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Antifungal susceptibility and genotypes of Candida albicans strains from patients with vulvovaginal candidiasis
Liu, X. P.2; Fan, S. R.1; Bai, F. Y.3; Li, J.3; Liao, Q. P.4
关键词Candida Albicans Genotype Antifungal Susceptibility
刊名MYCOSES
2009
DOI10.1111/j.1439-0507.2008.01539.x
52期:1页:24-28
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology ; Mycology
研究领域[WOS]Dermatology ; Mycology
关键词[WOS]FLUCONAZOLE-RESISTANT ; IN-VITRO ; MICROSATELLITE ; MECHANISMS ; REVEALS ; CLADE ; GENE ; VIVO ; CDR1
英文摘要

Studies of the genetic diversity of Candida albicans strains and the correlation between the antifungal susceptibility and gene diversity of C. albicans were carried out and the results were found to be inconsistent. To investigate antifungal susceptibility and genotypes of C. albicans strains from patients with vulvovaginal candidiasis (VVC), the genotypes of C. albicans in patients with VVC were studied using a recently developed polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) of CAI microsatellite method and antifungal susceptibility was tested using E-test methods. Twenty-six genotypes were identified from 89 strains of C. albicans isolated from patients with VVC. Candida albicans isolates were susceptible to amphotericin B, flucytosine, ketoconazole and fluconazole. The dominant genotypes (A, B, C, D) account for 69.7% (62/89) of C. albicans. The resistant rate of C. albicans genotype B to itraconazole (ITR) and that of C. albicans non-genotype B strains were 66.7% (14/21) and 4.4% (3/68) respectively at P < 0.05. We concluded that C. albicans genotype B from patients with VVC was more resistant to ITR.

语种英语
WOS记录号WOS:000261616800004
项目编号2004BA720A05-01 ; JA 200505270419B ; 200702108 ; 200703031
资助机构National Key Technologies R D Programme ; Shenzhen Science and Technology
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54482
专题北京大学深圳医院
作者单位1.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen 518036, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen 518036, Peoples R China
3.Chinese Acad Sci, Inst Microbiol, Systemat Mycol & Lichenol Lab, Beijing, Peoples R China
4.Peking Univ First Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Liu, X. P.,Fan, S. R.,Bai, F. Y.,et al. Antifungal susceptibility and genotypes of Candida albicans strains from patients with vulvovaginal candidiasis[J]. MYCOSES,2009,52(1):24-28.
APA Liu, X. P.,Fan, S. R.,Bai, F. Y.,Li, J.,&Liao, Q. P..(2009).Antifungal susceptibility and genotypes of Candida albicans strains from patients with vulvovaginal candidiasis.MYCOSES,52(1),24-28.
MLA Liu, X. P.,et al."Antifungal susceptibility and genotypes of Candida albicans strains from patients with vulvovaginal candidiasis".MYCOSES 52.1(2009):24-28.
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