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学科主题临床医学
Role of Schwann cells in the regeneration of penile and peripheral nerves
Wang, Lin1,2; Sanford, Melissa T.1; Xin, Zhongcheng2; Lin, Guiting1; Lue, Tom F.1
关键词Erectile Dysfunction Growth Factors Prostatectomy
刊名ASIAN JOURNAL OF ANDROLOGY
2015-09-01
DOI10.4103/1008-682X.154306
17期:5页:776-782
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Andrology ; Urology & Nephrology
研究领域[WOS]Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; RADICAL RETROPUBIC PROSTATECTOMY ; ERECTILE FUNCTION RECOVERY ; MAJOR PELVIC GANGLIA ; SHOCK-WAVE TREATMENT ; NEUROTROPHIC FACTOR ; CAVERNOUS NERVE ; WALLERIAN DEGENERATION ; RAT MODEL ; TRANSCRIPTIONAL CONTROL
英文摘要

Schwann cells (SCs) are the principal glia of the peripheral nervous system. The end point of SC development is the formation of myelinating and nonmyelinating cells which ensheath large and small diameter axons, respectively. They play an important role in axon regeneration after injury, including cavernous nerve injury that leads to erectile dysfunction (ED). Despite improvement in radical prostatectomy surgical techniques, many patients still suffer from ED postoperatively as surgical trauma causes traction injuries and local inflammatory changes in the neuronal microenvironment of the autonomic fibers innervating the penis resulting in pathophysiological alterations in the end organ. The aim of this review is to summarize contemporary evidence regarding: (1) the origin and development of SCs in the peripheral and penile nerve system; (2) Wallerian degeneration and SC plastic change following peripheral and penile nerve injury; (3) how SCs promote peripheral and penile nerve regeneration by secreting neurotrophic factors; (4) and strategies targeting SCs to accelerate peripheral nerve regeneration. We searched PubMed for articles related to these topics in both animal models and human research and found numerous studies suggesting that SCs could be a novel target for treatment of nerve injury-induced ED.

语种英语
WOS记录号WOS:000360628800019
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54481
专题北京大学第一临床医学院_泌尿外科
作者单位1.Univ Calif San Francisco, Sch Med, Dept Urol, Knuppe Mol Urol Lab, San Francisco, CA 94143 USA
2.Peking Univ, Dept Urol, Androl Ctr, Hosp 1, Beijing 100871, Peoples R China
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Wang, Lin,Sanford, Melissa T.,Xin, Zhongcheng,et al. Role of Schwann cells in the regeneration of penile and peripheral nerves[J]. ASIAN JOURNAL OF ANDROLOGY,2015,17(5):776-782.
APA Wang, Lin,Sanford, Melissa T.,Xin, Zhongcheng,Lin, Guiting,&Lue, Tom F..(2015).Role of Schwann cells in the regeneration of penile and peripheral nerves.ASIAN JOURNAL OF ANDROLOGY,17(5),776-782.
MLA Wang, Lin,et al."Role of Schwann cells in the regeneration of penile and peripheral nerves".ASIAN JOURNAL OF ANDROLOGY 17.5(2015):776-782.
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