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学科主题: 药学
题名:
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model
作者: Yang, Xiu-wei; Guo, Qing-mei; Wang, Ying; Xu, Wei; Tian, Li; Tian, Xiao-juan
关键词: Eucalyptus globulus ; macrocarpal A ; macrocarpal B ; cypellocarpa C ; intestinal permeability ; caco-2
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2007-02-15
DOI: 10.1016/j.bmcl.2006.11.021
卷: 17, 期:4, 页:1107-1111
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: ABSORPTION ; ACID
英文摘要:

The uptake and transepithelial transport of the three main constituents macrocarpal A (M-A), macrocarpal B (M-B), and cypellocarpa C (Cy-C) from the fruits of Eucalyptus globulus Labill. were investigated. Monolayers of the human intestinal epithelial cancer cell line Caco-2 were incubated with M-A, M-B, and Cy-C to model its intestinal absorption and transport, respectively. The determination of compounds was performed by HPLC. The apparent permeability coefficients (P-app) for M-A, M-B, and Cy-C in the apical-to-basolateral direction of a Caco-2 monolayer were (1.70 +/- 0.06) x 10(-6), (1.99 +/- 0.10) x 10(-6), and (6.08 +/- 0.41) x 10(-6) em/s, respectively. In the presence of iodoacetamide, the Papp of Cy-C were both reducted in apical-to-basolateral and basolateral-to-apical directions. M-A and M-B appear to accumulate in the epithelial cells. The intestinal absorption of M-A, M-B, and Cy-C was passive diffusion as the dominating process and Cy-C was partly ATP-dependent. (c) 2006 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000244636700049
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54597
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab & Biomimetr Drugs, Beijing 100083, Peoples R China
2.Shandong Univ Tradit Chinese Med, Jinan 250014, Peoples R China

Recommended Citation:
Yang, Xiu-wei,Guo, Qing-mei,Wang, Ying,et al. Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(4):1107-1111.
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