IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT FACILITATES THE NEURITE OUTGROWTH IN CORTICAL NEURONS AFTER OXYGEN AND GLUCOSE DEPRIVATION THROUGH PTN-DEPENDENT PATHWAY
Wang, Y.1,2; Qiu, B.1; Liu, J.1; Zhu, Wei-Guo2; Zhu, S.1
关键词Cart Ogd Ptn Cortical Neuron Neurite Outgrowth
刊名NEUROSCIENCE
2014-09-26
DOI10.1016/j.neuroscience.2014.06.064
277页:103-110
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者National Natural Science Foundation of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Basic Research Program of China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]GROWTH-ASSOCIATED MOLECULE ; MESSENGER-RNA ; CEREBRAL-ISCHEMIA ; REACTIVE ASTROCYTES ; FUNCTIONAL RECOVERY ; NEUROTROPHIC FACTOR ; PROTECTS BRAIN ; UP-REGULATION ; IN-VITRO ; PLEIOTROPHIN
英文摘要

Cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide that plays neuroprotective roles in cerebral ischemia and reperfusion (I/R) injury in animal models or oxygen and glucose deprivation (OGD) in cultured neurons. Recent data suggest that intranasal CART treatment facilitates neuroregeneration in stroke brain. However, little is known about the effects of post-treatment with CART during the neuronal recovery after OGD and reoxygenation in cultured primary cortical neurons. The present study was to investigate the role of CART treated after OGD injury in neurons. Primary mouse cortical neurons were subjected to OGD and then treated with CART. Our data show that post-treatment with CART reduced the neuronal apoptosis caused by OGD injury. In addition, CART repaired OGDimpaired cortical neurons by increasing the expression of growth-associated protein 43 (GAP43), which promotes neurite outgrowth. This effect depends on pleiotrophin (PTN) as siRNA- mediated PTN knockdown totally abolished the increase in CART-stimulated GAP43 protein levels. In summary, our findings demonstrate that CART repairs the neuronal injury after OGD by facilitating neurite outgrowth through PTN-dependent pathway. The role for CART in neurite outgrowth makes it a new potential therapeutic agent for the treatment of neurodegenerative diseases. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

语种英语
所属项目编号81171081 ; 2014CB542200
资助者National Natural Science Foundation of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Basic Research Program of China
WOS记录号WOS:000341488700010
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54552
Collection北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Wang, Y.,Qiu, B.,Liu, J.,et al. COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT FACILITATES THE NEURITE OUTGROWTH IN CORTICAL NEURONS AFTER OXYGEN AND GLUCOSE DEPRIVATION THROUGH PTN-DEPENDENT PATHWAY[J]. NEUROSCIENCE,2014,277:103-110.
APA Wang, Y.,Qiu, B.,Liu, J.,Zhu, Wei-Guo,&Zhu, S..(2014).COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT FACILITATES THE NEURITE OUTGROWTH IN CORTICAL NEURONS AFTER OXYGEN AND GLUCOSE DEPRIVATION THROUGH PTN-DEPENDENT PATHWAY.NEUROSCIENCE,277,103-110.
MLA Wang, Y.,et al."COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT FACILITATES THE NEURITE OUTGROWTH IN CORTICAL NEURONS AFTER OXYGEN AND GLUCOSE DEPRIVATION THROUGH PTN-DEPENDENT PATHWAY".NEUROSCIENCE 277(2014):103-110.
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