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学科主题: 临床医学
题名:
Antifungal susceptibility and genotypes of Candida albicans strains from patients with vulvovaginal candidiasis
作者: Liu, X. P.2; Fan, S. R.1; Bai, F. Y.3; Li, J.3; Liao, Q. P.4
关键词: Candida albicans ; genotype ; antifungal susceptibility
刊名: MYCOSES
发表日期: 2009
DOI: 10.1111/j.1439-0507.2008.01539.x
卷: 52, 期:1, 页:24-28
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology ; Mycology
研究领域[WOS]: Dermatology ; Mycology
关键词[WOS]: FLUCONAZOLE-RESISTANT ; IN-VITRO ; MICROSATELLITE ; MECHANISMS ; REVEALS ; CLADE ; GENE ; VIVO ; CDR1
英文摘要:

Studies of the genetic diversity of Candida albicans strains and the correlation between the antifungal susceptibility and gene diversity of C. albicans were carried out and the results were found to be inconsistent. To investigate antifungal susceptibility and genotypes of C. albicans strains from patients with vulvovaginal candidiasis (VVC), the genotypes of C. albicans in patients with VVC were studied using a recently developed polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) of CAI microsatellite method and antifungal susceptibility was tested using E-test methods. Twenty-six genotypes were identified from 89 strains of C. albicans isolated from patients with VVC. Candida albicans isolates were susceptible to amphotericin B, flucytosine, ketoconazole and fluconazole. The dominant genotypes (A, B, C, D) account for 69.7% (62/89) of C. albicans. The resistant rate of C. albicans genotype B to itraconazole (ITR) and that of C. albicans non-genotype B strains were 66.7% (14/21) and 4.4% (3/68) respectively at P < 0.05. We concluded that C. albicans genotype B from patients with VVC was more resistant to ITR.

语种: 英语
所属项目编号: 2004BA720A05-01 ; JA 200505270419B ; 200702108 ; 200703031
项目资助者: National Key Technologies R D Programme ; Shenzhen Science and Technology
WOS记录号: WOS:000261616800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54482
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen 518036, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen 518036, Peoples R China
3.Chinese Acad Sci, Inst Microbiol, Systemat Mycol & Lichenol Lab, Beijing, Peoples R China
4.Peking Univ First Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China

Recommended Citation:
Liu, X. P.,Fan, S. R.,Bai, F. Y.,et al. Antifungal susceptibility and genotypes of Candida albicans strains from patients with vulvovaginal candidiasis[J]. MYCOSES,2009,52(1):24-28.
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