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学科主题临床医学
Etiology and Clinical Characteristics of Influenza-Like Illness (ILI) in Outpatients in Beijing, June 2010 to May 2011
Yang, XiaoHua1; Yao, Yao2; Chen, MeiFang1; Yang, Xia1; Xie, YanDi1; Liu, YaFen1; Zhao, XiuYing2; Gao, Yan1; Wei, Lai1
刊名PLOS ONE
2012-01-04
DOI10.1371/journal.pone.0028786
7期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]RESPIRATORY SYNCYTIAL VIRUS ; CASE-DEFINITION ; CHILDREN ; INFECTIONS ; DIAGNOSIS ; SURVEILLANCE ; EPIDEMICS ; SEASON ; IMPACT
英文摘要

Background: Since May 2009, exposure of the population of Beijing, China to pH1N1 has resulted in an increase in respiratory illnesses. Limited information is available on the etiology and clinical characteristics of the influenza-like illness (ILI) that ensued in adults following the pH1N1 pandemic.

Methods: Clinical and epidemiological data of ILI in adults was collected. A total of 279 throat swabs were tested for twelve respiratory viruses using multiplex RT-PCR. Clinical characteristics of influenza A in outpatients versus test-negative patients were compared using Pearson′s chi(2) and the Mann-Whitney U test. 190 swabs were tested for pH1N1 by virus isolation. Consultation rates for ILI were compared between 2009 and 2010.

Results: One or two virus were detected in 29% of the samples. Influenza A virus (FLU-A) accounted for 22.9% (64/279). Other viruses were present at a frequency less than 3.0%. Cough was significantly associated with Influenza A virus infection (chi(2), p<0.001). The positive rate of FLU-A was consistent with changes in the ILI rate during the same period and there was a significant reduction in the incidence of ILI in 2010 when compared to 2009. During the 2010-2011 influenza season, the incidence peaked in January 2011 in Beijing and north China.

Conclusions: Exposure to pH1N1 had no impact on typical influenza seasonal peaks, although FLU-A remained the predominant virus for 2010 in Beijing. Symptomatically, cough was associated with FLU-A infection. The positive rate of influenza virus was consistent with changes in the ILI rate during the same period and there was a significant reduction in the incidence of ILI in 2010 when compared to that of 2009.

语种英语
WOS记录号WOS:000301070200011
项目编号2009ZX10004-110
资助机构National Science and Technology Major Special Funding, People&prime ; s Republic of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54608
专题北京大学第二临床医学院_感染科
北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Peking Univ, Peoples Hosp, Inst Hepatol, Dept Infect Dis, Beijing 100871, Peoples R China
2.Capital Med Univ, Beijing YouAn Hosp, Ctr Clin Lab, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Yang, XiaoHua,Yao, Yao,Chen, MeiFang,et al. Etiology and Clinical Characteristics of Influenza-Like Illness (ILI) in Outpatients in Beijing, June 2010 to May 2011[J]. PLOS ONE,2012,7(1).
APA Yang, XiaoHua.,Yao, Yao.,Chen, MeiFang.,Yang, Xia.,Xie, YanDi.,...&Wei, Lai.(2012).Etiology and Clinical Characteristics of Influenza-Like Illness (ILI) in Outpatients in Beijing, June 2010 to May 2011.PLOS ONE,7(1).
MLA Yang, XiaoHua,et al."Etiology and Clinical Characteristics of Influenza-Like Illness (ILI) in Outpatients in Beijing, June 2010 to May 2011".PLOS ONE 7.1(2012).
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