IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Functional alpha(1)-adrenergic receptor subtypes in human right gastroepiploic artery
Han, JL; Zhang, YY; Lu, ZZ; Mao, JM; Chen, MZ; Han, QD
关键词Alpha-1 Adrenergic Receptors Right Gastroepiploic Artery Vasoconstriction Adrenergic Alpha-antagonists Rs17053 5-mu Bmy7378 Wb4101 Chlorethylclonidine
刊名ACTA PHARMACOLOGICA SINICA
2003-04-01
24期:4页:327-331
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]BYPASS GRAFT
英文摘要

AIM: To study the functional alpha(1)-adrenergic receptor (alpha(1)-AR) subtypes in human right gastroepiploic artery (RGA). METHODS: The effects Of alpha(2)-AR, alpha(1)-AR, and alpha(1)-AR subtype selective antagonists on norepinephrine (NE)induced vasoconstriction in isolated human RGA were observed by contractile function experiment. RESULTS: Cumulative concentration-response curves for NE were competitively antagonized in RGA by alpha(2)-AR selective antagonist yohimbine (pA(2) 6.82 +/- 0.28, slope 1.12 +/- 0.40), alpha(1)-AR selective antagonist prazosin (pA(2) 9.77 +/- 0.22, slope 0.90 +/- 0.22), alpha(1A)-AR selective antagonists RS17053 (pA(2) 8.42 +/- 0.20, slope 0.93 +/- 0.20) and 5-MU (pA(2) 8.42 +/- 0.22, slope 0.88 +/- 0.18), alpha(1D)-AR selective antagonist BMY7378 (pA(2) 6.84 +/- 0.32, slope 1.05 +/- 0.17), and alpha(1A)-, alpha(1B)-AR selective antagonist WB4101 (pA(2) 8.88 +/- 0.20, slope 1.15 +/- 0.16). The correlation coefficients between these pA2 values of alpha(1)-AR selective antagonists with pK(i) values of which obtained from alpha(1A)-, alpha(1B)- and alpha(1D)-AR cloned cells are 0.95, 0.82, and 0.42. After the vessels were pretreated by chlorethylclonidine (CEC), an alpha(1B)- and alpha(1D)-AR irreversible alkylating agent, the pD(2) values were changed from 5.9 +/- 0.5 to 5.6 +/- 0.6 and the maximal contraction was changed from (8.9 +/- 3.2) g to (8.0 +/- 3.2) g, respectively. The difference was not significant. CONCLUSION: In human RGA, the contraction response is mainly mediated by alpha(1)-AR, of which alpha(1A)-AR plays an important role, whereas alpha(1B)- and alpha(1D)-AR are not involved in the contraction response.

语种英语
WOS记录号WOS:000182030200008
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54535
专题北京大学第三临床医学院
作者单位1.Peking Univ, Hosp 3, Dept Cardiovasol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Han, JL,Zhang, YY,Lu, ZZ,et al. Functional alpha(1)-adrenergic receptor subtypes in human right gastroepiploic artery[J]. ACTA PHARMACOLOGICA SINICA,2003,24(4):327-331.
APA Han, JL,Zhang, YY,Lu, ZZ,Mao, JM,Chen, MZ,&Han, QD.(2003).Functional alpha(1)-adrenergic receptor subtypes in human right gastroepiploic artery.ACTA PHARMACOLOGICA SINICA,24(4),327-331.
MLA Han, JL,et al."Functional alpha(1)-adrenergic receptor subtypes in human right gastroepiploic artery".ACTA PHARMACOLOGICA SINICA 24.4(2003):327-331.
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