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学科主题: 基础医学
题名:
Higher dN/dS ratios in the HCV core gene, but not in the E1/HVR1 gene, are associated with human immunodeficiency virus-associated immunosuppression
作者: Xu, Chun-Hui1; Shen, Tao1; Zheng, Jia-Jia1; Tu, Jing1; Zhang, Wei-Dong2; Lu, Feng-Min1
刊名: ARCHIVES OF VIROLOGY
发表日期: 2012-11-01
DOI: 10.1007/s00705-012-1390-z
卷: 157, 期:11, 页:2153-2162
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: HEPATITIS-C-VIRUS ; INFECTION ; HIV ; CHIMPANZEES ; IMPACT ; IMMUNIZATION ; MANAGEMENT ; DIVERSITY ; DIAGNOSIS ; THERAPY
英文摘要:

Coinfection with HCV and HIV is prevalent among former commercial blood donors in some rural areas in China. Genetic variability of the HCV core and E1/HVR1 was investigated in 23 patients chronically infected with HCV-1b, with or without concomitant HIV infection. Genetic variability in the core sequence was higher under HIV-associated immunocompromised conditions. Both the Shannon entropy values at each nucleotide position and the dN/dS values at each codon were statistically higher in HIV/HCV-coinfected patients with lower CD4+ T cell counts (p-values were < 0.0001 and equal to 0.0372, respectively). The more significant difference of dN/dS value occurred in a specific subregion of the core gene that is enriched in CTL/Th epitopes (p = 0.0083). The dN/dS values of full-length core antigen were found to be negatively correlated with the S/CO ratio of plasma anti-HCV antibodies. By contrast, no significant difference in genetic diversity/complexity and dN/dS values in the E1/HVR1 region was found between those two groups. These results suggest that the dN/dS ratio in the core gene, but not in the E1/HVR1 gene, is influenced more by host CD4+ T cell-mediated cellular immunity.

语种: 英语
所属项目编号: 2012ZX10002003 ; 2012ZX10002005 ; 7122108 ; 20100001120047
项目资助者: National Science and Technology Major Project for Infectious Diseases ; National Science Foundation of Beijing ; Doctoral Program of Higher Education of China
WOS记录号: WOS:000310611100011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54475
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol, Zhengzhou 450001, Henan, Peoples R China

Recommended Citation:
Xu, Chun-Hui,Shen, Tao,Zheng, Jia-Jia,et al. Higher dN/dS ratios in the HCV core gene, but not in the E1/HVR1 gene, are associated with human immunodeficiency virus-associated immunosuppression[J]. ARCHIVES OF VIROLOGY,2012,157(11):2153-2162.
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