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学科主题: 基础医学
题名:
Ganoderma total sterol (GS) and GS(1) protect rat cerebral cortical neurons from hypoxia/reoxygenation injury
作者: Zhao, HB; Wang, SZ; He, QH; Yuan, L; Chen, AF; Lin, ZB
关键词: ganoderma total sterol (GS) ; GS(1) ; cultured rat cortical neurons ; hypoxia/reoxygenation ; superoxide dismutase(SOD) ; nuclear factor-kappa B (NF-kappa B) ; cytokines
刊名: LIFE SCIENCES
发表日期: 2005-01-14
DOI: 10.1016/j.lfs.2004.08.013
卷: 76, 期:9, 页:1027-1037
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: NF-KAPPA-B ; ISCHEMIC BRAIN-DAMAGE ; TRANSCRIPTION FACTOR ; SUPEROXIDE DISMUTASES ; ACTIVATION ; ALPHA ; MESSENGERS ; MEDIATOR ; CELLS
英文摘要:

The effect of Ganoderma total sterol (GS) and its main components(GS(1)) on rat cortical neuronal cultures exposed to hypoxia/reoxygenation (H/R) was studied in vitro. GS (0.01,0.1,1 mug/ml) increased neuron viability following H/R. GS also significantly reduced malondialdehyde content and reactive oxygen species production and increased manganese superoxide dismutase (Mn-SOD) activity; furthermore, the translocation of nuclear factor-kappa B and the production of interleukin-1beta and tumor necrosis factor alpha induced by H/R. were also blocked. These findings suggest that GS might be useful in treating H/R-induced oxidative stress and inflammatory response. We also hypothesized that Mn-SOD might play a critical role in the neuroprotective effect of GS against H/R injury. In addition, pretreatment with GS(1) (0.01, 0.1, 1 mug/ml) significantly attenuated the decline of neuron viability and the formation of reactive oxygen species. Furthermore GS(1) possessed more potent protective effect on neurons compared with GS at the same dose. These findings demonstrated that GS(1) is the main component in GS; and play a critical role in the neuroprotective effect of GS against H/R. (C) 2004 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000226228000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54603
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Fuzhou Inst Green Valley Biopharm Technol, Fuzhou 350002, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Confocal Microscope Lab, Beijing 100083, Peoples R China
4.Michigan State Univ, Neurosci Program, E Lansing, MI 48824 USA
5.Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA
6.Michigan State Univ, Dept Neurol & Ophthalmol, E Lansing, MI 48824 USA

Recommended Citation:
Zhao, HB,Wang, SZ,He, QH,et al. Ganoderma total sterol (GS) and GS(1) protect rat cerebral cortical neurons from hypoxia/reoxygenation injury[J]. LIFE SCIENCES,2005,76(9):1027-1037.
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