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学科主题药学
Nanoscaled Polyion Complex Micelles for Targeted Delivery of Recombinant Hirudin to Platelets Based on Cationic Copolymer
Wang, Fei1; Li, Xinru1; Zhou, Yanxia1; Zhang, Yanhui1; Chen, Xingwei1; Yang, Jingxiong1; Huang, Yanqing2; Liu, Yan1
关键词Recombinant Hirudin Polyion Complex Micelles Platelet-targeted Poly(Ethylene Glycol)-grafted-chitosan Anticoagulant Activity Inhibition Of Platelet Aggregation
刊名MOLECULAR PHARMACEUTICS
2010-05-01
DOI10.1021/mp900271r
7期:3页:718-726
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]IN-VIVO CHARACTERIZATION ; PEG-GRAFTED CHITOSAN ; BLOCK-COPOLYMER ; CAPILLARY-ELECTROPHORESIS ; CONTROLLED-RELEASE ; DRUG-DELIVERY ; THROMBIN ; HEPARIN ; VITRO ; CORE
英文摘要

Polyion complex (PIC) micelles based on methoxy poly(ethylene glycol)-grafted-chitosan (mPEG-g-chitosan) and Arg-Gly-Asp conjugated poly(ethylene glycol)-grafted-chitosan (RGD-PEG-g-chitosan) were designed as carriers for platelet-targeted delivery of recombinant hirudin variant-2 (rHV2). The rHV2-loaded plain PIC micelles (mPIC micelles) and RGD conjugated PIC micelles (RGD-PIC micelles) were successfully prepared with mean size of 30.9 +/- 0.5 nm and 41.9 +/- 1.8 nm, and their encapsulation efficiencies were 76.90 +/- 0.84% and 81.08 +/- 0.85%, respectively. The pharmacokinetics experiments showed that the mean retention time (MRT) of rHV2 encapsulated in both kinds of micelles was significantly prolonged, especially for mPIC micelles. The confocal laser scanning microscopy intuitively proved the specific binding of RGD-PIC micelles to platelets. The efficacies of rHV2-loaded RGD-PIC micelles were greatly better than those of rHV2-loaded mPIC micelles and rHV2 solution in aspect of anticoagulation and inhibition of platelet aggregation. These results suggested platelet-targeting specificity of RGD-PIC micelles and that RGD PIC micelles could potentially be used as a carrier for platelet-targeted delivery and long circulation of rHV2.

语种英语
WOS记录号WOS:000278452100010
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54555
专题北京大学药学院_药剂学系
作者单位1.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Pharmaceut Teaching Lab Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Fei,Li, Xinru,Zhou, Yanxia,et al. Nanoscaled Polyion Complex Micelles for Targeted Delivery of Recombinant Hirudin to Platelets Based on Cationic Copolymer[J]. MOLECULAR PHARMACEUTICS,2010,7(3):718-726.
APA Wang, Fei.,Li, Xinru.,Zhou, Yanxia.,Zhang, Yanhui.,Chen, Xingwei.,...&Liu, Yan.(2010).Nanoscaled Polyion Complex Micelles for Targeted Delivery of Recombinant Hirudin to Platelets Based on Cationic Copolymer.MOLECULAR PHARMACEUTICS,7(3),718-726.
MLA Wang, Fei,et al."Nanoscaled Polyion Complex Micelles for Targeted Delivery of Recombinant Hirudin to Platelets Based on Cationic Copolymer".MOLECULAR PHARMACEUTICS 7.3(2010):718-726.
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