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学科主题: 临床医学
题名:
Both p53-PUMA/NOXA-Bax-mitochondrion and p53-p21cip1 pathways are involved in the CDglyTK-mediated tumor cell suppression
作者: Yu, Zhendong1; Wang, Hao2; Zhang, Libin1; Tang, Aifa1; Zhai, Qinna1; Wen, Jianxiang1; Yao, Li1; Li, Pengfei2
关键词: CDglyTK ; p53 ; Nasopharyngeal carcinoma (NPC) ; Gene therapy ; PUMA ; NOXA ; Bax ; Bcl2 ; p21
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2009-09-04
DOI: 10.1016/j.bbrc.2009.06.083
卷: 386, 期:4, 页:607-611
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: NASOPHARYNGEAL CARCINOMA ; GENE-THERAPY ; CYTOSINE DEAMINASE ; THYMIDINE KINASE ; GLIOMA-CELLS ; CANCER-CELLS ; P53 ; APOPTOSIS ; SUICIDE ; CHEMOSENSITIVITY
英文摘要:

CDglyTK fusion suicide gene has been well characterized to effectively kill tumor cells. However, the exact mechanism and downstream target genes are not fully understood. In our Study, we found that CDglyTK/prodrug treatment works more efficiently in p53 wild-type (HONE1) cells than in p53 mutant (CNE1) cells. We then used adenovirus-mediated gene delivery system to either knockdown or overexpress p53 and its target genes in these cells. Consistent results showed that both p53-PUMA/NOXA/Bcl2-Bax and p53-p21 pathways contribute to the CDglyTK induced tumor cell suppression. Our work for the first time addressed the role of p53 related genes in the CDglyTK/prodrug system. (C) 2009 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2008B03031280 ; 200802007
项目资助者: Science and Technology Planning Project of Guangdong Province, China ; Science and Technology Planning Project of Shenzhen, China
WOS记录号: WOS:000268462100012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54578
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China
2.Chinese Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Yu, Zhendong,Wang, Hao,Zhang, Libin,et al. Both p53-PUMA/NOXA-Bax-mitochondrion and p53-p21cip1 pathways are involved in the CDglyTK-mediated tumor cell suppression[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,386(4):607-611.
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