IR@PKUHSC  > 北京大学临床肿瘤学院  > 超声科
学科主题临床医学
High mechanical index post-contrast ultrasonography improves tissue structural display of hepatocellular carcinoma
Chen, MH; Yang, W; Dai, Y; Wu, W
关键词Ultrasonography Contrast Enhanced Ultrasound Liver Neoplasm Tissue Structure
刊名CHINESE MEDICAL JOURNAL
2005-12-20
118期:24页:2046-2051
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]FOCAL LIVER-LESIONS ; MICROBUBBLE CONTRAST ; HEPATIC-LESIONS ; BLOOD-FLOW ; AGENT ; ULTRASOUND ; SONOVUE ; US ; DIFFERENTIATION ; PATTERNS
英文摘要

Background The advent of second generation agent-SonoVue and low mechanical index real-time contrast enhanced ultrasonography ( CEUS) imaging have been shown to improve the diagnostic performance of ultrasonography in hepatocellular carcinoma ( HCC). But no report has described the effect of high mechanical index ( MI) post-CEUS. This study aimed to investigate the value of post-CEUS in displaying tissue structures of HCC.

Methods Seventy-six HCCs in 65 patients were included in the study. Each patient underwent three scans, high-MI ( MI: 0. 15 - 1. 6) pre-contrast ultrasound, low-MI ( MI: 0. 04 - 0. 08) CEUS with contrast agent SonoVue, and high-MI post-contrast ultrasound, which was performed within 3 minutes after CEUS. The size, boundary, echogenicity, internal echotexture and posterior acoustic enhancement of the HCCs in the conventional scans before and after CEUS were evaluated. According to pathological evidence, diagnosis rates of pre-contrast, CEUS and post-contrast scans were determined and compared. The potential mechanism of post-contrast ultrasound imaging was also discussed.

Results Compared with pre-contrast, post-contrast ultrasound showed improvement in image quality in most HCCs : twenty-six (34.2%) more lesions showed well defined margins and fourteen ( 18.4%) more nodules showed halo sign; twenty-three (30.3 %) lesions demonstrated enlarged in sizes; changes in echogenicity were seen in 30 lesions (39.5%); eighteen (23.7 %) more lesions showed heterogenecity and 20 (26.3 %) more lesions showed "mosaic" or "nodule-in-nodule" sign; twelve (15.8%) more lesions showed posterior acoustic enhancement. Post-contrast ultrasound showed increased diagnostic accuracy of 93.4% (71/76), compare with 88.2% (67/76) of CEUS alone.

Conclusions High-MI post-contrast ultrasound utilizes harmonic signals during the rupture of microbubbles, and significantly improves the display of echo-characteristics of HCCs in ultrasound images, which adds diagnostic values for CEUS. Post-contrast ultrasound could play an important role in tissue characterization, and may be included in CEUS protocols.

语种英语
WOS记录号WOS:000234330600004
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54554
Collection北京大学临床肿瘤学院_超声科
作者单位Peking Univ, Sch Oncol, Dept Ultrasound, Beijing 100036, Peoples R China
Recommended Citation
GB/T 7714
Chen, MH,Yang, W,Dai, Y,et al. High mechanical index post-contrast ultrasonography improves tissue structural display of hepatocellular carcinoma[J]. CHINESE MEDICAL JOURNAL,2005,118(24):2046-2051.
APA Chen, MH,Yang, W,Dai, Y,&Wu, W.(2005).High mechanical index post-contrast ultrasonography improves tissue structural display of hepatocellular carcinoma.CHINESE MEDICAL JOURNAL,118(24),2046-2051.
MLA Chen, MH,et al."High mechanical index post-contrast ultrasonography improves tissue structural display of hepatocellular carcinoma".CHINESE MEDICAL JOURNAL 118.24(2005):2046-2051.
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