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学科主题: 临床医学
题名:
Effects of biological variations on platelet count in healthy subjects in China
作者: Peng, LM; Yang, J; Lu, XJ; Okada, T; Kondo, T; Ruan, CG; Wu, Y; Xin, XM
关键词: platelet count ; healthy adults ; biological variation ; China
刊名: THROMBOSIS AND HAEMOSTASIS
发表日期: 2004-02-01
DOI: 10.1160/TH03-05-0276
卷: 91, 期:2, 页:367-372
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: REFERENCE INTERVALS ; FISH OIL ; DISEASE
英文摘要:

The effects of biological variations on platelet counts were investigated in 694 healthy subjects aged 18 to 60 years living in three cities including Chengdu (Sichuan Province), Suzhou (Jiangsu Province) and Harbin (Heilongjang Province) in China. Platelet counts in healthy subjects were significantly lower in Chengdu (52similar to202 X 10(9)/L) and Suzhou (60similar to259 X 10(9)/L) than in Harbin (154similar to348 X 10(9)/L)(p <0.0001), but the mean platelet volume (MPV) determined concurrently was negatively correlated with platelet count, the MPV values were significantly higher in Chengdu (11.8&SIM;15.6 fl) and Suzhou (10.9&SIM;15.8 fl) than in Harbin (9.5&SIM;12.9 fl) (p < 0.0001). Platelet counts were significantly higher in summer (73similar to289 X 10(9)/L) than in winter (52similar to202 X 10(9)/L) (p <0.0001), but the MPV values were lower in summer (11.2&SIM;14.7 fl) than in winter (11.8&SIM;15.6 fl) (p <0.05) in Chengdu. Platelet associated immunoglobulin (PA-IgG) in Chengdu was revealed to be significantly higher in the low platelet count group (< 150 X 10(9)/L, 13.5 +/- 7.1 ng/10(7) PLT) than in the normal platelet count group (&GE; 150 X 10(9)/L, 8.3 +/- 2.7 ng/10(7) PLT)(p <0.0001). Similar results were observed in Suzhou for the reticulated platelet ratio, which was significantly higher in the low platelet count group (19.5 +/- 7.1%) than in the normal platelet count group (11.6 +/- 2.7%)(p <0.01). The bleeding time in Chengdu showed a significantly longer time in the low platelet count group (8.6 +/- 2.3 min) than in the normal platelet count group (6.0 +/- 1.2 min)(p <0.01). With regard to the effects of lipids on platelet counts, the HDL values were significantly higher in the normal platelet count group (1.60 +/- 0.76 mmol/L) than the low platelet count group (1.23 +/- 0.31 mmol/L) (p <0.01); but no significant differences in cholesterol and triglycerides values between the normal and low platelet count groups (p >0.05) were recorded. These findings suggest that the platelet counts could be greatly influenced in healthy subjects by biological variations such as geographical, seasonal, and lipid variations.

语种: 英语
WOS记录号: WOS:000189118700022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/54612
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Sichuan Univ, W China Hosp, Sichuan, Peoples R China
2.Harbin Med Coll, Hosp 1, Harbin, Peoples R China
3.Suzhou Univ, Med Coll Hosp 1, Suzhou, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Lab Med, Shenzhen 518036, Peoples R China

Recommended Citation:
Peng, LM,Yang, J,Lu, XJ,et al. Effects of biological variations on platelet count in healthy subjects in China[J]. THROMBOSIS AND HAEMOSTASIS,2004,91(2):367-372.
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