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Both p53-PUMA/NOXA-Bax-mitochondrion and p53-p21cip1 pathways are involved in the CDglyTK-mediated tumor cell suppression
Yu, Zhendong1; Wang, Hao2; Zhang, Libin1; Tang, Aifa1; Zhai, Qinna1; Wen, Jianxiang1; Yao, Li1; Li, Pengfei2
关键词Cdglytk P53 Nasopharyngeal Carcinoma (Npc) Gene Therapy Puma Noxa Bax Bcl2 P21
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2009-09-04
DOI10.1016/j.bbrc.2009.06.083
386期:4页:607-611
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]NASOPHARYNGEAL CARCINOMA ; GENE-THERAPY ; CYTOSINE DEAMINASE ; THYMIDINE KINASE ; GLIOMA-CELLS ; CANCER-CELLS ; P53 ; APOPTOSIS ; SUICIDE ; CHEMOSENSITIVITY
英文摘要

CDglyTK fusion suicide gene has been well characterized to effectively kill tumor cells. However, the exact mechanism and downstream target genes are not fully understood. In our Study, we found that CDglyTK/prodrug treatment works more efficiently in p53 wild-type (HONE1) cells than in p53 mutant (CNE1) cells. We then used adenovirus-mediated gene delivery system to either knockdown or overexpress p53 and its target genes in these cells. Consistent results showed that both p53-PUMA/NOXA/Bcl2-Bax and p53-p21 pathways contribute to the CDglyTK induced tumor cell suppression. Our work for the first time addressed the role of p53 related genes in the CDglyTK/prodrug system. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000268462100012
项目编号2008B03031280 ; 200802007
资助机构Science and Technology Planning Project of Guangdong Province, China ; Science and Technology Planning Project of Shenzhen, China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54578
专题北京大学深圳医院
作者单位1.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China
2.Chinese Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Yu, Zhendong,Wang, Hao,Zhang, Libin,et al. Both p53-PUMA/NOXA-Bax-mitochondrion and p53-p21cip1 pathways are involved in the CDglyTK-mediated tumor cell suppression[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,386(4):607-611.
APA Yu, Zhendong.,Wang, Hao.,Zhang, Libin.,Tang, Aifa.,Zhai, Qinna.,...&Li, Pengfei.(2009).Both p53-PUMA/NOXA-Bax-mitochondrion and p53-p21cip1 pathways are involved in the CDglyTK-mediated tumor cell suppression.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,386(4),607-611.
MLA Yu, Zhendong,et al."Both p53-PUMA/NOXA-Bax-mitochondrion and p53-p21cip1 pathways are involved in the CDglyTK-mediated tumor cell suppression".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 386.4(2009):607-611.
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