|The Effect of Thalassemia on Erythrocyte Reference Intervals in a Representative Han Chinese Adult Population|
|Xu, Jian-Hua1; Hao, Xiao-Ke2; Mu, Run-Qing3; Pan, Bai-Shen4; Zhang, Jie5; Peng, Ming-Ting6; Wang, Lan-Lan7; Huang, Xian-Zhang1; Ma, Yue-Yun2; Zhao, Min3; Guo, Wei4; Qiao, Rui5; Chen, Wen-Xiang6; Jiang, Hong7; Shang, Hong3|
|关键词||Thalassemia Reference Intervals Erythrocyte Indices Genotypic Diagnosis|
|WOS标题词||Science & Technology|
|类目[WOS]||Medical Laboratory Technology|
|研究领域[WOS]||Medical Laboratory Technology|
|关键词[WOS]||BETA-THALASSEMIA ; REFERENCE VALUES ; HIGH PREVALENCE ; HEALTHY-ADULTS ; SOUTHERN CHINA ; HEMOGLOBINOPATHIES ; GENOTYPES ; AREAS|
Background: The data from apparently healthy individuals with thalassemia has been demonstrated to have an effect on the reference intervals for the erythrocyte indices in areas with a high incidence of thalassemia.
Methods: Six clinical centers screened apparently healthy individuals using a questionnaire and a physical examination. Then, the qualified reference individuals were selected by hematological indices and a genotypic thalassemia diagnosis. Statistical comparisons were conducted for the erythrocyte reference intervals in the Chinese population with and without thalassemia. The constituent ratios and the mean (SD) of erythrocyte indices according to the thalassemia genotype were calculated. The relationship between the MCV values and the thalassemia genotype was also estimated.
Results: 4,636 reference individuals were included using hematological indices and genotypic thalassemia screening. The results of the erythrocyte reference intervals for individuals in Guangzhou with thalassemia demonstrated that the RBC, MCV, and MCH values significantly differed by gender compared with other regions (p < 0.01). In contrast, for individuals without thalassemia, the results tended to be similar and clinically acceptable. In addition, the results of the erythrocyte indices revealed significant differences among alpha-thalassemia patients, beta-thalassemia patients, and the control group.
Conclusions: Apparently healthy individuals with thalassemia in the high prevalence zone of thalassemia could not be excluded by the questionnaire, physical examination or laboratory indices (Fe < 6 mu mol/L, Hb < 90 g/L). The screening of genotypic thalassemia based on the MCV or MCH values to exclude unqualified individuals is the most effective way to obtain accurate and reliable reference intervals for the erythrocyte indices.
|作者单位||1.Beijing Hosp, Natl Ctr Clin Labs, Beijing, Peoples R China|
2.Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Lab Sci, Guangzhou, Guangdong, Peoples R China
3.Fourth Mil Med Univ, Xijing Hosp, Dept Clin Lab Med, Xian 710032, Shaanxi, Peoples R China
4.China Med Univ, Affiliated Hosp 1, Dept Clin Lab Med, Shenyang 110001, Peoples R China
5.Fudan Univ, Zhongshan Hosp, Dept Clin Lab Med, Shanghai 200433, Peoples R China
6.Peking Univ, Dept Lab Med, Hosp 3, Beijing 100871, Peoples R China
7.Sichuan Univ, West China Hosp, Dept Lab Med, Chengdu, Sichuan, Peoples R China
|Xu, Jian-Hua,Hao, Xiao-Ke,Mu, Run-Qing,et al. The Effect of Thalassemia on Erythrocyte Reference Intervals in a Representative Han Chinese Adult Population[J]. CLINICAL LABORATORY,2015,61(3-4):405-414.|
|APA||Xu, Jian-Hua.,Hao, Xiao-Ke.,Mu, Run-Qing.,Pan, Bai-Shen.,Zhang, Jie.,...&Shang, Hong.(2015).The Effect of Thalassemia on Erythrocyte Reference Intervals in a Representative Han Chinese Adult Population.CLINICAL LABORATORY,61(3-4),405-414.|
|MLA||Xu, Jian-Hua,et al."The Effect of Thalassemia on Erythrocyte Reference Intervals in a Representative Han Chinese Adult Population".CLINICAL LABORATORY 61.3-4(2015):405-414.|