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学科主题: 精神卫生
题名:
BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia
作者: Zhang, Xiang Yang1,2,3; Zhou, Dong Feng2; Wu, Gui Ying3; Cao, Lian Yuan3; Tan, Yun Long3; Haile, Colin N.; Li, Jun4; Lu, Lin5; Kosten, Therese A.; Kosten, Thomas R.
关键词: schizophrenia ; antipsychotic ; weight gain ; BDNF ; genotype ; association
刊名: NEUROPSYCHOPHARMACOLOGY
发表日期: 2008-08-01
DOI: 10.1038/sj.npp.1301619
卷: 33, 期:9, 页:2200-2205
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: NEUROTROPHIC FACTOR ; ATYPICAL ANTIPSYCHOTICS ; MELANOCORTIN-4 RECEPTOR ; GENE POLYMORPHISM ; ENERGY-BALANCE ; DIABETIC MICE ; RAT-BRAIN ; OBESITY ; PHARMACOGENETICS ; MANAGEMENT
英文摘要:

Recent evidence suggests that centrally released brain-derived neurotrophic factor ( BDNF) modulates eating behavior and metabolism that is responsible for body weight fluctuation. BDNF also may play an important role in the therapeutic action of antipsychotic medications. We investigated whether the Val66Met polymorphism of the BDNF gene affected weight gain after long-term antipsychotic treatment in schizophrenia. The polymorphism was genotyped in 196 Chinese patients with schizophrenia on long-term antipsychotic medication. Serum BDNF was measured in all patients and 50 normal controls. Mean body mass index (BMI) change was evaluated retrospectively by means of clinical records. The results showed that there was a significant relationship between the three BDNF Val/Met genotypes and mean BMI gain, with genotype having a strong effect on BMI gain in male but not female patients. BDNF levels were significantly lower in patients than normal controls, and negatively correlated with BMI gain in female but not male patients. Our results suggest that variation in the BDNF gene may be a risk factor for weight gain in male patients with schizophrenia on long-term antipsychotic treatment, and decreased BDNF levels may be associated with weight gain in females.

语种: 英语
WOS记录号: WOS:000257622200015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54586
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Baylor Coll Med, VA Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
3.Beijing HuiLongGuan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China
4.Anhui Med Univ, Coll Pharmacol, Hefei, Anhui, Peoples R China
5.Natl Inst Drug Dependence, Beijing, Peoples R China

Recommended Citation:
Zhang, Xiang Yang,Zhou, Dong Feng,Wu, Gui Ying,et al. BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia[J]. NEUROPSYCHOPHARMACOLOGY,2008,33(9):2200-2205.
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