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学科主题: 基础医学
题名:
Zinc-finger protein ZNF165 is a novel cancer-testis antigen capable of eliciting antibody response in hepatocellular carcinoma patients
作者: Dong, XY; Yang, XA; Wang, YD; Chen, WF
关键词: zinc-finger protein ; transcription factor ; cancer-testis antigen ; serum antibody ; tumorigenesis
刊名: BRITISH JOURNAL OF CANCER
发表日期: 2004-10-18
DOI: 10.1038/sj.bjc.6602138
卷: 91, 期:8, 页:1566-1570
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CANCER/TESTIS ANTIGENS ; GENE ; TRANSCRIPTION ; TUMOR ; IMMUNOTHERAPY ; FAMILY
英文摘要:

ZNF165 is a zinc-finger protein gene that was identified from human adult testis. Analysis of the origins of publicly available expressed sequence tags as presented in Unigene and SAGE databases revealed that ZNF165 mRNA was expressed in tumours of different tissues. RT-PCR, real-time PCR and Northern blotting analysis confirmed that ZNF165 mRNA was expressed in the hepatocellular carcinoma, gastric cancer, colon cancer and non-small-cell lung carcinoma. The nucleotide sequence of ZNF165 expressed in tumours is identical to that expressed in the testis. Humoral responses of hepatocellular carcinoma (HCC) patients against ZNF165 protein were determined by Western blotting using the recombinant ZNF165 protein. Antibodies against ZNF165 protein were detected in approximately 5% (four of 82) of the sera from HCC patients. These results suggest that ZNF165, a member of the ZNF family, is a novel CT antigen capable of eliciting humoral immune response and be involved in tumour biology.

语种: 英语
WOS记录号: WOS:000224412500025
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54565
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: Peking Univ, Dept Immunol, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Dong, XY,Yang, XA,Wang, YD,et al. Zinc-finger protein ZNF165 is a novel cancer-testis antigen capable of eliciting antibody response in hepatocellular carcinoma patients[J]. BRITISH JOURNAL OF CANCER,2004,91(8):1566-1570.
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