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学科主题: 临床医学
题名:
Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population
作者: Zhang, Jufeng1,2; Deng, Jingui1; Zhang, Chao1; Lu, Yanxin1; Liu, Li1; Wu, Qi1; Shao, Yong1,3; Zhang, Jie3; Yang, Hong1,4; Yu, Bo1,3; Wan, Jun1
关键词: Systemic lupus erythematosus ; GSTT1 ; GSTM1 ; CYP1A1 ; Gene polymorphisms
刊名: CLINICA CHIMICA ACTA
发表日期: 2010-06-03
DOI: 10.1016/j.cca.2010.03.007
卷: 411, 期:11-12, 页:878-881
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: GLUTATHIONE TRANSFERASES ; GENETIC POLYMORPHISMS ; BREAST-CANCER ; RISK ; SLE ; EXPOSURE ; PROMOTER ; LOCI
英文摘要:

Background: GSTT1, GSTM1, CYP1A1 are enzymes responsible for the detoxification of the toxicant which may be involved in the development of systemic lupus erythematosus (SLE). We examined the relationship between the risk of SLE and the polymorphisms of these genes in the Chinese population.

Methods: Samples from 298 SLE patients and 284 healthy controls were collected. Polymerase chain reaction-restriction fragments length polymorphism (PCR-RFLP) was used to analyze the genotypes of CYP1A1 m2 and m4, while multiplex PCR was used to analyze the genotypes of GSTT1 and GSTM1.

Results: Statistically significant difference was observed in genotypes for GSTM1 (p = 0.003, OR 1.66 [95% CI 1.19-2.32]), but not for GSTT1 (p = 0.119, OR 0.77 [95% CI 0.56-1.07]), in the SLE patients as compared with the controls. Combinational analysis for double-null deletion of both GSTT1 and GSTM1 showed no significant difference (p = 0.863, OR 1.03 [95% CI 0.70-1.52]). Significant difference was observed in the genotype frequencies (p = 0.013), but not in the allele frequencies (p = 0.444, OR 0.90 [95% CI 0.70-1.17]), of CYP1A1 m2. All candidates have a wild-type genotype for CYP1A1 m4.

Conclusions: Polymorphisms of GSTM1 are associated with SLE in the Chinese population. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 20080440778 ; 08fz-11
项目资助者: China Postdoctoral Science Foundation ; Shenzhen Science and Technology Foundation
WOS记录号: WOS:000277864200016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54471
Appears in Collections:北京大学深圳医院_皮肤性病科_期刊论文

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作者单位: 1.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
2.Guangdong Pharmaceut Univ, Sch Life Sci, Guangzhou 510006, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen 518036, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen 518036, Peoples R China

Recommended Citation:
Zhang, Jufeng,Deng, Jingui,Zhang, Chao,et al. Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population[J]. CLINICA CHIMICA ACTA,2010,411(11-12):878-881.
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