北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 骨肿瘤科  > 期刊论文
学科主题: 临床医学
题名:
Wnt Signaling in Osteosarcoma
作者: Lin, Carol H.1,2,3; Ji, Tao2,3,4; Chen, Cheng-Fong2,3,5; Hoang, Bang H.2,3; Kleinerman, ES
关键词: Osteosarcoma ; Wnt ; beta-Catenin ; Dickkopf ; Wnt inhibitory protein ; Frizzled-related proteins
刊名: CURRENT ADVANCES IN OSTEOSARCOMA
发表日期: 2014
DOI: 10.1007/978-3-319-04843-7_2
卷: 804, 页:33-45
收录类别: BSCI ; SCI
文章类型: Book Chapter
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: INHIBITORY FACTOR-I ; NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; CANCER STEM-CELLS ; BETA-CATENIN ; TUMOR-GROWTH ; COLORECTAL-CANCER ; BREAST-CANCER ; COLON-CANCER ; PATHWAY ; ACTIVATION
英文摘要:

Osteosarcoma (OS) is the most common primary bone malignancy diagnosed in children and adolescents with a high propensity for local invasion and distant metastasis. Despite current multidisciplinary treatments, there has not been a drastic change in overall prognosis within the last two decades. With current treatments, 60-70 % of patients with localized disease survive. Given a propensity of Wnt signaling to control multiple cellular processes, including proliferation, cell fate determination, and differentiation, it is a critical pathway in OS disease progression. At the same time, this pathway is extremely complex with vast arrays of cross-talk. Even though decades of research have linked the role of Wnt to tumorigenesis, there are still outstanding areas that remain poorly understood and even controversial.

The canonical Wnt pathway functions to regulate the levels of the transcriptional co-activator beta-catenin, which ultimately controls key developmental gene expressions. Given the central role of this mediator, inhibition of Wnt/beta-catenin signaling has been investigated as a potential strategy for cancer control. In OS, several secreted protein families modulate the Wnt/beta-catenin signaling, including secreted Frizzled-related proteins (sFRPs), Wnt inhibitory protein (WIF), Dickkopf proteins (DKK-1,2,3), sclerostin, and small molecules. This chapter focuses on our current understanding of Wnt/beta-catenin signaling in OS, based on recent in vitro and in vivo data. Wnt activates noncanonical signaling pathways as well that are independent of beta-catenin which will be discussed. In addition, stem cells and their association with Wnt/beta-catenin are important factors to consider. Ultimately, the multiple canonical and noncanonical Wnt/beta-catenin agonists and antagonists need to be further explored for potential targeted therapies.

语种: 英语
WOS记录号: WOS:000341485500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54487
Appears in Collections:北京大学第二临床医学院_骨肿瘤科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.CHOC Childrens Hosp, Hyundai Canc Inst, Orange, CA USA
2.Univ Calif Irvine, Dept Orthopaed Surg, Irvine, CA 92868 USA
3.Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Irvine, CA 92868 USA
4.Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100871, Peoples R China
5.Taipei Vet Gen Hosp, Dept Orthopaed, Therapeut & Res Ctr Musculoskeletal Tumor, Taipei, Taiwan

Recommended Citation:
Lin, Carol H.,Ji, Tao,Chen, Cheng-Fong,et al. Wnt Signaling in Osteosarcoma[J]. CURRENT ADVANCES IN OSTEOSARCOMA,2014,804:33-45.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Lin, Carol H.]'s Articles
[Ji, Tao]'s Articles
[Chen, Cheng-Fong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Lin, Carol H.]‘s Articles
[Ji, Tao]‘s Articles
[Chen, Cheng-Fong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace