北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Functional alpha(1)-adrenergic receptor subtypes in human right gastroepiploic artery
作者: Han, JL; Zhang, YY; Lu, ZZ; Mao, JM; Chen, MZ; Han, QD
关键词: alpha-1 adrenergic receptors ; right gastroepiploic artery ; vasoconstriction ; adrenergic alpha-antagonists ; RS17053 ; 5-MU ; BMY7378 ; WB4101 ; chlorethylclonidine
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2003-04-01
卷: 24, 期:4, 页:327-331
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: BYPASS GRAFT
英文摘要:

AIM: To study the functional alpha(1)-adrenergic receptor (alpha(1)-AR) subtypes in human right gastroepiploic artery (RGA). METHODS: The effects Of alpha(2)-AR, alpha(1)-AR, and alpha(1)-AR subtype selective antagonists on norepinephrine (NE)induced vasoconstriction in isolated human RGA were observed by contractile function experiment. RESULTS: Cumulative concentration-response curves for NE were competitively antagonized in RGA by alpha(2)-AR selective antagonist yohimbine (pA(2) 6.82 +/- 0.28, slope 1.12 +/- 0.40), alpha(1)-AR selective antagonist prazosin (pA(2) 9.77 +/- 0.22, slope 0.90 +/- 0.22), alpha(1A)-AR selective antagonists RS17053 (pA(2) 8.42 +/- 0.20, slope 0.93 +/- 0.20) and 5-MU (pA(2) 8.42 +/- 0.22, slope 0.88 +/- 0.18), alpha(1D)-AR selective antagonist BMY7378 (pA(2) 6.84 +/- 0.32, slope 1.05 +/- 0.17), and alpha(1A)-, alpha(1B)-AR selective antagonist WB4101 (pA(2) 8.88 +/- 0.20, slope 1.15 +/- 0.16). The correlation coefficients between these pA2 values of alpha(1)-AR selective antagonists with pK(i) values of which obtained from alpha(1A)-, alpha(1B)- and alpha(1D)-AR cloned cells are 0.95, 0.82, and 0.42. After the vessels were pretreated by chlorethylclonidine (CEC), an alpha(1B)- and alpha(1D)-AR irreversible alkylating agent, the pD(2) values were changed from 5.9 +/- 0.5 to 5.6 +/- 0.6 and the maximal contraction was changed from (8.9 +/- 3.2) g to (8.0 +/- 3.2) g, respectively. The difference was not significant. CONCLUSION: In human RGA, the contraction response is mainly mediated by alpha(1)-AR, of which alpha(1A)-AR plays an important role, whereas alpha(1B)- and alpha(1D)-AR are not involved in the contraction response.

语种: 英语
WOS记录号: WOS:000182030200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54535
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Dept Cardiovasol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China

Recommended Citation:
Han, JL,Zhang, YY,Lu, ZZ,et al. Functional alpha(1)-adrenergic receptor subtypes in human right gastroepiploic artery[J]. ACTA PHARMACOLOGICA SINICA,2003,24(4):327-331.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Han, JL]'s Articles
[Zhang, YY]'s Articles
[Lu, ZZ]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Han, JL]‘s Articles
[Zhang, YY]‘s Articles
[Lu, ZZ]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace