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DJ-1-Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells
Gao, Jian-Wei1,2; Yamane, Takuya2; Maita, Hiroshi2; Ishikawa, Shizuma3; Iguchi-Ariga, Sanae M. M.3; Pu, Xiao-Ping1; Ariga, Hiroyoshi2
关键词Dj-1 Akt Cell Death Oxidative Stress Parkinson&Prime s Disease
刊名JOURNAL OF PHARMACOLOGICAL SCIENCES
2011
DOI10.1254/jphs.10271FP
115期:1页:36-44
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]VEIN ENDOTHELIAL-CELLS ; DISEASE PROTEIN DJ-1 ; PARKINSONS-DISEASE ; ANDROGEN RECEPTOR ; MITOCHONDRIAL LOCALIZATION ; IN-VIVO ; ALPHA ; BINDING ; DEATH ; ACTIVATION
英文摘要

DJ-1 was identified as a causal gene for a familial form of early onset Parkinson′s disease (PD), park 7. DJ-1 plays roles in transcriptional regulation and the anti-oxidative stress reaction. In this study, we found that protocatechuic aldehyde (PAL), a traditional Chinese medicine compound, bound to DJ-1 in vitro and that PAL protected SH-SY5Y cells but not DJ-1-knockdown SH-SY5Y cells from oxidative stress-induced cell death, indicating that the protective effect of PAL is mediated by DJ-1. Furthermore, PAL inhibited production of reactive oxygen species and the inhibition was abated in DJ-1-knockdown cells. PAL increased and decreased phosphorylation of AKT and PTEN, respectively, in SH-SY5Y cells, suggesting that the AKT pathway is one of the specific signaling pathways in PAL-induced neuroprotection. Moreover, PAL prevented superfluous oxidation of cysteine 106 of DJ-1, an essential amino acid for DJ-1′s function. The present study demonstrates that PAL has potential neuroprotective effects through DJ-1.

语种英语
WOS记录号WOS:000286701400005
项目编号30973889
资助机构Ministry of Education, Culture, Sports, Science, and Technology ; National Institute of Biomedical Innovation (NIBIO) in Japan ; National Natural Science Foundation of China
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54489
专题北京大学药学院
作者单位1.Hokkaido Univ, Grad Sch Agr, Sapporo, Hokkaido 0608589, Japan
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
3.Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan
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Gao, Jian-Wei,Yamane, Takuya,Maita, Hiroshi,et al. DJ-1-Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2011,115(1):36-44.
APA Gao, Jian-Wei.,Yamane, Takuya.,Maita, Hiroshi.,Ishikawa, Shizuma.,Iguchi-Ariga, Sanae M. M..,...&Ariga, Hiroyoshi.(2011).DJ-1-Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells.JOURNAL OF PHARMACOLOGICAL SCIENCES,115(1),36-44.
MLA Gao, Jian-Wei,et al."DJ-1-Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells".JOURNAL OF PHARMACOLOGICAL SCIENCES 115.1(2011):36-44.
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