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学科主题: 基础医学
题名:
COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT FACILITATES THE NEURITE OUTGROWTH IN CORTICAL NEURONS AFTER OXYGEN AND GLUCOSE DEPRIVATION THROUGH PTN-DEPENDENT PATHWAY
作者: Wang, Y.1,2; Qiu, B.1; Liu, J.1; Zhu, Wei-Guo2; Zhu, S.1
关键词: CART ; OGD ; PTN ; cortical neuron ; neurite outgrowth
刊名: NEUROSCIENCE
发表日期: 2014-09-26
DOI: 10.1016/j.neuroscience.2014.06.064
卷: 277, 页:103-110
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: GROWTH-ASSOCIATED MOLECULE ; MESSENGER-RNA ; CEREBRAL-ISCHEMIA ; REACTIVE ASTROCYTES ; FUNCTIONAL RECOVERY ; NEUROTROPHIC FACTOR ; PROTECTS BRAIN ; UP-REGULATION ; IN-VITRO ; PLEIOTROPHIN
英文摘要:

Cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide that plays neuroprotective roles in cerebral ischemia and reperfusion (I/R) injury in animal models or oxygen and glucose deprivation (OGD) in cultured neurons. Recent data suggest that intranasal CART treatment facilitates neuroregeneration in stroke brain. However, little is known about the effects of post-treatment with CART during the neuronal recovery after OGD and reoxygenation in cultured primary cortical neurons. The present study was to investigate the role of CART treated after OGD injury in neurons. Primary mouse cortical neurons were subjected to OGD and then treated with CART. Our data show that post-treatment with CART reduced the neuronal apoptosis caused by OGD injury. In addition, CART repaired OGDimpaired cortical neurons by increasing the expression of growth-associated protein 43 (GAP43), which promotes neurite outgrowth. This effect depends on pleiotrophin (PTN) as siRNA- mediated PTN knockdown totally abolished the increase in CART-stimulated GAP43 protein levels. In summary, our findings demonstrate that CART repairs the neuronal injury after OGD by facilitating neurite outgrowth through PTN-dependent pathway. The role for CART in neurite outgrowth makes it a new potential therapeutic agent for the treatment of neurodegenerative diseases. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81171081 ; 2014CB542200
项目资助者: National Natural Science Foundation of China ; National Basic Research Program of China
WOS记录号: WOS:000341488700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54552
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Y.,Qiu, B.,Liu, J.,et al. COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT FACILITATES THE NEURITE OUTGROWTH IN CORTICAL NEURONS AFTER OXYGEN AND GLUCOSE DEPRIVATION THROUGH PTN-DEPENDENT PATHWAY[J]. NEUROSCIENCE,2014,277:103-110.
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