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学科主题: 临床医学
题名:
Thirteen to twenty-seven-year follow-up of patients with hepatitis C while transfusing or donating plasma
作者: Rao, Hui-ying; Wei, Lai; Zhao, Jing-min; Sun, De-gui
关键词: hepatitis C ; histology ; follow-up studies ; ultrasonography
刊名: HEPATO-GASTROENTEROLOGY
发表日期: 2007-04-01
卷: 54, 期:75, 页:826-829
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Surgery
研究领域[WOS]: Gastroenterology & Hepatology ; Surgery
关键词[WOS]: NATURAL-HISTORY
英文摘要:

Background/Aims: Heaptitis C virus is a hepatotrophic flavivirus infecting 170 million people worldwide and 3.2% people in China. We aim to investigate the clinical outcomes and hepatic histology of patients with hepatitis C in the north of China.

Methodology: Nine patients with hepatitis C, 4 males and 5 females, aged 44 +/- 7 years old, who were infected during transfusion or blood donation underwent follow-up for 13-27 years. We performed liver histological examination by biopsy, ultrasonography, and biochemical examination of alanine transaminase (ALT), aspartate transaminase, and total bilirubin. The serum anti-HCV was detected by ELISA, and HCV RNA quantification by PCR.

Results: ALT were,higher than the normal value at every time point and HCV RNA remained positive (3.5x10(6) copies/mL) in all patients. Ultra sonography showed mild and moderated hepatitis (3 and 6 cases respectively). The modified histological activity indices (HAI) were 5.0-8.5 and fibrosis scores were 1-4. The ALT value was higher in the moderate cases than in the mild cases, and higher in those with higher HAI. The viral load was higher in the patients infected by the virus of the genotype 2.

Conclusions: The clinical outcomes and hepatic histology of patients with hepatitis C in north of China seem not very severe.

语种: 英语
WOS记录号: WOS:000247037500042
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54540
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.302 Hosp PLA, Beijing, Peoples R China
2.Guan Cty Sanitary & Antiepidem Stn, Hebei Guan, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China

Recommended Citation:
Rao, Hui-ying,Wei, Lai,Zhao, Jing-min,et al. Thirteen to twenty-seven-year follow-up of patients with hepatitis C while transfusing or donating plasma[J]. HEPATO-GASTROENTEROLOGY,2007,54(75):826-829.
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