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Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model
Yang, Xiu-wei; Guo, Qing-mei; Wang, Ying; Xu, Wei; Tian, Li; Tian, Xiao-juan
关键词Eucalyptus Globulus Macrocarpal a Macrocarpal b Cypellocarpa c Intestinal Permeability Caco-2
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2007-02-15
DOI10.1016/j.bmcl.2006.11.021
17期:4页:1107-1111
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]ABSORPTION ; ACID
英文摘要

The uptake and transepithelial transport of the three main constituents macrocarpal A (M-A), macrocarpal B (M-B), and cypellocarpa C (Cy-C) from the fruits of Eucalyptus globulus Labill. were investigated. Monolayers of the human intestinal epithelial cancer cell line Caco-2 were incubated with M-A, M-B, and Cy-C to model its intestinal absorption and transport, respectively. The determination of compounds was performed by HPLC. The apparent permeability coefficients (P-app) for M-A, M-B, and Cy-C in the apical-to-basolateral direction of a Caco-2 monolayer were (1.70 +/- 0.06) x 10(-6), (1.99 +/- 0.10) x 10(-6), and (6.08 +/- 0.41) x 10(-6) em/s, respectively. In the presence of iodoacetamide, the Papp of Cy-C were both reducted in apical-to-basolateral and basolateral-to-apical directions. M-A and M-B appear to accumulate in the epithelial cells. The intestinal absorption of M-A, M-B, and Cy-C was passive diffusion as the dominating process and Cy-C was partly ATP-dependent. (c) 2006 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000244636700049
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54597
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab & Biomimetr Drugs, Beijing 100083, Peoples R China
2.Shandong Univ Tradit Chinese Med, Jinan 250014, Peoples R China
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Yang, Xiu-wei,Guo, Qing-mei,Wang, Ying,et al. Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(4):1107-1111.
APA Yang, Xiu-wei,Guo, Qing-mei,Wang, Ying,Xu, Wei,Tian, Li,&Tian, Xiao-juan.(2007).Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(4),1107-1111.
MLA Yang, Xiu-wei,et al."Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.4(2007):1107-1111.
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