IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Erythrocyte permeability to urea and water: comparative study in rodents, ruminants, carnivores, humans, and birds
Liu, Lifeng2,4; Lei, Tianluo1; Bankir, Lise3; Zhao, Dan2; Gai, Xiaodong4; Zhao, Xuejian2; Yang, Baoxue1,2
关键词Urea Urea Transport Erythrocyte Comparative Physiology
刊名JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY
2011
DOI10.1007/s00360-010-0515-5
181期:1页:65-72
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Physiology ; Zoology
研究领域[WOS]Physiology ; Zoology
关键词[WOS]URINARY CONCENTRATING ABILITY ; MICE LACKING AQUAPORIN-1 ; TRANSPORTER UT-B ; RED-BLOOD-CELLS ; MAMMALS ; EXPRESSION ; CLONING ; LOCALIZATION ; METABOLISM ; EXCRETION
英文摘要

Mammalian erythrocytes exhibit high urea permeability (P-urea) due to UT-B expression in their cytoplasmic membrane. This high P-urea allows fast equilibration of urea in erythrocytes during their transit in the hyperosmotic renal medulla. It also allows more urea (in addition to that in plasma) to participate in counter-current exchange between ascending and descending vasa recta, thus improving the trapping of urea in the medulla and improving urine concentrating ability. To determine if P-urea in erythrocytes is related to diet and urine concentrating ability, we measured P-urea in erythrocytes from 11 different mammals and 5 birds using stopped-flow light scattering. Carnivores (dog, fox, cat) exhibited high P-urea (in x10(-5) cm/s, 5.3 +/- 0.6, 3.8 +/- 0.5 and 2.8 +/- 0.7, respectively). In contrast, herbivores (cow, donkey, sheep) showed much lower P-urea (0.8 +/- 0.2, 0.7 +/- 0.2, 1.0 +/- 0.1, respectively). Erythrocyte P-urea in human (1.1 +/- 0.2), and pig (1.5 +/- 0.1), the two omnivores, was intermediate. Rodents and lagomorphs (mouse, rat, rabbit) had P-urea intermediate between carnivores and omnivores (3.3 +/- 0.4, 2.5 +/- 0.3 and 2.4 +/- 0.3, respectively). Birds that do not excrete urea and do not express UT-B in their erythrocytes had very low values (< 0.1 x 10(-5) cm/s). In contrast to P-urea, water permeability, measured simultaneously, was relatively similar in all mammals. The species differences in erythrocytes P-urea most probably reflect adaptation to the different types of diet and resulting different needs for concentrating urea in the urine.

语种英语
WOS记录号WOS:000286341400006
项目编号30870921 ; 985-2-094-121
资助机构National Natural Science Foundation of China ; Ministry of Education of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54470
专题北京大学基础医学院_药理学系
作者单位1.Jilin Univ, Dept Pathophysiol, Changchun 130023, Peoples R China
2.Beihua Univ, Beijing, Jilin, Peoples R China
3.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China
4.INSERM, UMRS 872, Ctr Rech Cordeliers, Paris, France
推荐引用方式
GB/T 7714
Liu, Lifeng,Lei, Tianluo,Bankir, Lise,et al. Erythrocyte permeability to urea and water: comparative study in rodents, ruminants, carnivores, humans, and birds[J]. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY,2011,181(1):65-72.
APA Liu, Lifeng.,Lei, Tianluo.,Bankir, Lise.,Zhao, Dan.,Gai, Xiaodong.,...&Yang, Baoxue.(2011).Erythrocyte permeability to urea and water: comparative study in rodents, ruminants, carnivores, humans, and birds.JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY,181(1),65-72.
MLA Liu, Lifeng,et al."Erythrocyte permeability to urea and water: comparative study in rodents, ruminants, carnivores, humans, and birds".JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY 181.1(2011):65-72.
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