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(+/-)Equol inhibits invasion in prostate cancer DU145 cells possibly via down-regulation of matrix metalloproteinase-9, matrix metalloproteinase-2 and urokinase-type plasminogen activator by antioxidant activity
Zheng, Wei1; Zhang, Yumei1; Ma, Defu2; Shi, Yuhui2; Liu, Changqiu1; Wang, Peiyu2
关键词(+/-)Equol Prostate Cancer Du145 Cell Invasion Antioxidant
刊名JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
2012-07-01
DOI10.3164/jcbn.11-54
51期:1页:61-67
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]NF-E2-RELATED FACTOR-2 ; MDA-MB-453 CELLS ; JAPANESE MEN ; IN-VITRO ; BREAST ; GENISTEIN ; EQUOL ; LIGNANS ; GROWTH ; SOY
英文摘要

Exposure to soy isoflavones has been associated with low mortality of prostate cancer. In this study, we examined the effects of (+/-)equol and two representative isoflavones, daidzein and genistein, on migration and invasion in human prostate cancer DU145 cells. First of all, the three regents did not show significant growth inhibitive effect in DU145 cells until the treatments last for 72 h. Treatment with 5 mu M, 10 mu M, 50 mu M (+/-)equol, 0.5 mu M, 1 mu M, 5 mu M daidzein and genistein for 24 h decreased cell migration and invasion significantly. (+/-)equol activated phosphatase and tensin homologue deleted on chromosome ten at protein level but not mRNA level, which activated antioxidants, including superoxide dismutase and nuclear factor (erythroid-derived 2)-like 2. A reduction of malondialdehyde concentration, the product of lipid per-oxidation, was observed as well. Moreover, matrix metalloproteinase-2, matrix metalloproteinase-9, and urokinase-type plasminogen activator, the crucial members in metastasis, were down-regulated. Overall, our data indicate that (+/-)equol, daidzein and genistein may have significant anti-invasion effect in DU145 cells (in vitro). The effects induced by (+/-)equol may relate to its anti-oxidant effect mediated by phosphatase and tensin homologue deleted on chromosome ten.

语种英语
WOS记录号WOS:000306387800011
项目编号30471449 ; 30671759 ; 30872114 ; 30872115
资助机构National Natural Science Foundation, PR China
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54501
专题北京大学公共卫生学院
北京大学药学院_药剂学系
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Social Med & Hlth Educ, Sch Publ Hlth, Beijing 100191, Peoples R China
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GB/T 7714
Zheng, Wei,Zhang, Yumei,Ma, Defu,et al. (+/-)Equol inhibits invasion in prostate cancer DU145 cells possibly via down-regulation of matrix metalloproteinase-9, matrix metalloproteinase-2 and urokinase-type plasminogen activator by antioxidant activity[J]. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,2012,51(1):61-67.
APA Zheng, Wei,Zhang, Yumei,Ma, Defu,Shi, Yuhui,Liu, Changqiu,&Wang, Peiyu.(2012).(+/-)Equol inhibits invasion in prostate cancer DU145 cells possibly via down-regulation of matrix metalloproteinase-9, matrix metalloproteinase-2 and urokinase-type plasminogen activator by antioxidant activity.JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,51(1),61-67.
MLA Zheng, Wei,et al."(+/-)Equol inhibits invasion in prostate cancer DU145 cells possibly via down-regulation of matrix metalloproteinase-9, matrix metalloproteinase-2 and urokinase-type plasminogen activator by antioxidant activity".JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 51.1(2012):61-67.
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