IR@PKUHSC  > 北京大学深圳医院  > 皮肤性病科
学科主题临床医学
Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population
Zhang, Jufeng1,2; Deng, Jingui1; Zhang, Chao1; Lu, Yanxin1; Liu, Li1; Wu, Qi1; Shao, Yong1,3; Zhang, Jie3; Yang, Hong1,4; Yu, Bo1,3; Wan, Jun1
关键词Systemic Lupus Erythematosus Gstt1 Gstm1 Cyp1a1 Gene Polymorphisms
刊名CLINICA CHIMICA ACTA
2010-06-03
DOI10.1016/j.cca.2010.03.007
411期:11-12页:878-881
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]GLUTATHIONE TRANSFERASES ; GENETIC POLYMORPHISMS ; BREAST-CANCER ; RISK ; SLE ; EXPOSURE ; PROMOTER ; LOCI
英文摘要

Background: GSTT1, GSTM1, CYP1A1 are enzymes responsible for the detoxification of the toxicant which may be involved in the development of systemic lupus erythematosus (SLE). We examined the relationship between the risk of SLE and the polymorphisms of these genes in the Chinese population.

Methods: Samples from 298 SLE patients and 284 healthy controls were collected. Polymerase chain reaction-restriction fragments length polymorphism (PCR-RFLP) was used to analyze the genotypes of CYP1A1 m2 and m4, while multiplex PCR was used to analyze the genotypes of GSTT1 and GSTM1.

Results: Statistically significant difference was observed in genotypes for GSTM1 (p = 0.003, OR 1.66 [95% CI 1.19-2.32]), but not for GSTT1 (p = 0.119, OR 0.77 [95% CI 0.56-1.07]), in the SLE patients as compared with the controls. Combinational analysis for double-null deletion of both GSTT1 and GSTM1 showed no significant difference (p = 0.863, OR 1.03 [95% CI 0.70-1.52]). Significant difference was observed in the genotype frequencies (p = 0.013), but not in the allele frequencies (p = 0.444, OR 0.90 [95% CI 0.70-1.17]), of CYP1A1 m2. All candidates have a wild-type genotype for CYP1A1 m4.

Conclusions: Polymorphisms of GSTM1 are associated with SLE in the Chinese population. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000277864200016
项目编号20080440778 ; 08fz-11
资助机构China Postdoctoral Science Foundation ; Shenzhen Science and Technology Foundation
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54471
专题北京大学深圳医院_皮肤性病科
北京大学临床肿瘤学院_护理部
作者单位1.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
2.Guangdong Pharmaceut Univ, Sch Life Sci, Guangzhou 510006, Guangdong, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen 518036, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen 518036, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jufeng,Deng, Jingui,Zhang, Chao,et al. Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population[J]. CLINICA CHIMICA ACTA,2010,411(11-12):878-881.
APA Zhang, Jufeng.,Deng, Jingui.,Zhang, Chao.,Lu, Yanxin.,Liu, Li.,...&Wan, Jun.(2010).Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population.CLINICA CHIMICA ACTA,411(11-12),878-881.
MLA Zhang, Jufeng,et al."Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population".CLINICA CHIMICA ACTA 411.11-12(2010):878-881.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Jufeng]的文章
[Deng, Jingui]的文章
[Zhang, Chao]的文章
百度学术
百度学术中相似的文章
[Zhang, Jufeng]的文章
[Deng, Jingui]的文章
[Zhang, Chao]的文章
必应学术
必应学术中相似的文章
[Zhang, Jufeng]的文章
[Deng, Jingui]的文章
[Zhang, Chao]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。