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学科主题: 临床医学
题名:
Role of Schwann cells in the regeneration of penile and peripheral nerves
作者: Wang, Lin1,2; Sanford, Melissa T.1; Xin, Zhongcheng2; Lin, Guiting1; Lue, Tom F.1
关键词: erectile dysfunction ; growth factors ; prostatectomy
刊名: ASIAN JOURNAL OF ANDROLOGY
发表日期: 2015-09-01
DOI: 10.4103/1008-682X.154306
卷: 17, 期:5, 页:776-782
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Andrology ; Urology & Nephrology
研究领域[WOS]: Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; RADICAL RETROPUBIC PROSTATECTOMY ; ERECTILE FUNCTION RECOVERY ; MAJOR PELVIC GANGLIA ; SHOCK-WAVE TREATMENT ; NEUROTROPHIC FACTOR ; CAVERNOUS NERVE ; WALLERIAN DEGENERATION ; RAT MODEL ; TRANSCRIPTIONAL CONTROL
英文摘要:

Schwann cells (SCs) are the principal glia of the peripheral nervous system. The end point of SC development is the formation of myelinating and nonmyelinating cells which ensheath large and small diameter axons, respectively. They play an important role in axon regeneration after injury, including cavernous nerve injury that leads to erectile dysfunction (ED). Despite improvement in radical prostatectomy surgical techniques, many patients still suffer from ED postoperatively as surgical trauma causes traction injuries and local inflammatory changes in the neuronal microenvironment of the autonomic fibers innervating the penis resulting in pathophysiological alterations in the end organ. The aim of this review is to summarize contemporary evidence regarding: (1) the origin and development of SCs in the peripheral and penile nerve system; (2) Wallerian degeneration and SC plastic change following peripheral and penile nerve injury; (3) how SCs promote peripheral and penile nerve regeneration by secreting neurotrophic factors; (4) and strategies targeting SCs to accelerate peripheral nerve regeneration. We searched PubMed for articles related to these topics in both animal models and human research and found numerous studies suggesting that SCs could be a novel target for treatment of nerve injury-induced ED.

语种: 英语
WOS记录号: WOS:000360628800019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54481
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Univ Calif San Francisco, Sch Med, Dept Urol, Knuppe Mol Urol Lab, San Francisco, CA 94143 USA
2.Peking Univ, Dept Urol, Androl Ctr, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Lin,Sanford, Melissa T.,Xin, Zhongcheng,et al. Role of Schwann cells in the regeneration of penile and peripheral nerves[J]. ASIAN JOURNAL OF ANDROLOGY,2015,17(5):776-782.
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