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BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia
Zhang, Xiang Yang1,2,3; Zhou, Dong Feng2; Wu, Gui Ying3; Cao, Lian Yuan3; Tan, Yun Long3; Haile, Colin N.; Li, Jun4; Lu, Lin5; Kosten, Therese A.; Kosten, Thomas R.
关键词Schizophrenia Antipsychotic Weight Gain Bdnf Genotype Association
刊名NEUROPSYCHOPHARMACOLOGY
2008-08-01
DOI10.1038/sj.npp.1301619
33期:9页:2200-2205
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]NEUROTROPHIC FACTOR ; ATYPICAL ANTIPSYCHOTICS ; MELANOCORTIN-4 RECEPTOR ; GENE POLYMORPHISM ; ENERGY-BALANCE ; DIABETIC MICE ; RAT-BRAIN ; OBESITY ; PHARMACOGENETICS ; MANAGEMENT
英文摘要

Recent evidence suggests that centrally released brain-derived neurotrophic factor ( BDNF) modulates eating behavior and metabolism that is responsible for body weight fluctuation. BDNF also may play an important role in the therapeutic action of antipsychotic medications. We investigated whether the Val66Met polymorphism of the BDNF gene affected weight gain after long-term antipsychotic treatment in schizophrenia. The polymorphism was genotyped in 196 Chinese patients with schizophrenia on long-term antipsychotic medication. Serum BDNF was measured in all patients and 50 normal controls. Mean body mass index (BMI) change was evaluated retrospectively by means of clinical records. The results showed that there was a significant relationship between the three BDNF Val/Met genotypes and mean BMI gain, with genotype having a strong effect on BMI gain in male but not female patients. BDNF levels were significantly lower in patients than normal controls, and negatively correlated with BMI gain in female but not male patients. Our results suggest that variation in the BDNF gene may be a risk factor for weight gain in male patients with schizophrenia on long-term antipsychotic treatment, and decreased BDNF levels may be associated with weight gain in females.

语种英语
WOS记录号WOS:000257622200015
引用统计
被引频次:58[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54586
专题北京大学精神卫生研究所
作者单位1.Baylor Coll Med, VA Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
3.Beijing HuiLongGuan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China
4.Anhui Med Univ, Coll Pharmacol, Hefei, Anhui, Peoples R China
5.Natl Inst Drug Dependence, Beijing, Peoples R China
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GB/T 7714
Zhang, Xiang Yang,Zhou, Dong Feng,Wu, Gui Ying,et al. BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia[J]. NEUROPSYCHOPHARMACOLOGY,2008,33(9):2200-2205.
APA Zhang, Xiang Yang.,Zhou, Dong Feng.,Wu, Gui Ying.,Cao, Lian Yuan.,Tan, Yun Long.,...&Kosten, Thomas R..(2008).BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia.NEUROPSYCHOPHARMACOLOGY,33(9),2200-2205.
MLA Zhang, Xiang Yang,et al."BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia".NEUROPSYCHOPHARMACOLOGY 33.9(2008):2200-2205.
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