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学科主题: 公共卫生
题名:
(+/-)Equol inhibits invasion in prostate cancer DU145 cells possibly via down-regulation of matrix metalloproteinase-9, matrix metalloproteinase-2 and urokinase-type plasminogen activator by antioxidant activity
作者: Zheng, Wei1; Zhang, Yumei1; Ma, Defu2; Shi, Yuhui2; Liu, Changqiu1; Wang, Peiyu2
关键词: (+/-)equol ; prostate cancer ; DU145 cell ; invasion ; antioxidant
刊名: JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
发表日期: 2012-07-01
DOI: 10.3164/jcbn.11-54
卷: 51, 期:1, 页:61-67
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: NF-E2-RELATED FACTOR-2 ; MDA-MB-453 CELLS ; JAPANESE MEN ; IN-VITRO ; BREAST ; GENISTEIN ; EQUOL ; LIGNANS ; GROWTH ; SOY
英文摘要:

Exposure to soy isoflavones has been associated with low mortality of prostate cancer. In this study, we examined the effects of (+/-)equol and two representative isoflavones, daidzein and genistein, on migration and invasion in human prostate cancer DU145 cells. First of all, the three regents did not show significant growth inhibitive effect in DU145 cells until the treatments last for 72 h. Treatment with 5 mu M, 10 mu M, 50 mu M (+/-)equol, 0.5 mu M, 1 mu M, 5 mu M daidzein and genistein for 24 h decreased cell migration and invasion significantly. (+/-)equol activated phosphatase and tensin homologue deleted on chromosome ten at protein level but not mRNA level, which activated antioxidants, including superoxide dismutase and nuclear factor (erythroid-derived 2)-like 2. A reduction of malondialdehyde concentration, the product of lipid per-oxidation, was observed as well. Moreover, matrix metalloproteinase-2, matrix metalloproteinase-9, and urokinase-type plasminogen activator, the crucial members in metastasis, were down-regulated. Overall, our data indicate that (+/-)equol, daidzein and genistein may have significant anti-invasion effect in DU145 cells (in vitro). The effects induced by (+/-)equol may relate to its anti-oxidant effect mediated by phosphatase and tensin homologue deleted on chromosome ten.

语种: 英语
所属项目编号: 30471449 ; 30671759 ; 30872114 ; 30872115
项目资助者: National Natural Science Foundation, PR China
WOS记录号: WOS:000306387800011
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54501
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Social Med & Hlth Educ, Sch Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Zheng, Wei,Zhang, Yumei,Ma, Defu,et al. (+/-)Equol inhibits invasion in prostate cancer DU145 cells possibly via down-regulation of matrix metalloproteinase-9, matrix metalloproteinase-2 and urokinase-type plasminogen activator by antioxidant activity[J]. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,2012,51(1):61-67.
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