IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Zinc-finger protein ZNF165 is a novel cancer-testis antigen capable of eliciting antibody response in hepatocellular carcinoma patients
Dong, XY; Yang, XA; Wang, YD; Chen, WF
关键词zinc-finger protein transcription factor cancer-testis antigen serum antibody tumorigenesis
刊名BRITISH JOURNAL OF CANCER
2004-10-18
DOI10.1038/sj.bjc.6602138
91期:8页:1566-1570
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CANCER/TESTIS ANTIGENS ; GENE ; TRANSCRIPTION ; TUMOR ; IMMUNOTHERAPY ; FAMILY
英文摘要

ZNF165 is a zinc-finger protein gene that was identified from human adult testis. Analysis of the origins of publicly available expressed sequence tags as presented in Unigene and SAGE databases revealed that ZNF165 mRNA was expressed in tumours of different tissues. RT-PCR, real-time PCR and Northern blotting analysis confirmed that ZNF165 mRNA was expressed in the hepatocellular carcinoma, gastric cancer, colon cancer and non-small-cell lung carcinoma. The nucleotide sequence of ZNF165 expressed in tumours is identical to that expressed in the testis. Humoral responses of hepatocellular carcinoma (HCC) patients against ZNF165 protein were determined by Western blotting using the recombinant ZNF165 protein. Antibodies against ZNF165 protein were detected in approximately 5% (four of 82) of the sera from HCC patients. These results suggest that ZNF165, a member of the ZNF family, is a novel CT antigen capable of eliciting humoral immune response and be involved in tumour biology.

语种英语
WOS记录号WOS:000224412500025
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54565
Collection北京大学基础医学院_免疫学系
作者单位Peking Univ, Dept Immunol, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Dong, XY,Yang, XA,Wang, YD,et al. Zinc-finger protein ZNF165 is a novel cancer-testis antigen capable of eliciting antibody response in hepatocellular carcinoma patients[J]. BRITISH JOURNAL OF CANCER,2004,91(8):1566-1570.
APA Dong, XY,Yang, XA,Wang, YD,&Chen, WF.(2004).Zinc-finger protein ZNF165 is a novel cancer-testis antigen capable of eliciting antibody response in hepatocellular carcinoma patients.BRITISH JOURNAL OF CANCER,91(8),1566-1570.
MLA Dong, XY,et al."Zinc-finger protein ZNF165 is a novel cancer-testis antigen capable of eliciting antibody response in hepatocellular carcinoma patients".BRITISH JOURNAL OF CANCER 91.8(2004):1566-1570.
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