学科主题临床医学
Thirteen to twenty-seven-year follow-up of patients with hepatitis C while transfusing or donating plasma
Rao, Hui-ying; Wei, Lai; Zhao, Jing-min; Sun, De-gui
关键词Hepatitis c Histology Follow-up Studies Ultrasonography
刊名HEPATO-GASTROENTEROLOGY
2007-04-01
54期:75页:826-829
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]NATURAL-HISTORY
英文摘要

Background/Aims: Heaptitis C virus is a hepatotrophic flavivirus infecting 170 million people worldwide and 3.2% people in China. We aim to investigate the clinical outcomes and hepatic histology of patients with hepatitis C in the north of China.

Methodology: Nine patients with hepatitis C, 4 males and 5 females, aged 44 +/- 7 years old, who were infected during transfusion or blood donation underwent follow-up for 13-27 years. We performed liver histological examination by biopsy, ultrasonography, and biochemical examination of alanine transaminase (ALT), aspartate transaminase, and total bilirubin. The serum anti-HCV was detected by ELISA, and HCV RNA quantification by PCR.

Results: ALT were,higher than the normal value at every time point and HCV RNA remained positive (3.5x10(6) copies/mL) in all patients. Ultra sonography showed mild and moderated hepatitis (3 and 6 cases respectively). The modified histological activity indices (HAI) were 5.0-8.5 and fibrosis scores were 1-4. The ALT value was higher in the moderate cases than in the mild cases, and higher in those with higher HAI. The viral load was higher in the patients infected by the virus of the genotype 2.

Conclusions: The clinical outcomes and hepatic histology of patients with hepatitis C in north of China seem not very severe.

语种英语
WOS记录号WOS:000247037500042
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54540
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.302 Hosp PLA, Beijing, Peoples R China
2.Guan Cty Sanitary & Antiepidem Stn, Hebei Guan, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Rao, Hui-ying,Wei, Lai,Zhao, Jing-min,et al. Thirteen to twenty-seven-year follow-up of patients with hepatitis C while transfusing or donating plasma[J]. HEPATO-GASTROENTEROLOGY,2007,54(75):826-829.
APA Rao, Hui-ying,Wei, Lai,Zhao, Jing-min,&Sun, De-gui.(2007).Thirteen to twenty-seven-year follow-up of patients with hepatitis C while transfusing or donating plasma.HEPATO-GASTROENTEROLOGY,54(75),826-829.
MLA Rao, Hui-ying,et al."Thirteen to twenty-seven-year follow-up of patients with hepatitis C while transfusing or donating plasma".HEPATO-GASTROENTEROLOGY 54.75(2007):826-829.
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