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Association of norepinephrine transporter gene with methylphenidate response
Yang, L; Wang, YF; Li, J; Faraone, SV
关键词Attention-deficit/hyperactivity Disorder Methylphenidate Norepinephrine Transporter Gene
刊名JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
2004-09-01
DOI10.1097/01.chi.0000131134.63368.46
43期:9页:1154-1158
收录类别SCI ; SSCI
文章类型Article
WOS标题词Social Sciences ; Science & Technology
类目[WOS]Psychology, Developmental ; Pediatrics ; Psychiatry
研究领域[WOS]Psychology ; Pediatrics ; Psychiatry
关键词[WOS]ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; DEFICIT HYPERACTIVITY DISORDER ; MINIMAL BRAIN-DYSFUNCTION ; NORADRENALINE TRANSPORTER ; PREFRONTAL CORTEX ; D-AMPHETAMINE ; ATOMOXETINE ; EXCRETION ; DOPAMINE ; BOYS
英文摘要

Objective: This study aimed to explore the association between alleles of the norepinephrine transporter gene and the methylphenidate response. Method: Chinese Han youths with attention-deficit/hyperactivity disorder recruited in the Outpatient Department of the Institute of Mental Health from 2001 to 2004 were treated with methylphenidate in doses of 0.45 to 0.60 mg/kg per day. Behavior changes were measured by the ADHD Rating Scale-IV when optimal doses were reached. The single-nucleotide polymorphic allele of norepinephrine transporter gene G1287A was used as the genetic marker, and the genotypes were identified by restriction fragment length polymorphism analysis. Results: A significant association was found between norepinephrine transporter gene G1287A genotypes and response to methylphenidate for hyperactive-impulsive subscale scores (mean score reduction was 7.15 and 6.94 for G/G and G/A genotype, respectively, and 2.13 for A/A; p =.012) but not inattentive scores. Conclusions: These findings suggest an association between the G1287A polymorphism of the norepinephrine transporter gene and variation in methylphenidate response. Further work is needed to confirm this finding and to assess its generalization to other ethnic groups.

语种英语
WOS记录号WOS:000223467200013
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被引频次:69[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54500
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Harvard Univ, Sch Med, Dept Psychiat, Psychiat Serv, Cambridge, MA 02138 USA
3.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
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Yang, L,Wang, YF,Li, J,et al. Association of norepinephrine transporter gene with methylphenidate response[J]. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY,2004,43(9):1154-1158.
APA Yang, L,Wang, YF,Li, J,&Faraone, SV.(2004).Association of norepinephrine transporter gene with methylphenidate response.JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY,43(9),1154-1158.
MLA Yang, L,et al."Association of norepinephrine transporter gene with methylphenidate response".JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY 43.9(2004):1154-1158.
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