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Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population
Wu, Suping; Yue, Weihua; Jia, Meixiang; Ruan, Yan; Lu, Tianlan; Gong, Xiaohong; Shuang, Mei; Liu, Jing; Yang, Xiaoling; Zhang, Dai
关键词Single Nucleotide Polymorphism (Snp) Transmission Disequilibrium Test (Tdt) Haplotype
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2007-06-05
DOI10.1002/ajmg.b.30495
144B期:4页:492-495
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]RECEPTOR SUBUNIT GENES ; GENOMEWIDE SCREEN ; DISORDER ; LINKAGE ; 7Q
英文摘要

Autism is a pervasive neurodevelopmental disorder, with a significant role of genetic factors in its development. The neuropilin-2 (NRP2) gene is localized to 2q34, an autism susceptibility locus. NRP2 has been demonstrated to both guide axons and to control neuronal migration in the central nervous system. It has been reported that NRP2 may be required in vivo for sorting migrating cortical and striatal interneurons to their correct destination. We examine the association between the NRP2 gene and autism using a cohort of 169 Chinese Han family trios. Four single nucleotide polymorphisms (SNPs) were genotyped by the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analyses. The transmission disequilibrium. tests (TDT) of SNPs and haplotype association were carried out using the TDTPHASE program. We found significant genetic association between autism and two of the SNPs of the NRP2 gene (rs849578: P = 0.017, rs849563: P = 0.027), as well as specific haplotypes, especially those formed by rs849563. Furthermore, haplotypes constructed with all markers showed significant excess transmission in both global and individual haplotype analyses (P=0.004 and 0.017, respectively). The polymorphisms in the NR.P2 gene are associated with autism, implying that the NRP2 gene may render individuals to be predisposed to autism. (c) 2007 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000246982700016
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被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54463
专题北京大学精神卫生研究所
作者单位Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
推荐引用方式
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Wu, Suping,Yue, Weihua,Jia, Meixiang,et al. Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2007,144B(4):492-495.
APA Wu, Suping.,Yue, Weihua.,Jia, Meixiang.,Ruan, Yan.,Lu, Tianlan.,...&Zhang, Dai.(2007).Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,144B(4),492-495.
MLA Wu, Suping,et al."Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 144B.4(2007):492-495.
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