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学科主题临床医学
Relative contribution of various airway protective mechanisms to prevention of aspiration during swallowing
Medda, BK; Kern, M; Ren, JL; Xie, PY; Ulualp, SO; Lang, IM; Shaker, R
关键词Suprahyoid Muscles Vocal Cord Epiglottis Larynx
刊名AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
2003-06-01
DOI10.1152/ajpgi.00395.2002
284期:6页:G933-G939
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Physiology
研究领域[WOS]Gastroenterology & Hepatology ; Physiology
关键词[WOS]UPPER ESOPHAGEAL SPHINCTER ; PHARYNGEAL BOLUS TRANSIT ; ZENKERS DIVERTICULUM ; COORDINATION ; PARALYSIS ; SURGERY ; CLOSURE ; PHASES
英文摘要

Deglutitive airway protective mechanisms include glottal closure, epiglottal descent, and anterosuperior displacement of the larynx. Aspiration of swallowed material may occur during the pre-, intra-, or postpharyngeal phase of swallowing. Our objectives were to determine the relative contribution of the airway protective mechanisms during each phase of swallow in 14 decerebrated cats before and after suprahyoid myotomy, epiglottectomy, and unilateral cordectomy. After myotomy, superior excursions of the hyoid, thyroid, and cricoid cartilages and anteroposterior diameter of maximum upper esophageal spincter (UES) opening were significantly diminished, but the incidence of pharyngeal residue significantly increased ( P < 0.05). No aspiration was observed in the predeglutitive period. After myotomy, the incidence of aspiration significantly increased in both intra- and postdeglutitive periods. Epiglottectomy did not alter aspiration incidence, but unilateral cordectomy resulted in a 100% incidence of intra- and postdeglutitive aspiration. In conclusion, glottal closure constitutes the primary mechanism for prevention of intra- and postdeglutitive aspiration, but laryngeal elevation may assist this function. Bolus pulsion without laryngeal distraction can open the UES, but at risk of aspiration due to decreased pharyngeal clearance. The epiglottis provides no apparent airway protection during any phase of swallowing.

语种英语
WOS记录号WOS:000182699700009
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54547
专题北京大学第一临床医学院_消化科
作者单位1.Med Coll Wisconsin, Dept Radiol, Milwaukee, WI 53226 USA
2.Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA
3.Med Coll Wisconsin, Froedtert Mem Lutheran Hosp, Div Gastroenterol & Hepatol, Dysphagia Inst, Milwaukee, WI 53226 USA
4.Med Coll Wisconsin, Dept Otolaryngol & Human Commun, Milwaukee, WI 53226 USA
5.Peking Univ, Dept Gastroenterol, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Medda, BK,Kern, M,Ren, JL,et al. Relative contribution of various airway protective mechanisms to prevention of aspiration during swallowing[J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY,2003,284(6):G933-G939.
APA Medda, BK.,Kern, M.,Ren, JL.,Xie, PY.,Ulualp, SO.,...&Shaker, R.(2003).Relative contribution of various airway protective mechanisms to prevention of aspiration during swallowing.AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY,284(6),G933-G939.
MLA Medda, BK,et al."Relative contribution of various airway protective mechanisms to prevention of aspiration during swallowing".AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 284.6(2003):G933-G939.
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