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学科主题: 基础医学
题名:
Erythrocyte permeability to urea and water: comparative study in rodents, ruminants, carnivores, humans, and birds
作者: Liu, Lifeng2,4; Lei, Tianluo1; Bankir, Lise3; Zhao, Dan2; Gai, Xiaodong4; Zhao, Xuejian2; Yang, Baoxue1,2
关键词: Urea ; Urea transport ; Erythrocyte ; Comparative physiology
刊名: JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY
发表日期: 2011
DOI: 10.1007/s00360-010-0515-5
卷: 181, 期:1, 页:65-72
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Physiology ; Zoology
研究领域[WOS]: Physiology ; Zoology URINARY CONCENTRATING ABILITY ; MICE LACKING AQUAPORIN-1 ; TRANSPORTER UT-B ; RED-BLOOD-CELLS ; MAMMALS ; EXPRESSION ; CLONING ; LOCALIZATION ; METABOLISM ; EXCRETION
英文摘要:

Mammalian erythrocytes exhibit high urea permeability (P-urea) due to UT-B expression in their cytoplasmic membrane. This high P-urea allows fast equilibration of urea in erythrocytes during their transit in the hyperosmotic renal medulla. It also allows more urea (in addition to that in plasma) to participate in counter-current exchange between ascending and descending vasa recta, thus improving the trapping of urea in the medulla and improving urine concentrating ability. To determine if P-urea in erythrocytes is related to diet and urine concentrating ability, we measured P-urea in erythrocytes from 11 different mammals and 5 birds using stopped-flow light scattering. Carnivores (dog, fox, cat) exhibited high P-urea (in x10(-5) cm/s, 5.3 +/- 0.6, 3.8 +/- 0.5 and 2.8 +/- 0.7, respectively). In contrast, herbivores (cow, donkey, sheep) showed much lower P-urea (0.8 +/- 0.2, 0.7 +/- 0.2, 1.0 +/- 0.1, respectively). Erythrocyte P-urea in human (1.1 +/- 0.2), and pig (1.5 +/- 0.1), the two omnivores, was intermediate. Rodents and lagomorphs (mouse, rat, rabbit) had P-urea intermediate between carnivores and omnivores (3.3 +/- 0.4, 2.5 +/- 0.3 and 2.4 +/- 0.3, respectively). Birds that do not excrete urea and do not express UT-B in their erythrocytes had very low values (< 0.1 x 10(-5) cm/s). In contrast to P-urea, water permeability, measured simultaneously, was relatively similar in all mammals. The species differences in erythrocytes P-urea most probably reflect adaptation to the different types of diet and resulting different needs for concentrating urea in the urine.

语种: 英语
所属项目编号: 30870921 ; 985-2-094-121
项目资助者: National Natural Science Foundation of China ; Ministry of Education of China
WOS记录号: WOS:000286341400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54470
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Jilin Univ, Dept Pathophysiol, Changchun 130023, Peoples R China
2.Beihua Univ, Beijing, Jilin, Peoples R China
3.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China
4.INSERM, UMRS 872, Ctr Rech Cordeliers, Paris, France

Recommended Citation:
Liu, Lifeng,Lei, Tianluo,Bankir, Lise,et al. Erythrocyte permeability to urea and water: comparative study in rodents, ruminants, carnivores, humans, and birds[J]. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY,2011,181(1):65-72.
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