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IR@PKUHSC  > 北京大学临床肿瘤学院  > 流行病学研究室  > 期刊论文
学科主题: 临床医学
题名:
RUNX3 methylation and expression associated with advanced precancerous gastric lesions in a Chinese population
作者: Li, Wen-Qing1; Pan, Kai-Feng1; Zhang, Yang1; Dong, Cai-Xuan1; Zhang, Lian1; Ma, Jun-Ling1; Zhou, Tong1; Li, Ji-You2; You, Wei-Cheng1
刊名: CARCINOGENESIS
发表日期: 2011-03-01
DOI: 10.1093/carcin/bgq259
卷: 32, 期:3, 页:406-410
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HELICOBACTER-PYLORI INFECTION ; PROMOTER METHYLATION ; EPITHELIAL-CELLS ; HIGH-RISK ; TUMOR-SUPPRESSOR ; STOMACH-CANCER ; CPG ISLANDS ; GROWTH ; GENE ; CARCINOMA
英文摘要:

Runt-related transcription factor 3 (RUNX3) is a tumor suppressor of gastric cancer. Our study aimed to investigate the correlation of RUNX3 methylation, expression and the risk of advanced gastric lesions, based on a high-risk population in Linqu County, Shandong Province, China. Methylation status of RUNX3 was determined by methylation-specific polymerase chain reaction, and expression was detected by immunohistochemical analysis in 1113 subjects with different gastric lesions. Results showed that the frequency of RUNX3 methylation was significantly increased in subjects with advanced gastric lesions. The odds ratios (ORs) were 2.09 [95% confidence interval (CI): 1.49-2.94] for intestinal metaplasia (IM), 3.22 (95% CI: 2.33-4.47) for indefinite dysplasia (Ind DYS) and 2.03 (95% CI: 1.23-3.37) for dysplasia (DYS) compared with superficial gastritis/chronic atrophic gastritis. Stratified analysis indicated that the frequency of RUNX3 methylation was higher in subjects with Helicobacter pylori infection (OR, 2.74; 95% CI: 2.00-3.76). Moreover, there was a reverse grade-response relationship between the level of RUNX3 expression and risk of gastric lesions. Among subjects with mild, moderate or heavy expression, the risk was decreased by 41, 59 or 80% for IM (P(trend) < 0.0001); 40, 64 or 74% for Ind DYS (P(trend) < 0.0001) and 28, 59 or 51% for DYS (P(trend) = 0.045), respectively. Furthermore, RUNX3 expression was negatively associated with increased frequency of RUNX3 methylation (OR, 0.76; 95% CI: 0.59-0.98). These findings suggest that RUNX3 may play important roles in the development of advanced gastric lesions.

语种: 英语
所属项目编号: 2006AA02A402 ; 2010CB529303 ; 30772515 ; 30921140311
项目资助者: National High Technology RD Program (863) ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Natural Science Foundation of China
WOS记录号: WOS:000288027800021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54556
Appears in Collections:北京大学临床肿瘤学院_流行病学研究室_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res Minist Educ, Dept Canc Epidemiol, Beijing 100142, Peoples R China
2.Peking Univ, Dept Pathol, Canc Hosp & Inst, Beijing 100142, Peoples R China

Recommended Citation:
Li, Wen-Qing,Pan, Kai-Feng,Zhang, Yang,et al. RUNX3 methylation and expression associated with advanced precancerous gastric lesions in a Chinese population[J]. CARCINOGENESIS,2011,32(3):406-410.
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