B*2 allele frequency between cervical cancer cases (35.8%) and controls (26.3%). There was also a significant difference in the overall genotypic distribution between patients and controls (P<.001). Using the LAPTM4B*1/1 genotype as a reference, we found that LAPTM4B allelic variation was associated with a significantly increased risk of cervical cancer, with adjusted odds ratios of 1.60 (95% CI, 1.15-2.22) and 2.12 (95% CI, 1.20-3.76) for the *1/2 and *2/2 genotype, respectively. Stratification analysis indicated that the association was more pronounced in younger subjects, smokers, premenopausal women, and women with more parities. Moreover, multiplicative joint effects were found between the *1/2 or *2/2 genotype and smoking. CONCLUSIONS: The findings of this study indicated that the LAPTM4B*2 allele might be a cervical cancer risk factor and may play an important role in genetic susceptibility to cervical cancer in the Chinese population. Cancer 2011; 117: 2652-8. (C) 2011 American Cancer Society.

语种英语
WOS记录号WOS:000291450100012
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被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54462
专题北京大学基础医学院_细胞生物学系
作者单位1.Harbin Med Univ, Affiliated Tumor Hosp, Dept Gynecol, Harbin 150081, Peoples R China
2.Harbin Med Univ, Affiliated Tumor Hosp, Dept Pathol, Harbin 150081, Peoples R China
3.Red Cross Cent Hosp, Dept Birth Control, Harbin, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100871, Peoples R China
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GB/T 7714
Meng, Fanling,Song, Hongtao,Luo, Chang,et al. Correlation of LAPTM4B Polymorphisms With Cervical Carcinoma[J]. CANCER,2011,117(12):2652-2658.
APA Meng, Fanling.,Song, Hongtao.,Luo, Chang.,Yin, Mingzhu.,Xu, Ye.,...&Lou, Ge.(2011).Correlation of LAPTM4B Polymorphisms With Cervical Carcinoma.CANCER,117(12),2652-2658.
MLA Meng, Fanling,et al."Correlation of LAPTM4B Polymorphisms With Cervical Carcinoma".CANCER 117.12(2011):2652-2658.
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