IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Reactive lymphoid hyperplasia of the liver mimicking hepatocellular carcinoma: incidental finding of two cases
Lv, Ang1; Liu, Wendy2; Qian, Hong-Gang1; Leng, Jia-Hua1; Hao, Chun-Yi1
关键词Reactive Lymphoid Hyperplasia Liver Hepatocellular Carcinoma
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2015
8期:5页:5863-5869
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pathology
研究领域[WOS]Oncology ; Pathology
关键词[WOS]OF-THE-LITERATURE ; HEPATIC PSEUDOLYMPHOMA ; PATIENT
英文摘要

Reactive lymphoid hyperplasia is a rare disease that forms a mass-like lesion and is characterized by the proliferation of non-neoplastic, polyclonal lymphocytes forming follicles. We recently encountered 2 cases of reactive lymphoid hyperplasia of liver, both of which were asymptomatic and mimicked hepatocellular carcinoma by various imaging modalities. Based on the clinical impression of hepatocellular carcinoma, surgical resections were performed. Microscopic findings revealed that both lesions consisted of an aggregation of lymphocytes consisting of predominantly B-cells, with multiple lymphoid follicles positive for CD10 and negative for bcl-2, consistent with the diagnosis of reactive lymphoid hyperplasia. Polyclonality of both lesions was further confirmed by B cell receptor gene rearrangement study. The incidence of reactive lymphoid hyperplasia in the liver is exceedingly rare, and it is difficult to differentiate such lesions from hepatic malignancies based upon clinical grounds. The clinicopathological findings and literature review of this report may be helpful to improve the clinical decision-making.

语种英语
WOS记录号WOS:000358370300191
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54548
Collection北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Hepatopancreato Biliary Surg, Beijing 100871, Peoples R China
2.Univ Hosp Case Med Ctr, Dept Pathol, Cleveland, OH 44106 USA
Recommended Citation
GB/T 7714
Lv, Ang,Liu, Wendy,Qian, Hong-Gang,et al. Reactive lymphoid hyperplasia of the liver mimicking hepatocellular carcinoma: incidental finding of two cases[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2015,8(5):5863-5869.
APA Lv, Ang,Liu, Wendy,Qian, Hong-Gang,Leng, Jia-Hua,&Hao, Chun-Yi.(2015).Reactive lymphoid hyperplasia of the liver mimicking hepatocellular carcinoma: incidental finding of two cases.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,8(5),5863-5869.
MLA Lv, Ang,et al."Reactive lymphoid hyperplasia of the liver mimicking hepatocellular carcinoma: incidental finding of two cases".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8.5(2015):5863-5869.
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