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学科主题: 临床医学
题名:
Chemokine receptor 5 (CCR5) delta 32 polymorphism in lupus nephritis: A large case-control study and meta-analysis
作者: Cheng, Fa-Juan1,2,3; Zhou, Xu-Jie1,2,3; Zhao, Yan-Feng1,2,3; Zhao, Ming-Hui1,2,3; Zhang, Hong1,2,3
关键词: Chinese Han ethnicity ; complex autoimmune disease ; functional genetic variant ; susceptibility ; systemic lupus erythematosus
刊名: AUTOIMMUNITY
发表日期: 2014-09-01
DOI: 10.3109/08916934.2014.906581
卷: 47, 期:6, 页:383-388
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: GENOME-WIDE ASSOCIATION ; CHINESE HAN POPULATION ; C-REACTIVE PROTEIN ; DISEASE SUSCEPTIBILITY ; RHEUMATOID-ARTHRITIS ; BRAZILIAN POPULATION ; INTERSTITIAL LESIONS ; FUNCTIONAL VARIANT ; MURINE LUPUS ; ERYTHEMATOSUS
英文摘要:

Objectives: Recent animal experiments showed that CCR5-deficient lupus mice (CCR5(-/-)) were closely associated with aggravated lupus nephritis. CCR5 Delta 32 variation, a nonsynonymous mutation of CCR5, resulted in altered CCR5 function. However, the CCR5 Delta 32 mutation in human lupus nephritis has been rarely reported in the literature. Methods: A large case-control study that included 2010 samples from a Chinese population was conducted, followed by a meta-analysis combining the current and previously published studies to explore the effect of CCR5 Delta 32 on lupus nephritis susceptibility. Results: Four CCR5 Delta 32 heterozygote carriers were detected in lupus nephritis patients only. We detected no CCR5 Delta 32 homozygotes in our study population. In the meta-analysis, including 1,092 cases and 2,229 controls, we found great heterogeneity between studies (p < 0.001, I-2 = 89.6%). Furthermore, stratified and sensitivity analyses suggested that ethnicity and CCR5 Delta 32 allele frequency were the main origin of heterogeneity. In the subgroups without obvious heterogeneity, we observed a positive correlation between CCR5 Delta 32 and lupus nephritis risk (p < 0.05). Conclusions: Our study confirmed that the CCR5 Delta 32 mutation is a very rare variation found in the Chinese population with Han ethnicity. However, CCR5 Delta 32 might play a role in lupus nephritis susceptibility. Future replications and functional studies are needed.

语种: 英语
所属项目编号: 2012CB517700 ; 81200524 ; 20120001120008 ; 20121000110 ; 81321064
项目资助者: Major State Basic Research Development Program of China (973 program) ; National Natural Science Foundation of China ; Foundation of Ministry of Education of China ; Research Fund of Beijing Municipal Science and Technology ; Natural Science Fund of China
WOS记录号: WOS:000340886100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54550
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Div Renal, Dept Med, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
3.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China

Recommended Citation:
Cheng, Fa-Juan,Zhou, Xu-Jie,Zhao, Yan-Feng,et al. Chemokine receptor 5 (CCR5) delta 32 polymorphism in lupus nephritis: A large case-control study and meta-analysis[J]. AUTOIMMUNITY,2014,47(6):383-388.
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