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学科主题: 精神卫生
题名:
Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population
作者: Wu, Suping; Yue, Weihua; Jia, Meixiang; Ruan, Yan; Lu, Tianlan; Gong, Xiaohong; Shuang, Mei; Liu, Jing; Yang, Xiaoling; Zhang, Dai
关键词: single nucleotide polymorphism (SNP) ; transmission disequilibrium test (TDT) ; haplotype
刊名: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
发表日期: 2007-06-05
DOI: 10.1002/ajmg.b.30495
卷: 144B, 期:4, 页:492-495
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Psychiatry
研究领域[WOS]: Genetics & Heredity ; Psychiatry
关键词[WOS]: RECEPTOR SUBUNIT GENES ; GENOMEWIDE SCREEN ; DISORDER ; LINKAGE ; 7Q
英文摘要:

Autism is a pervasive neurodevelopmental disorder, with a significant role of genetic factors in its development. The neuropilin-2 (NRP2) gene is localized to 2q34, an autism susceptibility locus. NRP2 has been demonstrated to both guide axons and to control neuronal migration in the central nervous system. It has been reported that NRP2 may be required in vivo for sorting migrating cortical and striatal interneurons to their correct destination. We examine the association between the NRP2 gene and autism using a cohort of 169 Chinese Han family trios. Four single nucleotide polymorphisms (SNPs) were genotyped by the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analyses. The transmission disequilibrium. tests (TDT) of SNPs and haplotype association were carried out using the TDTPHASE program. We found significant genetic association between autism and two of the SNPs of the NRP2 gene (rs849578: P = 0.017, rs849563: P = 0.027), as well as specific haplotypes, especially those formed by rs849563. Furthermore, haplotypes constructed with all markers showed significant excess transmission in both global and individual haplotype analyses (P=0.004 and 0.017, respectively). The polymorphisms in the NR.P2 gene are associated with autism, implying that the NRP2 gene may render individuals to be predisposed to autism. (c) 2007 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000246982700016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54463
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Wu, Suping,Yue, Weihua,Jia, Meixiang,et al. Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2007,144B(4):492-495.
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