IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Cardiac Ankyrin Repeat Protein Attenuates Cardiac Hypertrophy by Inhibition of ERK1/2 and TGF-beta Signaling Pathways
Song, Yao3,4; Xu, Jialin1,2; Li, Yanfeng1,2; Jia, Chunshi1,2; Ma, Xiaowei3,4; Zhang, Lei1,2; Xie, Xiaojie6; Zhang, Yong1,2; Gao, Xiang5; Zhang, Youyi3,4; Zhu, Dahai1,2
刊名PLOS ONE
2012-12-05
DOI10.1371/journal.pone.0050436
7期:12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]LEFT-VENTRICULAR HYPERTROPHY ; PRESSURE-OVERLOAD ; DILATED CARDIOMYOPATHY ; REGULATED EXPRESSION ; INDUCED APOPTOSIS ; GENE-EXPRESSION ; HEART-FAILURE ; ANKRD1 ; CELLS ; TITIN
英文摘要

Aims: It has been reported that cardiac ankyrin repeat protein is associated with heart development and diseases. This study is aimed to investigate the role of CARP in heart hypertrophy in vivo.

Methods and Results: We generated a cardiac-specific CARP-overexpressing transgenic mouse. Although such animals did not display any overt physiological abnormality, they developed less cardiac hypertrophy in response to pressure overload than did wildtype mice, as indicated by heart weight/body weight ratios, echocardiographic and histological analyses, and expression of hypertrophic markers. These mice also exhibited less cardiac hypertrophy after infusion of isoproterenol. To gain a molecular insight into how CARP attenuated heart hypertrophy, we examined expression of the mitogen-activated protein kinase cascade and found that the concentrations of phosphorylated ERK1/2 and MEK were markedly reduced in the hearts of transgenic mice subjected to pressure overload. In addition, the expressions of TGF-beta and phosphorylated Smad3 were significantly downregulated in the hearts of CARP Tg mice in response to pressure overload. Furthermore, addition of human TGF-beta 1 could reverse the inhibitory effect of CARP on the hypertrophic response induced by phenylephrine in cardiomyocytes. It was also evidenced that the inhibitory effect of CARP on cardiac hypertrophy was not attributed to apoptosis.

Conclusion: CARP attenuates cardiac hypertrophy, in which the ERK and TGF-beta pathways may be involved. Our findings highlight the significance of CARP as an anti-hypertrophic factor in therapy of cardiac hypertrophy. Citation: Song Y, Xu J, Li Y, Jia C, Ma X, et al. (2012) Cardiac Ankyrin Repeat Protein Attenuates Cardiac Hypertrophy by Inhibition of ERK1/2 and TGF-b Signaling Pathways. PLoS ONE 7(12): e50436. doi:10.1371/journal.pone.0050436

语种英语
WOS记录号WOS:000312588200035
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54591
专题北京大学第三临床医学院
医学人文研究院/公共教学部_应用语言学系
北京大学第三临床医学院_心血管内科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
2.Chinese Acad Med Sci, Inst Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100730, Peoples R China
3.Peking Union Med Coll, Beijing 100021, Peoples R China
4.Peking Univ, Hosp 3, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Inst Vasc Med,Minist Hlth, Beijing 100871, Peoples R China
5.Nanjing Univ, Natl Resource Ctr Mutant Mice Model Anim Res, Nanjing, Jiangsu, Peoples R China
6.Zhejiang Univ, Coll Med, Affiliated Hosp 2, Dept Cardiol, Hangzhou 310003, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714
Song, Yao,Xu, Jialin,Li, Yanfeng,et al. Cardiac Ankyrin Repeat Protein Attenuates Cardiac Hypertrophy by Inhibition of ERK1/2 and TGF-beta Signaling Pathways[J]. PLOS ONE,2012,7(12).
APA Song, Yao.,Xu, Jialin.,Li, Yanfeng.,Jia, Chunshi.,Ma, Xiaowei.,...&Zhu, Dahai.(2012).Cardiac Ankyrin Repeat Protein Attenuates Cardiac Hypertrophy by Inhibition of ERK1/2 and TGF-beta Signaling Pathways.PLOS ONE,7(12).
MLA Song, Yao,et al."Cardiac Ankyrin Repeat Protein Attenuates Cardiac Hypertrophy by Inhibition of ERK1/2 and TGF-beta Signaling Pathways".PLOS ONE 7.12(2012).
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