IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Vaccination against hepatitis B: the Chinese experience
Zhou Yi-hua2,3; Wu Chao3; Zhuang Hui1
关键词hepatitis B virus vaccine mass immunization reduced prevalence
刊名CHINESE MEDICAL JOURNAL
2009-01-05
DOI10.3760/cma.j.issn.0366-6999.2009.01.018
122期:1页:98-102
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]VIRUS INFECTION
英文摘要

Objective To review the implementation of mass vaccination of hepatitis B vaccine and its critical role in prevention of hepatitis B virus infection in China.

Data sources The data were mainly from PubMed, China Hospital Knowledge Database, and other popular Chinese journals published from 1980 to 2008. The search term was "hepatitis B vaccine".

Study selection Original studies conducted in China and critical reviews authored by principal investigators in the field of hepatology in China were selected.

Results Chinese investigators started to develop hepatitis B vaccine in late 1970s. The first home-made plasma-derived vaccine became available in 1986, which has been completely replaced by the domestically produced recombinant (yeast or Chinese hamster ovary cell) vaccine since 2001. China health authority recommended vaccinating all infants in 1992. From then on, China has put tremendous efforts in implementation of mass vaccination. The overall coverage of hepatitis B vaccine in infants has increased steadily and reached more than 95.0% in urban and 83.0%-97.0% in rural areas. The chronic HBV carrier rate in children < 10 years of age decreased from 10.0% before the mass vaccination to 1.0%-2.0% in 2006, and that in general population decreased from 10.0% to 7.2%; overall, the nationwide mass hepatitis B vaccination has reduced more than 30 million of chronic HBV infections and HBV related severe sequlae.

Conclusion The Chinese successful experience in control of hepatitis B by mass vaccination offers an example for any unindustrialized country whoever is committed to control this disease.

语种英语
WOS记录号WOS:000262693100018
项目编号RC2007005 ; 30570063 ; 2006A A02Z453 ; 0728008
资助机构Jiangsu Province Department of Health, China ; National Natural Science Foundation of China ; 863 National High Technology Research and Development Program of China ; Natural Science Foundation of Guangxi Province
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被引频次:67[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54488
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Nanjing Univ, Sch Med, Dept Lab Med, Nanjing Drum Tower Hosp, Nanjing 210008, Peoples R China
3.Nanjing Univ, Sch Med, Dept Infect Dis, Nanjing Drum Tower Hosp, Nanjing 210008, Peoples R China
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Zhou Yi-hua,Wu Chao,Zhuang Hui. Vaccination against hepatitis B: the Chinese experience[J]. CHINESE MEDICAL JOURNAL,2009,122(1):98-102.
APA Zhou Yi-hua,Wu Chao,&Zhuang Hui.(2009).Vaccination against hepatitis B: the Chinese experience.CHINESE MEDICAL JOURNAL,122(1),98-102.
MLA Zhou Yi-hua,et al."Vaccination against hepatitis B: the Chinese experience".CHINESE MEDICAL JOURNAL 122.1(2009):98-102.
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