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Time-Dependent Neuroendocrine Alterations and Drug Craving during the First Month of Abstinence in Heroin Addicts
Shi, Jie1; Li, Su-xia1; Zhang, Xiao-li1; Wang, Xi1; Le Foll, Bernard2; Zhang, Xiang-Yang3; Kosten, Thomas R.3; Lu, Lin1
关键词Acth Beta-endorphin Cortisol Drug Craving Heroin Abstainers Leptin Neuropeptide y
刊名AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
2009
DOI10.1080/00952990902933878
35期:5页:267-272
收录类别SSCI
文章类型Article
WOS标题词Social Sciences ; Science & Technology
类目[WOS]Psychology, Clinical ; Substance Abuse
研究领域[WOS]Psychology ; Substance Abuse
关键词[WOS]METHADONE-MAINTENANCE TREATMENT ; BETA-ENDORPHIN ; REWARD PATHWAYS ; CORTISOL-LEVELS ; NEUROPEPTIDE-Y ; WITHDRAWAL ; STRESS ; PLASMA ; NEUROBIOLOGY ; COCAINE
英文摘要

Rationale: Heroin use and withdrawal cause abnormality in the endocrine system. However, the time course of neuroendocrine alterations in heroin addicts during pharmacologically unassisted withdrawal is still unclear. Objectives: To investigate alterations in cortisol, adrenocorticotrophic hormone (ACTH), beta-endorphin (beta-EP), leptin, and neuropeptide Y (NPY) during the first month of abstinence in heroin addicts. Methods: Twelve heroin addicts and eight matched healthy control subjects were recruited for this study. The neuroendocrine alterations and self-reported heroin craving, anxiety, and depression in heroin addicts were assessed at different time points (days 3, 10, and 30) of first month of abstinence from heroin use. Results: Self-reported heroin craving, anxiety, and depression in heroin addicts decreased gradually during the first month of abstinence. The cortisol levels increased from abstinence day 3 to 30, while ACTH and beta-EP levels decreased over this period in heroin addicts. The leptin and NPY levels were significantly decreased on days 3 and 10 but had normalized on day 30 of abstinence. A positive correlation between cortisol level and heroin craving, anxiety, and depression was observed, while a negative correlation was observed between beta-EP level and craving and anxiety and between leptin and depression and NPY and anxiety. Conclusions: Abnormal alterations in the neuroendocrine system, including levels of cortisol, ACTH and beta-EP persist throughout the first month of abstinence. These results suggest that neuroendocrine system dysfunctions in heroin abusers is independent of the acute and protracted withdrawal syndromes, and may thus contribute to relapse to heroin use.

语种英语
WOS记录号WOS:000275031700001
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54600
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Univ Toronto, Ctr Addict & Mental Hlth, Translat Addict Res Lab, Toronto, ON, Canada
3.Baylor Coll Med, Div Alcohol & Addict Disorders, Houston, TX 77030 USA
推荐引用方式
GB/T 7714
Shi, Jie,Li, Su-xia,Zhang, Xiao-li,et al. Time-Dependent Neuroendocrine Alterations and Drug Craving during the First Month of Abstinence in Heroin Addicts[J]. AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,2009,35(5):267-272.
APA Shi, Jie.,Li, Su-xia.,Zhang, Xiao-li.,Wang, Xi.,Le Foll, Bernard.,...&Lu, Lin.(2009).Time-Dependent Neuroendocrine Alterations and Drug Craving during the First Month of Abstinence in Heroin Addicts.AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,35(5),267-272.
MLA Shi, Jie,et al."Time-Dependent Neuroendocrine Alterations and Drug Craving during the First Month of Abstinence in Heroin Addicts".AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE 35.5(2009):267-272.
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