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学科主题: 基础医学
题名:
Correlation of LAPTM4B Polymorphisms With Cervical Carcinoma
作者: Meng, Fanling1; Song, Hongtao2; Luo, Chang3; Yin, Mingzhu1; Xu, Ye1; Liu, Haixia1; Zhou, Rouli4; Lou, Ge1
关键词: cervical carcinoma ; LAPTM4B ; polymorphism ; susceptibility
刊名: CANCER
发表日期: 2011-06-15
DOI: 10.1002/cncr.25833
卷: 117, 期:12, 页:2652-2658
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; GENE POLYMORPHISM ; CIGARETTE-SMOKING ; CANCER STATISTICS ; NATURAL-HISTORY ; OVEREXPRESSION ; SUSCEPTIBILITY ; PROGRESSION ; EXPRESSION ; MARKER
英文摘要:

BACKGROUND: Lysosome-associated protein transmembrane 4 beta (LAPTM4B), a novel oncoprotein, is overexpressed in several carcinomas. Previous studies revealed that LAPTM4B polymorphisms contribute to the risk of certain types of cancers. The purpose of this study was to investigate the association between different LAPTM4B alleles and the risk of cervical carcinoma. METHODS: A case-control analysis was performed in 317 patients with cervical cancer and 416 control subjects. Genomic DNA was extracted from peripheral blood lymphocytes in all participants. LAPTM4B genotypes were determined using polymerase chain reaction. Odds ratios and 95% confidence intervals (CIs) were computed using an unconditional logistic regression model. RESULTS: There was a significant difference (P<.001) in LAPTM4B*2 allele frequency between cervical cancer cases (35.8%) and controls (26.3%). There was also a significant difference in the overall genotypic distribution between patients and controls (P<.001). Using the LAPTM4B*1/1 genotype as a reference, we found that LAPTM4B allelic variation was associated with a significantly increased risk of cervical cancer, with adjusted odds ratios of 1.60 (95% CI, 1.15-2.22) and 2.12 (95% CI, 1.20-3.76) for the *1/2 and *2/2 genotype, respectively. Stratification analysis indicated that the association was more pronounced in younger subjects, smokers, premenopausal women, and women with more parities. Moreover, multiplicative joint effects were found between the *1/2 or *2/2 genotype and smoking. CONCLUSIONS: The findings of this study indicated that the LAPTM4B*2 allele might be a cervical cancer risk factor and may play an important role in genetic susceptibility to cervical cancer in the Chinese population. Cancer 2011; 117: 2652-8. (C) 2011 American Cancer Society.

语种: 英语
WOS记录号: WOS:000291450100012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54462
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Harbin Med Univ, Affiliated Tumor Hosp, Dept Gynecol, Harbin 150081, Peoples R China
2.Harbin Med Univ, Affiliated Tumor Hosp, Dept Pathol, Harbin 150081, Peoples R China
3.Red Cross Cent Hosp, Dept Birth Control, Harbin, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100871, Peoples R China

Recommended Citation:
Meng, Fanling,Song, Hongtao,Luo, Chang,et al. Correlation of LAPTM4B Polymorphisms With Cervical Carcinoma[J]. CANCER,2011,117(12):2652-2658.
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