IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学肝病研究所
学科主题临床医学
Molecular epidemiology and evolution of influenza A and B viruses during winter 2013-2014 in Beijing, China
Fang, Qiongxuan; Gao, Yan; Chen, Meifang; Guo, Xiaolin; Yang, Xia; Wei, Lai
刊名ARCHIVES OF VIROLOGY
2015-04-01
DOI10.1007/s00705-015-2362-x
160期:4页:1083-1095
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
资助者Peking University People&prime ; s Hospital ; Peking University People&prime ; s Hospital
研究领域[WOS]Virology
关键词[WOS]HEMAGGLUTININ GENE ; NEURAMINIDASE ; LINEAGES ; TAIWAN ; COCIRCULATION ; CIRCULATION ; EMERGENCE ; SEQUENCE ; DELETION ; STRAINS
英文摘要

In this study, we investigated the molecular epidemiology and evolution of influenza viruses from patients infected during the 2013-2014 influenza season in Beijing. A phylogenetic analysis of the hemagglutinin (HA) and neuraminidase (NA) sequences of influenza A and B viruses from 18 patients (6 A(H1N1)pdm09, 4 H3N2, and 8 influenza B virus) was performed. Among the influenza A viruses, A(H1N1) pdm09 was the dominant subtype, whereas the B/Yamagata lineage was predominant for influenza B. The influenza B HA and NA strains in Beijing were dominated by reassortants derived from the Yamagata lineage and the Victoria lineage, respectively. All six A(H1N1) pdm09 strains fell into the 6B genetic group with amino acid substitutions D97N, S185T, K163Q, and A256T; the four H3N2 strains fell into genetic group 3C. 3 with substitutions T128A, R142G, N145S, and V186G, and the eight influenza B strains were categorized into subgroup 3.1 and harbored an N217S mutation. Two new mutations (K180Q and G187E at the Sa and Ca antigenic sites of the H1 segment, respectively), which were not detected during the preceding influenza season, were identified. Mutations N131K, S165I, N181Y, and D212N in HA of influenza B mapped to the 120-loop, 150-loop, 160-loop, and 190-helix, respectively. Our results reveal the molecular epidemiology and phylogenetic characteristics of influenza viruses within a single geographic location and can have implications for vaccination selection in northern China.

语种英语
所属项目编号RDC2014-06 ; 2118000586
资助者Peking University People&prime ; s Hospital ; Peking University People&prime ; s Hospital
WOS记录号WOS:000351514100021
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54605
Collection北京大学第二临床医学院_北京大学肝病研究所
作者单位Peking Univ, Peoples Hosp, Inst Hepatol, Dept Infect Dis, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Fang, Qiongxuan,Gao, Yan,Chen, Meifang,et al. Molecular epidemiology and evolution of influenza A and B viruses during winter 2013-2014 in Beijing, China[J]. ARCHIVES OF VIROLOGY,2015,160(4):1083-1095.
APA Fang, Qiongxuan,Gao, Yan,Chen, Meifang,Guo, Xiaolin,Yang, Xia,&Wei, Lai.(2015).Molecular epidemiology and evolution of influenza A and B viruses during winter 2013-2014 in Beijing, China.ARCHIVES OF VIROLOGY,160(4),1083-1095.
MLA Fang, Qiongxuan,et al."Molecular epidemiology and evolution of influenza A and B viruses during winter 2013-2014 in Beijing, China".ARCHIVES OF VIROLOGY 160.4(2015):1083-1095.
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