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Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw
Fu, KY; Light, AR; Maixner, W
关键词Hyperalgesia Inflammation Pain Formalin Rat
刊名JOURNAL OF PAIN
2001-02-01
DOI10.1054/jpai.2001.9804
2期:1页:2-11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NITRIC-OXIDE FORMATION ; CENTRAL-NERVOUS-SYSTEM ; INDUCED TISSUE-INJURY ; SUBSTANCE-P ; SPINAL-CORD ; ACTIVATED MICROGLIA ; CYCLOOXYGENASE INHIBITION ; PERSISTENT NOCICEPTION ; POSTOPERATIVE PAIN ; PROSTAGLANDIN E(2)
英文摘要

Subcutaneous formalin injection is widely used as a nociceptive stimulus in the rat. This procedure evokes overt behaviors that last about 90 minutes. However, little is known about the duration of paw inflammation and alterations in pain sensitivity to noxious stimuli after 2 hours. We studied the nociceptive responses to thermal and mechanical stimuli 2 hours to 4 weeks after formalin injection into the dorsal or plantar side of the hindpaw. Thirty-two adult male Sprague-Dawley rats were divided into 3 groups: In group I, 50 muL of 5% formalin was injected into the plantar side (n = 12); in group II, 50 muL of 5% formalin was injected into the dorsal side (n = 12); in group III, 50 muL saline was injected into the dorsal or plantar side of the hindpaw (n = 8). Nociceptive responses to thermal and mechanical stimuli applied to the dorsal or plantar surfaces of the injected and the contralateral hindpaws were recorded. The injection of formalin into the rat′s hindpaw produced a hypoalgesic region around the injection site. In contrast, hyperalgesic responses to thermal and mechanical stimulation were induced on the opposite surface of the injected hindpaw as well as in the contralateral noninjected hindpaw. The hyperalgesic responses, which were observed 2 hours after formalin administration, were enhanced 1 to 3 days after injection and lasted 3 to 4 weeks. These results suggest that peripheral inflammation after subcutaneous formalin injection produces a long-lasting sensitization. Possible mechanisms for these changes in nociception are discussed.

语种英语
WOS记录号WOS:000166922300001
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被引频次:84[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54576
专题北京大学口腔医学院
作者单位1.Beijing Med Univ, Sch Stomatol, Beijing 100083, Peoples R China
2.Univ N Carolina, Dept Cell & Mol Physiol, Dent Res Ctr, Chapel Hill, NC USA
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Fu, KY,Light, AR,Maixner, W. Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw[J]. JOURNAL OF PAIN,2001,2(1):2-11.
APA Fu, KY,Light, AR,&Maixner, W.(2001).Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw.JOURNAL OF PAIN,2(1),2-11.
MLA Fu, KY,et al."Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw".JOURNAL OF PAIN 2.1(2001):2-11.
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