IR@PKUHSC  > 北京大学第二临床医学院  > 骨肿瘤科
学科主题临床医学
Wnt Signaling in Osteosarcoma
Lin, Carol H.1,2,3; Ji, Tao2,3,4; Chen, Cheng-Fong2,3,5; Hoang, Bang H.2,3; Kleinerman, ES
关键词Osteosarcoma Wnt Beta-catenin Dickkopf Wnt Inhibitory Protein Frizzled-related Proteins
刊名CURRENT ADVANCES IN OSTEOSARCOMA
2014
DOI10.1007/978-3-319-04843-7_2
804页:33-45
收录类别BSCI ; SCI
文章类型Book Chapter
WOS标题词Science & Technology
类目[WOS]Oncology ; Cell Biology
研究领域[WOS]Oncology ; Cell Biology
关键词[WOS]INHIBITORY FACTOR-I ; NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; CANCER STEM-CELLS ; BETA-CATENIN ; TUMOR-GROWTH ; COLORECTAL-CANCER ; BREAST-CANCER ; COLON-CANCER ; PATHWAY ; ACTIVATION
英文摘要

Osteosarcoma (OS) is the most common primary bone malignancy diagnosed in children and adolescents with a high propensity for local invasion and distant metastasis. Despite current multidisciplinary treatments, there has not been a drastic change in overall prognosis within the last two decades. With current treatments, 60-70 % of patients with localized disease survive. Given a propensity of Wnt signaling to control multiple cellular processes, including proliferation, cell fate determination, and differentiation, it is a critical pathway in OS disease progression. At the same time, this pathway is extremely complex with vast arrays of cross-talk. Even though decades of research have linked the role of Wnt to tumorigenesis, there are still outstanding areas that remain poorly understood and even controversial.

The canonical Wnt pathway functions to regulate the levels of the transcriptional co-activator beta-catenin, which ultimately controls key developmental gene expressions. Given the central role of this mediator, inhibition of Wnt/beta-catenin signaling has been investigated as a potential strategy for cancer control. In OS, several secreted protein families modulate the Wnt/beta-catenin signaling, including secreted Frizzled-related proteins (sFRPs), Wnt inhibitory protein (WIF), Dickkopf proteins (DKK-1,2,3), sclerostin, and small molecules. This chapter focuses on our current understanding of Wnt/beta-catenin signaling in OS, based on recent in vitro and in vivo data. Wnt activates noncanonical signaling pathways as well that are independent of beta-catenin which will be discussed. In addition, stem cells and their association with Wnt/beta-catenin are important factors to consider. Ultimately, the multiple canonical and noncanonical Wnt/beta-catenin agonists and antagonists need to be further explored for potential targeted therapies.

语种英语
WOS记录号WOS:000341485500003
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54487
专题北京大学第二临床医学院_骨肿瘤科
作者单位1.CHOC Childrens Hosp, Hyundai Canc Inst, Orange, CA USA
2.Univ Calif Irvine, Dept Orthopaed Surg, Irvine, CA 92868 USA
3.Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Irvine, CA 92868 USA
4.Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100871, Peoples R China
5.Taipei Vet Gen Hosp, Dept Orthopaed, Therapeut & Res Ctr Musculoskeletal Tumor, Taipei, Taiwan
推荐引用方式
GB/T 7714
Lin, Carol H.,Ji, Tao,Chen, Cheng-Fong,et al. Wnt Signaling in Osteosarcoma[J]. CURRENT ADVANCES IN OSTEOSARCOMA,2014,804:33-45.
APA Lin, Carol H.,Ji, Tao,Chen, Cheng-Fong,Hoang, Bang H.,&Kleinerman, ES.(2014).Wnt Signaling in Osteosarcoma.CURRENT ADVANCES IN OSTEOSARCOMA,804,33-45.
MLA Lin, Carol H.,et al."Wnt Signaling in Osteosarcoma".CURRENT ADVANCES IN OSTEOSARCOMA 804(2014):33-45.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lin, Carol H.]的文章
[Ji, Tao]的文章
[Chen, Cheng-Fong]的文章
百度学术
百度学术中相似的文章
[Lin, Carol H.]的文章
[Ji, Tao]的文章
[Chen, Cheng-Fong]的文章
必应学术
必应学术中相似的文章
[Lin, Carol H.]的文章
[Ji, Tao]的文章
[Chen, Cheng-Fong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录

您对该条目有什么异议,请向管理员反馈。
内 容:
Email:  *
单位:
验证码:   刷新
您在知识库使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。