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学科主题临床医学
microRNA-184 functions as tumor suppressor in renal cell carcinoma
Su, Zhengming1,2,3; Chen, Duqun1,3,4; Li, Yifan1,4; Zhang, Enpu1,3; Yu, Zuhu1,4; Chen, Ting1,2; Jiang, Zhimao1,3; Ni, Liangchao1,3; Yang, Shangqi1,3; Gui, Yaoting1,3; Ye, Jiongxian1,2,3; Lai, Yongqing1,2,3
关键词Renal Cell Carcinoma Microrna Mir-184
刊名EXPERIMENTAL AND THERAPEUTIC MEDICINE
2015-03-01
DOI10.3892/etm.2015.2199
9期:3页:961-966
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]BREAST-CANCER ; EXPRESSION ; PROFILES ; SURVIVAL ; GROWTH ; PROGNOSIS ; DIAGNOSIS
英文摘要

microRNAs (miRNAs) are evolutionarily conserved, endogenous, small, noncoding RNA molecules of approximately 22 nucleotides in length that function as post-transcriptional gene regulators. Their aberrant expression may be involved in human diseases, including cancer. Although miRNA-184 (miR-184) has been reported in other tumors, its function in renal cell carcinoma (RCC) is still unknown. The aim of the present study was to investigate the role of miR-184 in RCC. The impacts of miR-184 on cell migration, proliferation and apoptosis were evaluated using migration scratch, 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assay. Our studies revealed that miR-184 mimic significantly inhibits cell migration, suppresses cell proliferation and induces renal cancer cell apoptosis in vitro when compared with the negative control (P<0.05). In this study, it was observed that miR-184 played a significant role as a tumor suppressor in RCC. Therefore, miR-184 may be a promising therapeutic target for renal cancer treatment in the future.

语种英语
WOS记录号WOS:000350917900053
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54601
专题北京大学深圳医院
北京大学第一临床医学院_泌尿外科
作者单位1.Shantou Univ, Coll Med, Shantou 515041, Guangdong, Peoples R China
2.Anhui Med Univ, Hefei 230032, Anhui, Peoples R China
3.Peking Univ, Shanghai PKU HKUST Med Ctr, Shenzhen Hosp, Inst Urol,Dept Urol, Shenzhen 518036, Guangdong, Peoples R China
4.Peking Univ, Shanghai PKU HKUST Med Ctr, Shenzhen Hosp,Inst Urol, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen 518036, Guangdong, Peoples R China
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Su, Zhengming,Chen, Duqun,Li, Yifan,et al. microRNA-184 functions as tumor suppressor in renal cell carcinoma[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2015,9(3):961-966.
APA Su, Zhengming.,Chen, Duqun.,Li, Yifan.,Zhang, Enpu.,Yu, Zuhu.,...&Lai, Yongqing.(2015).microRNA-184 functions as tumor suppressor in renal cell carcinoma.EXPERIMENTAL AND THERAPEUTIC MEDICINE,9(3),961-966.
MLA Su, Zhengming,et al."microRNA-184 functions as tumor suppressor in renal cell carcinoma".EXPERIMENTAL AND THERAPEUTIC MEDICINE 9.3(2015):961-966.
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