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Adenovirus-delivered PDCD5 counteracts adriamycin resistance of osteosarcoma cells through enhancing apoptosis and inhibiting Pgp
Zhao, Hui1; Peng, Changliang2; Ruan, Guorui3,4; Zhou, Junlin1; Li, Yihan1; Hai, Yong1
关键词Osteosarcoma Mdr Pdcd5 Apoptosis
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2014
7期:12页:5429-5436
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]MEDIATED MULTIDRUG-RESISTANCE ; GENE-EXPRESSION PROFILES ; HIGH-DOSE METHOTREXATE ; P-GLYCOPROTEIN ; OSTEOGENIC-SARCOMA ; DRUG-RESISTANCE ; TUMOR-CELLS ; PREOPERATIVE CHEMOTHERAPY ; CANCER-CELLS ; LUNG-CANCER
英文摘要

In the present study, we investigated the roles of PDCD5 (programmed cell death 5) in multidrug resistance (MDR) of osteosarcoma cells and the possible lurking mechanisms. An adenovirus expression vector of PDCD5 was constructed and transfected into human adriamycin-resistant osteosarcoma cell line Saos-2/ADM. We found that up-regulation of PDCD5 could significantly enhance the sensitivity of Saos-2/ADM cells towards vincristine, methotrexate, cisplatin and arsenic trioxide (As2O3), and could decrease the capacity of cells to efflux adriamycin. PDCD5 could significantly down regulate the expression of P-glycoprotein (Pgp), but not affect the expression of multidrug resistance associated protein (MRP) or the glutathione S-transferase (GST). PDCD5 was also able to significantly increase the apoptotic activity of modified osteosarcoma cells. Further study of the biological functions of PDCD5 might be helpful in the understanding of the mechanisms of multidrug resistance (MDR) in osteosarcoma and exploring PDCD5 based adjuvant genetic therapy.

语种英语
WOS记录号WOS:000348303600095
项目编号81202124 ; 81301727
资助机构National Natural Science Foundation of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54536
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Peking Univ, Inst Hematol, Beijing 100871, Peoples R China
3.Capital Med Univ, Beijing Chaoyang Hosp, Dept Orthoped, Beijing, Peoples R China
4.Shandong Univ, Affiliated Hosp 2, Dept Orthoped, Jinan 250100, Peoples R China
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Zhao, Hui,Peng, Changliang,Ruan, Guorui,et al. Adenovirus-delivered PDCD5 counteracts adriamycin resistance of osteosarcoma cells through enhancing apoptosis and inhibiting Pgp[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2014,7(12):5429-5436.
APA Zhao, Hui,Peng, Changliang,Ruan, Guorui,Zhou, Junlin,Li, Yihan,&Hai, Yong.(2014).Adenovirus-delivered PDCD5 counteracts adriamycin resistance of osteosarcoma cells through enhancing apoptosis and inhibiting Pgp.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,7(12),5429-5436.
MLA Zhao, Hui,et al."Adenovirus-delivered PDCD5 counteracts adriamycin resistance of osteosarcoma cells through enhancing apoptosis and inhibiting Pgp".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 7.12(2014):5429-5436.
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