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学科主题: 基础医学
题名:
Insulin Induces C2C12 Cell Proliferation and Apoptosis Through Regulation of Cyclin D1 and BAD Expression
作者: Xiong, Cheng-Juan1; Li, Ping-Fa2; Song, Yang-Liu1; Xue, Li-Xiang3; Jia, Zhu-Qing3; Yao, Chun-Xia1; Wei, Qing-Xia1; Zhang, Shu-Feng4; Zhang, Shan-Feng1; Zhang, Yan-Yan5; Zhao, Ji-Min1; Wang, Tian-Qi1; Guo, Mao-Feng1; Zang, Ming-Xi1
关键词: INSULIN ; CELL ; GROWTH ; CELL ; APOPTOSIS ; CYCLIN D1 ; BAD
刊名: JOURNAL OF CELLULAR BIOCHEMISTRY
发表日期: 2013-12-01
DOI: 10.1002/jcb.24619
卷: 114, 期:12, 页:2708-2717
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: CARDIOMYOCYTE PROLIFERATION ; PPAR-ALPHA ; ESTROGEN-RECEPTOR ; GENE-EXPRESSION ; GLUCOSE-UPTAKE ; BREAST-CANCER ; DIFFERENTIATION ; MUSCLE ; ACTIVATION ; GROWTH
英文摘要:

Insulin is a secreted peptide hormone identified in human pancreas to promote glucose utilization. Insulin has been observed to induce cell proliferation and myogenesis in C2C12 cells. The precise mechanisms underlying the proliferation of C2C12 cells induced by insulin remain unclear. In this study, we observed for the first time that 10nM insulin treatment promotes C2C12 cell proliferation. Additionally, 50 and 100nM insulin treatment induces C2C12 cell apoptosis. By utilizing real-time PCR and Western blotting analysis, we found that the mRNA levels of cyclinD1 and BAD are induced upon 10 and 50nM/100nM insulin treatment, respectively. The similar results were observed in C2C12 cells expressing GATA-6 or PPAR. Our results identify for the first time the downstream targets of insulin, cyclin D1, and BAD, elucidate a new molecular mechanism of insulin in promoting cell proliferation and apoptosis. J. Cell. Biochem. 114: 2708-2717, 2013. (c) 2013 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 2007AA02Z122 ; 2012AA022501 ; 81141044 ; 31071206 ; 082102310024 ; 104300510016
项目资助者: Ministry of Science and Technology of China 863 Program ; National Natural Science Foundation of China ; International Cooperation and Exchange Foundation of Henan Scientific Committee ; Scientific Research Foundation for the Returned Overseas Chinese Scholars ; State Education Ministry ; Ministry of Personnel ; Henan University Key Teacher Foundation
WOS记录号: WOS:000328478100008
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54558
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Zhengzhou Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Zhengzhou 450001, Henan, Peoples R China
2.Xinxiang Med Univ, Dept Lab Med, Xinxiang City 453003, Henan, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100191, Peoples R China
4.Zhengzhou Univ, Peoples Hosp Henan Prov, Zhengzhou 450001, Henan, Peoples R China
5.Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China

Recommended Citation:
Xiong, Cheng-Juan,Li, Ping-Fa,Song, Yang-Liu,et al. Insulin Induces C2C12 Cell Proliferation and Apoptosis Through Regulation of Cyclin D1 and BAD Expression[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2013,114(12):2708-2717.
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