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学科主题: 基础医学
题名:
Family with sequence similarity 3 gene family and nonalcoholic fatty liver disease
作者: Yang, Jichun1,2; Guan, Youfei1,2
关键词: FAM3 gene family ; NAFLD ; PANDER ; steatosis
刊名: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
发表日期: 2013-08-01
DOI: 10.1111/jgh.12033
卷: suppl.1, 期:SI, 页:105-111
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: PANCREATIC-DERIVED FACTOR ; ISLET AMYLOID POLYPEPTIDE ; SECRETING BETA-CELLS ; FACTOR PANDER ; INSULIN-RESISTANCE ; FACTOR FAM3B ; PPAR-GAMMA ; FASTING HYPERGLYCEMIA ; DEPENDENT REGULATION ; HEPATIC STEATOSIS
英文摘要:

Nonalcoholic fatty liver disease (NAFLD) comprises a disease spectrum ranging from simple steatosis (fatty liver) and nonalcoholic steatohepatitis to fibrosis and cirrhosis. NAFLD has become the leading cause of chronic liver diseases as well as liver-related morbidity and mortality worldwide. NAFLD is also associated with increased risk of cardiovascular diseases, hyperlipidemia, and type2 diabetes. Insulin resistance in adipose tissues and the liver plays crucial roles in the progression of NAFLD. The family with sequence similarity 3 (FAM3) gene family is a cytokine-like gene family with four members designated FAM3A, FAM3B, FAM3C, and FAM3D, respectively. Increasing evidence suggests that the FAM3 gene family members are involved in the pathogenesis of NAFLD. In particular, FAM3B, also called pancreatic-derived factor, is an important regulator of glucose and lipid metabolism. In obesity status, increased expression and secretion of FAM3B in pancreatic islets and liver may induce lipid accumulation in the liver via the induction of hepatic insulin resistance and lipogenesis. FAM3A and FAM3D may also participate in the regulation of lipid and energy metabolism. In this brief review, we discussed the latest findings regarding the role of FAM3 gene family members, in particular FAM3B, in the pathogenesis of NAFLD.

语种: 英语
所属项目编号: 2011ZX09102 ; 81170791/8103003/81121061/30890041 ; 7122107 ; 7122107
项目资助者: Ministry of Science and Technology ; Natural Science Foundation ; AstraZeneca Investment (China) Co., Ltd. ; Beijing Natural Science Foundation
WOS记录号: WOS:000329463400018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54581
Appears in Collections:基础医学院_北京大学糖尿病中心_期刊论文

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作者单位: 1.Peking Univ, Ctr Diabet, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Key Lab Mol Cardiovasc Sci Minist Educ, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Jichun,Guan, Youfei. Family with sequence similarity 3 gene family and nonalcoholic fatty liver disease[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2013,suppl.1(SI):105-111.
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