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学科主题临床医学
Effects of biological variations on platelet count in healthy subjects in China
Peng, LM; Yang, J; Lu, XJ; Okada, T; Kondo, T; Ruan, CG; Wu, Y; Xin, XM
关键词Platelet Count Healthy Adults Biological Variation China
刊名THROMBOSIS AND HAEMOSTASIS
2004-02-01
DOI10.1160/TH03-05-0276
91期:2页:367-372
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]REFERENCE INTERVALS ; FISH OIL ; DISEASE
英文摘要

The effects of biological variations on platelet counts were investigated in 694 healthy subjects aged 18 to 60 years living in three cities including Chengdu (Sichuan Province), Suzhou (Jiangsu Province) and Harbin (Heilongjang Province) in China. Platelet counts in healthy subjects were significantly lower in Chengdu (52similar to202 X 10(9)/L) and Suzhou (60similar to259 X 10(9)/L) than in Harbin (154similar to348 X 10(9)/L)(p <0.0001), but the mean platelet volume (MPV) determined concurrently was negatively correlated with platelet count, the MPV values were significantly higher in Chengdu (11.8&SIM;15.6 fl) and Suzhou (10.9&SIM;15.8 fl) than in Harbin (9.5&SIM;12.9 fl) (p < 0.0001). Platelet counts were significantly higher in summer (73similar to289 X 10(9)/L) than in winter (52similar to202 X 10(9)/L) (p <0.0001), but the MPV values were lower in summer (11.2&SIM;14.7 fl) than in winter (11.8&SIM;15.6 fl) (p <0.05) in Chengdu. Platelet associated immunoglobulin (PA-IgG) in Chengdu was revealed to be significantly higher in the low platelet count group (< 150 X 10(9)/L, 13.5 +/- 7.1 ng/10(7) PLT) than in the normal platelet count group (&GE; 150 X 10(9)/L, 8.3 +/- 2.7 ng/10(7) PLT)(p <0.0001). Similar results were observed in Suzhou for the reticulated platelet ratio, which was significantly higher in the low platelet count group (19.5 +/- 7.1%) than in the normal platelet count group (11.6 +/- 2.7%)(p <0.01). The bleeding time in Chengdu showed a significantly longer time in the low platelet count group (8.6 +/- 2.3 min) than in the normal platelet count group (6.0 +/- 1.2 min)(p <0.01). With regard to the effects of lipids on platelet counts, the HDL values were significantly higher in the normal platelet count group (1.60 +/- 0.76 mmol/L) than the low platelet count group (1.23 +/- 0.31 mmol/L) (p <0.01); but no significant differences in cholesterol and triglycerides values between the normal and low platelet count groups (p >0.05) were recorded. These findings suggest that the platelet counts could be greatly influenced in healthy subjects by biological variations such as geographical, seasonal, and lipid variations.

语种英语
WOS记录号WOS:000189118700022
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/54612
专题北京大学深圳医院
作者单位1.Sichuan Univ, W China Hosp, Sichuan, Peoples R China
2.Harbin Med Coll, Hosp 1, Harbin, Peoples R China
3.Suzhou Univ, Med Coll Hosp 1, Suzhou, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Lab Med, Shenzhen 518036, Peoples R China
推荐引用方式
GB/T 7714
Peng, LM,Yang, J,Lu, XJ,et al. Effects of biological variations on platelet count in healthy subjects in China[J]. THROMBOSIS AND HAEMOSTASIS,2004,91(2):367-372.
APA Peng, LM.,Yang, J.,Lu, XJ.,Okada, T.,Kondo, T.,...&Xin, XM.(2004).Effects of biological variations on platelet count in healthy subjects in China.THROMBOSIS AND HAEMOSTASIS,91(2),367-372.
MLA Peng, LM,et al."Effects of biological variations on platelet count in healthy subjects in China".THROMBOSIS AND HAEMOSTASIS 91.2(2004):367-372.
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