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学科主题: 精神卫生
题名:
Beneficial effects of EGb761 and vitamin E on haloperidol-induced vacuous chewing movements in rats: Possible involvement of S100B mechanisms
作者: An, Hui Mei1,2; Tan, Yun Long1,2; Shi, Jing1,2; Wang, Zhi Ren1,2; Li, Jia1; Wang, Yue Chan1; Lv, Meng Han2; Zhou, Dong Feng3; Soares, Jair C.4; Kosten, Thoams R.5; De Yang, Fu1,2; Zhang, Xiang Yang1,2,4
关键词: Gingko biloba leaf extract ; Vitamin E ; Tardive dyskinesia ; S100B
刊名: BEHAVIOURAL BRAIN RESEARCH
发表日期: 2016-01-15
DOI: 10.1016/j.bbr.2015.10.004
卷: 297, 页:124-130
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: INDUCED OROFACIAL DYSKINESIA ; PLACEBO-CONTROLLED TRIAL ; TARDIVE-DYSKINESIA ; GINKGO-BILOBA ; DOUBLE-BLIND ; SCHIZOPHRENIC-PATIENTS ; OXIDATIVE STRESS ; SERUM S100B ; S-100B PROTEIN ; EXTRACT
英文摘要:

Tardive dyskinesia (TD) is a serious side effect induced by the long-term administration of typical antipsychotics. The pathophysiology of TD remains unclear, but experimental evidence suggests that neurodegeneration caused by free radicals may play an important role in TD development. S100B is considered a potential biomarker of structural neural and glial damage. This study investigated S100B expression in TD-related brain regions and assessed the effect of antioxidants Gingko biloba leaf extract (EGb761) and vitamin E (VE) on S100B in TD rats. A total of 32 rats were randomly divided into 4 study groups: saline control (saline), haloperidol alone group (Hal), EGb761-haloperidol (EGb-Hal), and vitamin E-haloperidol (VE-Hal). Rats were treated with haloperidol intraperitoneal injections (2 mg/kg/day) each day for 5 weeks. EGb761 (50 mg/kg/day) and VE (20 mg/kg/day) were then administered during a 5-week withdrawal period. We performed behavioral assessments and immunohistochemically analyzed S100B expression in four TD-related brain regions. Our findings demonstrated that haloperidol administration led to a progressive increase in VCMs and in S100B expression in all four brain regions. Both EGb761 and VE reversed these changes, and there were no group differences between the EGb761 and VE groups. Our results indicated that long-term administration of haloperidol may induce VCMs and increase S100B expression in TD-related brain regions, and S100B may be a significant biomarker related to TD pathophysiology. Moreover, the antioxidant capacity of EGb761 and VE coupled with the possible neuroprotective effects of S100B may account for their success in improving the symptoms of haloperidol-induced TD. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: JJ2014-03 ; 30770782 ; 81071086 ; 81371477 ; 7132063 ; 7072035 ; 2014000021469G218
项目资助者: Beijing Municipal TCM Science and Technology Development Program ; National Natural Science Foundation of China ; Beijing Municipal Natural Science Foundation ; Beijing Municipal Excellent Talents Foundation ; Construction Project of Institute of Integrated Traditional Chinese and Western Medicine in Beijing
WOS记录号: WOS:000367107900017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54497
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Peking Univ, Beijing HuiLongGuan Hosp, Beijing 100871, Peoples R China
3.Peking Univ, Beijing HuiLongGuan Hosp, Inst Chinese Integrat Med, Beijing 100871, Peoples R China
4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
5.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA

Recommended Citation:
An, Hui Mei,Tan, Yun Long,Shi, Jing,et al. Beneficial effects of EGb761 and vitamin E on haloperidol-induced vacuous chewing movements in rats: Possible involvement of S100B mechanisms[J]. BEHAVIOURAL BRAIN RESEARCH,2016,297:124-130.
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