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IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科  > 期刊论文
学科主题: 临床医学
题名:
Trends in the prevalence of invasive fungal infections from an analysis of annual records of autopsy cases of Toho University
作者: Shimodaira, Kayoko2; Okubo, Yoichiro; Nakayama, Haruo; Wakayama, Megumi1; Shinozaki, Minoru; Ishiwatari, Takao; Sasai, Daisuke; Nemoto, Tetsuo; Takahashi, Kei3; Ishii, Toshiharu4; Saji, Tsutomu2; Shibuya, Kazutoshi5
关键词: Invasive fungal infection ; prevalence ; trends ; autopsy ; epidemiology
刊名: MYCOSES
发表日期: 2012-09-01
DOI: 10.1111/j.1439-0507.2012.02169.x
卷: 55, 期:5, 页:435-443
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology ; Mycology
研究领域[WOS]: Dermatology ; Mycology
关键词[WOS]: STATISTICAL-SURVEY ; JAPAN ; EPIDEMIOLOGY ; MYCOSES ; HISTORY ; DISEASE ; CANCER
英文摘要:

Clinical diagnosis of invasive fungal infections (IFIs) is sometimes difficult, and obtaining an accurate assessment of trends concerning the prevalence of IFIs is a challenge. The aim of this study was to determine trends in the prevalence of IFIs from an autopsy survey. The retrospective review of autopsy records stored in Toho University was performed on all documented cases with fungal infection from 1955 to 2006. A total of 411 cases of IFIs were detected among 10 297 autopsies. The prevalence of candidiasis decreased from 3.6% (198193) to 2.0% (19942006), and that of aspergillosis increased throughout the 52-year period and reached 2.0% (19942006). The prevalence of IFIs in the patient group comprising haematological disorders was significantly higher (19.9%) than in other patient groups (2.9%), of which the odds ratio was 18.4 for mucormycosis and 10.0 for aspergillosis. The lung was the most common organ involved irrespective of major fungal species, and most cases with candidiasis showed multiple-organ infection. Results confirmed the increasing prevalence of aspergillosis and high risk of IFIs in the patient group with haematological disorders. IFIs were also detected in an immunocompromised state caused not only by primary disease but also by treatment with anti-tumour drugs and corticosteroids.

语种: 英语
所属项目编号: H22-Shinko-Ippan-008 ; H23-Shinko-Ippan-018 ; H20-nannchi-ippann-35 ; 23-19 ; 23-21 ; 23-28
项目资助者: Health Science Research Grants for Research on Emerging and Reemerging Infectious Diseases ; Ministry of Health, Labor and Welfare of Japan ; Strategic Basis on Research Grounds for Nongovernmental Schools at Heisei 20th from the Ministry of Education, Culture, Sports, Science and Technology of Japan ; Strategic Research Foundation ; Ministry of Education, Culture, Sports, Science and Technology of Japan ; Toho University
WOS记录号: WOS:000307543300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54515
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Toho Univ, Sch Med, Dept Surg Pathol, Ota Ku, Tokyo 1438541, Japan
2.Toho Univ, Omori Med Ctr, Dept Pediat, Tokyo 1438541, Japan
3.Toho Univ, Ohashi Med Ctr, Dept Pathol, Tokyo 1438541, Japan
4.Toho Univ, Sch Med, Dept Pathol, Tokyo 1438541, Japan
5.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100871, Peoples R China

Recommended Citation:
Shimodaira, Kayoko,Okubo, Yoichiro,Nakayama, Haruo,et al. Trends in the prevalence of invasive fungal infections from an analysis of annual records of autopsy cases of Toho University[J]. MYCOSES,2012,55(5):435-443.
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