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学科主题: 口腔医学
题名:
Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw
作者: Fu, KY; Light, AR; Maixner, W
关键词: hyperalgesia ; inflammation ; pain ; formalin ; rat
刊名: JOURNAL OF PAIN
发表日期: 2001-02-01
DOI: 10.1054/jpai.2001.9804
卷: 2, 期:1, 页:2-11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NITRIC-OXIDE FORMATION ; CENTRAL-NERVOUS-SYSTEM ; INDUCED TISSUE-INJURY ; SUBSTANCE-P ; SPINAL-CORD ; ACTIVATED MICROGLIA ; CYCLOOXYGENASE INHIBITION ; PERSISTENT NOCICEPTION ; POSTOPERATIVE PAIN ; PROSTAGLANDIN E(2)
英文摘要:

Subcutaneous formalin injection is widely used as a nociceptive stimulus in the rat. This procedure evokes overt behaviors that last about 90 minutes. However, little is known about the duration of paw inflammation and alterations in pain sensitivity to noxious stimuli after 2 hours. We studied the nociceptive responses to thermal and mechanical stimuli 2 hours to 4 weeks after formalin injection into the dorsal or plantar side of the hindpaw. Thirty-two adult male Sprague-Dawley rats were divided into 3 groups: In group I, 50 muL of 5% formalin was injected into the plantar side (n = 12); in group II, 50 muL of 5% formalin was injected into the dorsal side (n = 12); in group III, 50 muL saline was injected into the dorsal or plantar side of the hindpaw (n = 8). Nociceptive responses to thermal and mechanical stimuli applied to the dorsal or plantar surfaces of the injected and the contralateral hindpaws were recorded. The injection of formalin into the rat′s hindpaw produced a hypoalgesic region around the injection site. In contrast, hyperalgesic responses to thermal and mechanical stimulation were induced on the opposite surface of the injected hindpaw as well as in the contralateral noninjected hindpaw. The hyperalgesic responses, which were observed 2 hours after formalin administration, were enhanced 1 to 3 days after injection and lasted 3 to 4 weeks. These results suggest that peripheral inflammation after subcutaneous formalin injection produces a long-lasting sensitization. Possible mechanisms for these changes in nociception are discussed.

语种: 英语
WOS记录号: WOS:000166922300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54576
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Beijing Med Univ, Sch Stomatol, Beijing 100083, Peoples R China
2.Univ N Carolina, Dept Cell & Mol Physiol, Dent Res Ctr, Chapel Hill, NC USA

Recommended Citation:
Fu, KY,Light, AR,Maixner, W. Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw[J]. JOURNAL OF PAIN,2001,2(1):2-11.
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