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学科主题: 临床医学
题名:
Adenovirus-delivered PDCD5 counteracts adriamycin resistance of osteosarcoma cells through enhancing apoptosis and inhibiting Pgp
作者: Zhao, Hui1; Peng, Changliang2; Ruan, Guorui3,4; Zhou, Junlin1; Li, Yihan1; Hai, Yong1
关键词: Osteosarcoma ; MDR ; PDCD5 ; apoptosis
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2014
卷: 7, 期:12, 页:5429-5436
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: MEDIATED MULTIDRUG-RESISTANCE ; GENE-EXPRESSION PROFILES ; HIGH-DOSE METHOTREXATE ; P-GLYCOPROTEIN ; OSTEOGENIC-SARCOMA ; DRUG-RESISTANCE ; TUMOR-CELLS ; PREOPERATIVE CHEMOTHERAPY ; CANCER-CELLS ; LUNG-CANCER
英文摘要:

In the present study, we investigated the roles of PDCD5 (programmed cell death 5) in multidrug resistance (MDR) of osteosarcoma cells and the possible lurking mechanisms. An adenovirus expression vector of PDCD5 was constructed and transfected into human adriamycin-resistant osteosarcoma cell line Saos-2/ADM. We found that up-regulation of PDCD5 could significantly enhance the sensitivity of Saos-2/ADM cells towards vincristine, methotrexate, cisplatin and arsenic trioxide (As2O3), and could decrease the capacity of cells to efflux adriamycin. PDCD5 could significantly down regulate the expression of P-glycoprotein (Pgp), but not affect the expression of multidrug resistance associated protein (MRP) or the glutathione S-transferase (GST). PDCD5 was also able to significantly increase the apoptotic activity of modified osteosarcoma cells. Further study of the biological functions of PDCD5 might be helpful in the understanding of the mechanisms of multidrug resistance (MDR) in osteosarcoma and exploring PDCD5 based adjuvant genetic therapy.

语种: 英语
所属项目编号: 81202124 ; 81301727
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000348303600095
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54536
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Peking Univ, Inst Hematol, Beijing 100871, Peoples R China
3.Capital Med Univ, Beijing Chaoyang Hosp, Dept Orthoped, Beijing, Peoples R China
4.Shandong Univ, Affiliated Hosp 2, Dept Orthoped, Jinan 250100, Peoples R China

Recommended Citation:
Zhao, Hui,Peng, Changliang,Ruan, Guorui,et al. Adenovirus-delivered PDCD5 counteracts adriamycin resistance of osteosarcoma cells through enhancing apoptosis and inhibiting Pgp[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2014,7(12):5429-5436.
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