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学科主题: 临床医学
题名:
Etiology and Clinical Characteristics of Influenza-Like Illness (ILI) in Outpatients in Beijing, June 2010 to May 2011
作者: Yang, XiaoHua1; Yao, Yao2; Chen, MeiFang1; Yang, Xia1; Xie, YanDi1; Liu, YaFen1; Zhao, XiuYing2; Gao, Yan1; Wei, Lai1
刊名: PLOS ONE
发表日期: 2012-01-04
DOI: 10.1371/journal.pone.0028786
卷: 7, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: RESPIRATORY SYNCYTIAL VIRUS ; CASE-DEFINITION ; CHILDREN ; INFECTIONS ; DIAGNOSIS ; SURVEILLANCE ; EPIDEMICS ; SEASON ; IMPACT
英文摘要:

Background: Since May 2009, exposure of the population of Beijing, China to pH1N1 has resulted in an increase in respiratory illnesses. Limited information is available on the etiology and clinical characteristics of the influenza-like illness (ILI) that ensued in adults following the pH1N1 pandemic.

Methods: Clinical and epidemiological data of ILI in adults was collected. A total of 279 throat swabs were tested for twelve respiratory viruses using multiplex RT-PCR. Clinical characteristics of influenza A in outpatients versus test-negative patients were compared using Pearson′s chi(2) and the Mann-Whitney U test. 190 swabs were tested for pH1N1 by virus isolation. Consultation rates for ILI were compared between 2009 and 2010.

Results: One or two virus were detected in 29% of the samples. Influenza A virus (FLU-A) accounted for 22.9% (64/279). Other viruses were present at a frequency less than 3.0%. Cough was significantly associated with Influenza A virus infection (chi(2), p<0.001). The positive rate of FLU-A was consistent with changes in the ILI rate during the same period and there was a significant reduction in the incidence of ILI in 2010 when compared to 2009. During the 2010-2011 influenza season, the incidence peaked in January 2011 in Beijing and north China.

Conclusions: Exposure to pH1N1 had no impact on typical influenza seasonal peaks, although FLU-A remained the predominant virus for 2010 in Beijing. Symptomatically, cough was associated with FLU-A infection. The positive rate of influenza virus was consistent with changes in the ILI rate during the same period and there was a significant reduction in the incidence of ILI in 2010 when compared to that of 2009.

语种: 英语
所属项目编号: 2009ZX10004-110
项目资助者: National Science and Technology Major Special Funding, People&prime ; s Republic of China
WOS记录号: WOS:000301070200011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54608
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Inst Hepatol, Dept Infect Dis, Beijing 100871, Peoples R China
2.Capital Med Univ, Beijing YouAn Hosp, Ctr Clin Lab, Beijing, Peoples R China

Recommended Citation:
Yang, XiaoHua,Yao, Yao,Chen, MeiFang,et al. Etiology and Clinical Characteristics of Influenza-Like Illness (ILI) in Outpatients in Beijing, June 2010 to May 2011[J]. PLOS ONE,2012,7(1).
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