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学科主题: 药学
题名:
DJ-1-Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells
作者: Gao, Jian-Wei1,2; Yamane, Takuya2; Maita, Hiroshi2; Ishikawa, Shizuma3; Iguchi-Ariga, Sanae M. M.3; Pu, Xiao-Ping1; Ariga, Hiroyoshi2
关键词: DJ-1 ; AKT ; cell death ; oxidative stress ; Parkinson&prime ; s disease
刊名: JOURNAL OF PHARMACOLOGICAL SCIENCES
发表日期: 2011
DOI: 10.1254/jphs.10271FP
卷: 115, 期:1, 页:36-44
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: VEIN ENDOTHELIAL-CELLS ; DISEASE PROTEIN DJ-1 ; PARKINSONS-DISEASE ; ANDROGEN RECEPTOR ; MITOCHONDRIAL LOCALIZATION ; IN-VIVO ; ALPHA ; BINDING ; DEATH ; ACTIVATION
英文摘要:

DJ-1 was identified as a causal gene for a familial form of early onset Parkinson′s disease (PD), park 7. DJ-1 plays roles in transcriptional regulation and the anti-oxidative stress reaction. In this study, we found that protocatechuic aldehyde (PAL), a traditional Chinese medicine compound, bound to DJ-1 in vitro and that PAL protected SH-SY5Y cells but not DJ-1-knockdown SH-SY5Y cells from oxidative stress-induced cell death, indicating that the protective effect of PAL is mediated by DJ-1. Furthermore, PAL inhibited production of reactive oxygen species and the inhibition was abated in DJ-1-knockdown cells. PAL increased and decreased phosphorylation of AKT and PTEN, respectively, in SH-SY5Y cells, suggesting that the AKT pathway is one of the specific signaling pathways in PAL-induced neuroprotection. Moreover, PAL prevented superfluous oxidation of cysteine 106 of DJ-1, an essential amino acid for DJ-1′s function. The present study demonstrates that PAL has potential neuroprotective effects through DJ-1.

语种: 英语
所属项目编号: 30973889
项目资助者: Ministry of Education, Culture, Sports, Science, and Technology ; National Institute of Biomedical Innovation (NIBIO) in Japan ; National Natural Science Foundation of China
WOS记录号: WOS:000286701400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54489
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Hokkaido Univ, Grad Sch Agr, Sapporo, Hokkaido 0608589, Japan
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
3.Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

Recommended Citation:
Gao, Jian-Wei,Yamane, Takuya,Maita, Hiroshi,et al. DJ-1-Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2011,115(1):36-44.
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